Aliases for HES1 Gene
Aliases for HES1 Gene
External Ids for HES1 Gene
- HGNC: 5192
- Entrez Gene: 3280
- Ensembl: ENSG00000114315
- OMIM: 139605
- UniProtKB: Q14469
Previous HGNC Symbols for HES1 Gene
- HRY
Previous GeneCards Identifiers for HES1 Gene
- GC03P195130
- GC03P195255
- GC03P195174
- GC03P195336
- GC03P193853
- GC03P191241
Summaries for HES1 Gene
-
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
GeneCards Summary for HES1 Gene
HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Medulloblastoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Signaling by NOTCH1 and Regulation of beta-cell development. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HES4.
UniProtKB/Swiss-Prot for HES1 Gene
-
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Additional gene information for HES1 Gene
- Monarch Initiative
- Search for HES1 at DataMed
- Search for HES1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES1 Gene
Genomics for HES1 Gene
GeneHancer (GH) Regulatory Elements for HES1 Gene
Promoters and enhancers for HES1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HES1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HES1 Gene
Genomic Locations for HES1 Gene
- chr3:194,136,142-194,138,732
- (GRCh38/hg38)
- Size:
- 2,591 bases
- Orientation:
- Plus strand
- chr3:193,853,931-193,856,521
- (GRCh37/hg19)
Genomic View for HES1 Gene
Genes around HES1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q29 by Ensembl
- 3q29 by Entrez Gene
- 3q29 by HGNC
HES1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HES1 Gene
Proteins for HES1 Gene
-
Protein details for HES1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14469-HES1_HUMAN
- Recommended name:
- Transcription factor HES-1
- Protein Accession:
- Q14469
- Q6FHB2
Protein attributes for HES1 Gene
- Size:
- 280 amino acids
- Molecular mass:
- 29541 Da
- Quaternary structure:
-
- Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
Protein Expression for HES1 Gene
Post-translational modifications for HES1 Gene
Other Protein References for HES1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HES1 (HES-1)
-
Custom Antibody ServicesOriGene Antibodies for HES1
- Novus Biologicals Antibodies for HES1
-
Abcam antibodies for HES1
-
Cloud-Clone Corp. Antibodies for HES1
- Invitrogen Antibodies for HES1
- antibodies-online: Search results for available HES1 related products ranked by validation data
- GeneTex HES1 antibody for HES1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HES1
Protein Products
-
OriGene Purified Proteins for HES1
- Search Origene for MassSpec and Protein Over-expression Lysates for HES1
- Origene Custom Protein Services for HES1
-
Cloud-Clone Corp. Proteins for HES1
- antibodies-online: Search results for available HES1 related products ranked by validation data
- Search GeneTex for Proteins for HES1
-
ProSci Proteins for HES1
-
Abcam proteins for HES1
Assay Products
- antibodies-online: Search results for available HES1 related products ranked by validation data
No data available for DME Specific Peptides for HES1 Gene
Domains & Families for HES1 Gene
Gene Families for HES1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HES1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HES1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14469UniProtKB/Swiss-Prot:
HES1_HUMAN :- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- Domain:
-
- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
- The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
Function for HES1 Gene
Molecular function for HES1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Phenotypes From GWAS Catalog for HES1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ISS,IEA | -- |
| GO:0003677 | DNA binding | TAS | 7906273 |
| GO:0003700 | DNA binding transcription factor activity | IDA | 17681138 |
| GO:0005515 | protein binding | IPI | 12535671 |
Phenotypes for HES1 Gene
- MGI mutant phenotypes for HES1:
-
inferred from 7 alleles
- nervous system phenotype
- normal phenotype
- respiratory system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for HES1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HES1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
- Search ViGene Biosciences for HES1
CRISPR Products
-
OriGene CRISPR knockouts for HES1
- genomics-online: gRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- Applied Biological Materials CRISPR for HES1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- GenScript: Design CRISPR guide RNA sequences for HES1
miRNA for HES1 Gene
- miRTarBase miRNAs that target HES1
-
- hsa-mir-199b-5p (MIRT000208)
