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This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] See more...
Aliases for HES1 Gene
Aliases for HES1 Gene
External Ids for HES1 Gene
- HGNC: 5192
- NCBI Entrez Gene: 3280
- Ensembl: ENSG00000114315
- OMIM®: 139605
- UniProtKB/Swiss-Prot: Q14469
Previous HGNC Symbols for HES1 Gene
- HRY
Previous GeneCards Identifiers for HES1 Gene
- GC03P195130
- GC03P195255
- GC03P195174
- GC03P195336
- GC03P193853
- GC03P191241
Summaries for HES1 Gene
-
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
GeneCards Summary for HES1 Gene
HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Medulloblastoma and T-Cell Lymphoblastic Leukemia/Lymphoma. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Notch-mediated HES/HEY network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HES4.
UniProtKB/Swiss-Prot Summary for HES1 Gene
-
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Additional gene information for HES1 Gene
- HGNC (5192)
- NCBI Entrez Gene (3280)
- Ensembl (ENSG00000114315)
- OMIM® (139605)
- UniProtKB/Swiss-Prot (Q14469)
- Open Targets Platform(ENSG00000114315)
- Monarch Initiative
- Search for HES1 at DataMed
- Search for HES1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HES1 Gene
Genomics for HES1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HES1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HES1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HES1
- Top Transcription factor binding sites by QIAGEN in the HES1 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- GATA-1
- STAT3
Genomic Locations for HES1 Gene
Latest Assembly
- chr3:194,136,148-194,138,732
- (GRCh38/hg38)
- Size:
- 2,585 bases
- Orientation:
- Plus strand
Previous Assembly
- chr3:193,853,937-193,856,521
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,585 bases
- Orientation:
- Plus strand
- chr3:193,853,934-193,856,521
- (GRCh37/hg19 by Ensembl)
- Size:
- 2,588 bases
- Orientation:
- Plus strand
Genomic View for HES1 Gene
Genes around HES1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q29 by HGNC
- 3q29 by Entrez Gene
- 3q29 by Ensembl
HES1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HES1 Gene
Proteins for HES1 Gene
-
Protein details for HES1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14469-HES1_HUMAN
- Recommended name:
- Transcription factor HES-1
- Protein Accession:
- Q14469
- Q6FHB2
Protein attributes for HES1 Gene
- Size:
- 280 amino acids
- Molecular mass:
- 29541 Da
- Quaternary structure:
-
- Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
Protein Expression for HES1 Gene
Post-translational modifications for HES1 Gene
Other Protein References for HES1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences HES1 / HES-1 Antibody (LS-B2211) and HES1 / HES-1 Antibody (LS-B6364)
- G Biosciences Immunotagā¢ Hes1 Antibody
- NSJ Bioreagents HES1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for HES1
- AM10222PU-N
- AP13263PU-N
- AP31766PU-N
- AP55327PU-N
- CF500114
- CF503958
- CF504001
- CF504002
- CF504045
- CF504046
- CF504067
- CF504088
- TA336954
- TA400011
- TA400012
- TA400013
- TA500114
- TA500114S
- TA503958
- TA503958S
- TA504001
- TA504001S
- TA504002
- TA504002S
- TA504045
- TA504045S
- TA504046
- TA504046S
- TA504067
- TA504067S
- TA504088
- TA504088S
- TA600482
- TA600483
- TA600484
- TA600485
- TA700482
- TA700483
- TA700484
- Novus Biologicals Antibodies for HES1
-
Abcam antibodies for HES1
- Invitrogen Antibodies for HES1 (AFLGC-HES1)
-
Biorbyt antibodies for HES1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HES1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for HES1
- Origene Custom Protein Services for HES1
-
ProSci Proteins for HES1
-
Abcam proteins for HES1
Assay products for research
- antibodies-online: Show 15 available HES1 Elisa Kits ranked by validation data
- Compare Top HES1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for HES1 Gene
Domains & Families for HES1 Gene
Gene Families for HES1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HES1 Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- Orange
- ProtoNet:
Suggested Antigen Peptide Sequences for HES1 Gene
- GenScript: Design optimal peptide antigens:
-
- Hairy-like protein (HES1_HUMAN)
- HES1 protein (Q8IXV0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14469UniProtKB/Swiss-Prot:
HES1_HUMAN :- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- Domain:
-
- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
- The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
Function for HES1 Gene
Molecular function for HES1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Phenotypes From GWAS Catalog for HES1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
| GO:0001085 | RNA polymerase II transcription factor binding | IEA,ISS | -- |
| GO:0001217 | bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding | IEA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
Phenotypes for HES1 Gene
- MGI mutant phenotypes for HES1:
-
inferred from 7 alleles
- normal phenotype
- nervous system phenotype
- growth/size/body region phenotype
- cellular phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for HES1:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HES1 - Starting at $85 >
- * HES1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HES1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HES1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
miRNA for HES1 Gene
- miRTarBase miRNAs that target HES1
-
- hsa-miR-199b-5p (MIRT000208)
- mmu-miR-23b-3p (MIRT002493)
- hsa-miR-23a-3p (MIRT002953)
- mmu-miR-9-5p (MIRT005793)
- xtr-miR-9-5p (MIRT006009)
- hsa-miR-524-5p (MIRT006893)
- mmu-miR-7b-5p (MIRT009157)
- hsa-miR-296-3p (MIRT038426)
- hsa-miR-222-3p (MIRT046625)
- hsa-miR-92a-3p (MIRT049494)
- hsa-let-7b-5p (MIRT051991)
- mmu-miR-1a-3p (MIRT054185)
- mmu-miR-146a-5p (MIRT732708)
- hsa-miR-410-3p (MIRT732784)
- hsa-miR-9-3p (MIRT734264)
- hsa-miR-9-5p (MIRT734265)
- hsa-miR-381-5p (MIRT734876)
- hsa-miR-765 (MIRT735477)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HES1
Clone products for research
- Applied Biological Materials (abm): Clones for HES1 - Starting at $45 >
- * HES1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HES1
- Addgene plasmids for HES1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HES1
Cell Lines for research
-
Horizon Cell Lines for HES1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HES1 Gene
Localization for HES1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HES1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