- hsa-mir-23a-3p (MIRT002953)
- hsa-mir-524-5p (MIRT006893)
- hsa-mir-296-3p (MIRT038426)
- hsa-mir-222-3p (MIRT046625)
- hsa-mir-92a-3p (MIRT049494)
- hsa-let-7b-5p (MIRT051991)
- hsa-mir-410-3p (MIRT732784)
- hsa-mir-9-3p (MIRT734264)
- hsa-mir-9-5p (MIRT734265)
- hsa-mir-381-5p (MIRT734876)
- hsa-mir-765 (MIRT735477)
miRNA Products
- Search ViGene Biosciences for HES1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
- genomics-online: shRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
Clone Products
- Sino Biological Human cDNA Clone for HES1
- VectorBuilder custom plasmid, inducible vectors for HES1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HES1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HES1
- Applied Biological Materials Clones for HES1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HES1
-
ViGene Biosciences adenoviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HES1 Gene
Localization for HES1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HES1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for HES1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch signaling pathway (KEGG) | ||
| 3 | Regulation of beta-cell development | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
Pathways by source for HES1 Gene
11 BioSystems pathways for HES1 Gene
16 Reactome pathways for HES1 Gene
6 KEGG pathways for HES1 Gene
1 GeneGo (Thomson Reuters) pathway for HES1 Gene
2 R&D Systems pathways for HES1 Gene
1 Cell Signaling Technology pathway for HES1 Gene
Interacting Proteins for HES1 Gene
Selected Interacting proteins:
ENSP00000232424
Q14469-HES1_HUMAN
for HES1 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for HES1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 12032823 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0003143 | embryonic heart tube morphogenesis | IEA,ISS | -- |
| GO:0003151 | outflow tract morphogenesis | ISS,IEA | -- |
Transcripts for HES1 Gene
mRNA/cDNA for HES1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (213) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HES1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HES1
- genomics-online: gRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- Applied Biological Materials CRISPR for HES1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- GenScript: Design CRISPR guide RNA sequences for HES1
miRNA Products
- Search ViGene Biosciences for HES1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
- genomics-online: shRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
Clone Products
- Sino Biological Human cDNA Clone for HES1
- VectorBuilder custom plasmid, inducible vectors for HES1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HES1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HES1
- Applied Biological Materials Clones for HES1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HES1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells (Uncategorized)
- Tubular cell-enriched subpopulation of renal cells
- Human fetal pancreatic progenitor cells
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
- Duct Cells Pancreatic Ducts
- Acinar Cells Pancreatic Acini
- Pancreas (Endocrine System)
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- Retina
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Equatorial Lens Epithelial Cells Lens
-
Hair (Integumentary System)
- Fetal Cortex Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Fetal Matrix Cells Hair Follicle
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Paraxial Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Trunk Mesoderm
- Umbilical Cord (Extraembryonic Tissues)
- Mesenchymal Stem Cells (Uncategorized)
-
Brain (Nervous System)
- Cerebellum
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Tooth (Integumentary System)
- Stellate Reticulum Cells Dental Core
- Primary Enamel Knot Cells Enamel Knot
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Paraxial Mesoderm
- Paraxial Mesoderm Cells Trunk Mesoderm
- NULL (Uncategorized)
- Bone (Muscoskeletal System)
- Kidney (Urinary System)
- Blood (Hematopoietic System)
- Gut Tube (Gastrointestinal Tract)
-
Epidermis (Integumentary System)
- Granular Keratinocytes Stratified Epidermis
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Lung (Respiratory System)
- Bronchiolar Progenitor Cells Stem Bronchi
-
Ectoderm (Gastrulation Derivatives)
- Preplacodal Ectoderm Cells Preplacodal Ectoderm
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
mRNA differential expression in normal tissues according to GTEx for HES1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.4).