Pathways & Interactions for HES1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | Regulation of beta-cell development | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
Pathways by source for HES1 Gene
1 Sino Biological pathway for HES1 Gene
11 BioSystems pathways for HES1 Gene
16 Reactome pathways for HES1 Gene
7 KEGG pathways for HES1 Gene
1 GeneGo (Thomson Reuters) pathway for HES1 Gene
- Development Notch Signaling Pathway
2 R&D Systems pathways for HES1 Gene
1 Cell Signaling Technology pathway for HES1 Gene
Interacting Proteins for HES1 Gene
Selected Interacting proteins:
Q14469-HES1_HUMAN
ENSP00000232424
for HES1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HES1
SIGNOR curated interactions for HES1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 12032823 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0003143 | embryonic heart tube morphogenesis | IEA,ISS | -- |
| GO:0003151 | outflow tract morphogenesis | IEA,ISS | -- |
Transcripts for HES1 Gene
mRNA/cDNA for HES1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000232424 1575 nts (view in UCSC)
- ENST00000476918 1009 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HES1 - Starting at $85 >
- * HES1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HES1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HES1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HES1
Clone products for research
- Applied Biological Materials (abm): Clones for HES1 - Starting at $45 >
- * HES1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HES1
- Addgene plasmids for HES1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HES1
Relevant External Links for HES1 Gene
- GeneLoc Exon Structure for
- HES1
Expression for HES1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Fetal Matrix Cells Hair Follicle
- Anterior Lens Epithelial Cells Lens
- Fetal Inner Root Sheath Cells Inner Root Sheath
-
Pancreas (Endocrine System)
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Duct Progenitor Cells Dorsal Pancreatic Bud
- Centroacinar Cells Pancreatic Ducts
- Duct Progenitor Cells Ventral Pancreatic Bud
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
-
Eye (Sensory Organs)
- Anterior Lens Epithelial Cells Lens
- Equatorial Lens Epithelial Cells Lens
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Neural Tube (Nervous System)
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Tooth (Integumentary System)
- Primary Enamel Knot Cells Enamel Knot
- Stellate Reticulum Cells Dental Core
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Cerebellum
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
-
Ectoderm (Gastrulation Derivatives)
- Preplacodal Ectoderm Cells Preplacodal Ectoderm
-
Lung (Respiratory System)
- Bronchiolar Progenitor Cells Stem Bronchi
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Epidermis (Integumentary System)
- Granular Keratinocytes Stratified Epidermis
- Gut Tube (Gastrointestinal Tract)
- Blood (Hematopoietic System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HES1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.4).
This gene is overexpressed in Blymphocyte (52.9) and Heart (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HES1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HES1
SOURCE GeneReport for Unigene cluster for HES1 Gene:
Hs.250666Evidence on tissue expression from TISSUES for HES1 Gene
- Liver(4.9)
- Kidney(4.5)
- Muscle(2.9)
- Nervous system(2.8)
- Eye(2.7)
- Skin(2.4)
- Intestine(2.4)
- Lung(2.2)
- Heart(2.2)
- Pancreas(2.1)
- Thyroid gland(2.1)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for HES1
-
OriGene qPCR primer pairs and template standards for HES1
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES1 Gene
Orthologs for HES1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HES1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HES1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hes1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hes1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HES1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HES1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CHAIRY-1 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hes1 30 |
|
||
| Str.10866 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397813 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | her6 30 |
|
||
| her9 31 |
|
ManyToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.686 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | h 31 |
|
ManyToMany | |
| dpn 31 |
|
ManyToMany | |||
| Side 31 |
|
ManyToMany |
- Species where no ortholog for HES1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HES1 Gene
- ENSEMBL:
- Gene Tree for HES1 (if available)
- TreeFam:
- Gene Tree for HES1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HES1: view image
Paralogs for HES1 Gene
Variants for HES1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HES1 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs141702996 | Likely Benign: not provided | 194,138,167(+) |
C/T NM_005524.4(HES1):c.777C>T (p.Asn259=) |
SYNONYMOUS | |
| rs148500265 | Benign: not provided | 194,137,678(+) |
C/T NM_005524.4(HES1):c.293-5C>T |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HES1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HES1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES1 Gene
Disorders for HES1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| medulloblastoma |
|
|
| t-cell lymphoblastic leukemia/lymphoma |
|
|
| breast cancer |
|
|
| maturity-onset diabetes of the young |
|
|
| 3-methylglutaconic aciduria, type iii |
|
|
Search HES1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HES1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HES1 Gene
Publications for HES1 Gene
- HES1 is a novel interactor of the Fanconi anemia core complex. (PMID: 18550849) Tremblay CS ā¦ Carreau M (Blood 2008) 3 4 23
- Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. (PMID: 12535671) Takata T ā¦ Ishikawa F (Biochemical and biophysical research communications 2003) 3 4 23
- Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. (PMID: 8020957) Feder JN ā¦ Jan YN (Genomics 1994) 2 3 4
- Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (PMID: 19861684) Nakahara F ā¦ Chiba S (Blood 2010) 3 23
- Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. (PMID: 20022559) Sang L ā¦ Coller HA (Trends in molecular medicine 2010) 3 23
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Sources for HES1 Gene
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