This gene is overexpressed in Blymphocyte (52.9) and Heart (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HES1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HES1 Gene:
HES1SOURCE GeneReport for Unigene cluster for HES1 Gene:
Hs.250666Evidence on tissue expression from TISSUES for HES1 Gene
- Liver(4.9)
- Kidney(4.4)
- Nervous system(2.5)
- Eye(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for HES1
-
OriGene qPCR primer pairs and template standards for HES1
- genomics-online: primer clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES1 Gene
Orthologs for HES1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HES1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HES1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hes1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hes1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HES1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HES1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHAIRY-1 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hes1 33 |
|
||
| Str.10866 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397813 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | her6 33 |
|
||
| her9 34 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.686 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | h 34 |
|
ManyToMany | |
| dpn 34 |
|
ManyToMany | |||
| Side 34 |
|
ManyToMany |
- Species where no ortholog for HES1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HES1 Gene
Variants for HES1 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001457073 | -- | 194,135,022(+) | G/C | upstream_transcript_variant | |
| rs1001888324 | -- | 194,134,901(+) | C/A/T | upstream_transcript_variant | |
| rs1002143313 | -- | 194,138,897(+) | C/T | downstream_transcript_variant | |
| rs1002257985 | -- | 194,139,102(+) | A/G | downstream_transcript_variant | |
| rs1002483272 | -- | 194,134,284(+) | CGGCGGCGGCGGCGGCG/CGGCGGCGGCGGCGGCGGCGGCG | upstream_transcript_variant |
Residual Variation Intolerance Score:
19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HES1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HES1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES1 Gene
Disorders for HES1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| medulloblastoma |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| chromosome 3q29 deletion syndrome |
|
|
| maturity-onset diabetes of the young |
|
|
Search HES1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HES1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HES1 Gene
Publications for HES1 Gene
- HES1 is a novel interactor of the Fanconi anemia core complex. (PMID: 18550849) Tremblay CS … Carreau M (Blood 2008) 3 4 22 58
- Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. (PMID: 8020957) Feder JN … Jan YN (Genomics 1994) 2 3 4 58
- SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells. (PMID: 19322650) Müller P … Ström A (Breast cancer research and treatment 2010) 3 22 58
- Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. (PMID: 19603167) Ma D … Hou M (Annals of hematology 2010) 3 22 58
- Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (PMID: 19861684) Nakahara F … Chiba S (Blood 2010) 3 22 58
Products for HES1 Gene
- R&D Systems Antibodies for HES1 (HES-1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HES1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HES1
- Search Origene for MassSpec and Protein Over-expression Lysates for HES1
- Origene Custom Protein Services for HES1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
- OriGene qPCR primer pairs and template standards for HES1
- OriGene qPCR primer pairs for HES1
- OriGene CRISPR knockouts for HES1
- OriGene ORF clones in human for HES1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HES1
- GenScript: Next-day shipping of latest version cDNA ORF clones for HES1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HES1
- GenScript Custom Assay Services for HES1
- GenScript Custom overexpressing Cell Line Services for HES1
- GenScript: Design CRISPR guide RNA sequences for HES1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HES1
- Sino Biological Human cDNA Clone for HES1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HES1
- Novus Biologicals lysates and proteins for HES1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HES1
- Abcam proteins for HES1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for HES1
- Cloud-Clone Corp. Proteins for HES1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for HES1
- VectorBuilder custom plasmid, inducible vectors for HES1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HES1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HES1
- antibodies-online: Search results for available HES1 related products ranked by validation data
- antibodies-online: Search results for available HES1 related products ranked by validation data
- antibodies-online: Search results for available HES1 related products ranked by validation data
- GeneTex HES1 antibody for HES1
- Search GeneTex for Proteins for HES1
- ViGene Biosciences adenoviral particle packaged cDNA for HES1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
- Search ViGene Biosciences for HES1
- Santa Cruz Biotechnology (SCBT) Antibodies for HES1
- Search Santa Cruz Biotechnology (SCBT) for HES1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- Horizon Cell Lines for HES1
- genomics-online: cdna clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- orf clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- genomics-online: gRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- genomics-online: primer clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
- genomics-online: shRNA clones - Search results for 113 available HES1 gene related products
- Overview of 113 available HES1 gene related products
Sources for HES1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems