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This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The ge... See more...
Aliases for HERC5 Gene
Aliases for HERC5 Gene
External Ids for HERC5 Gene
- HGNC: 24368
- Entrez Gene: 51191
- Ensembl: ENSG00000138646
- OMIM: 608242
- UniProtKB: Q9UII4
Previous GeneCards Identifiers for HERC5 Gene
- GC04P089837
- GC04P089735
- GC04P089597
- GC04P089378
- GC04P085130
Summaries for HERC5 Gene
-
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
GeneCards Summary for HERC5 Gene
HERC5 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5) is a Protein Coding gene. Diseases associated with HERC5 include Influenza. Among its related pathways are Interferon gamma signaling and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is HERC6.
UniProtKB/Swiss-Prot Summary for HERC5 Gene
-
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Additional gene information for HERC5 Gene
- HGNC(24368)
- Entrez Gene(51191)
- Ensembl(ENSG00000138646)
- OMIM(608242)
- UniProtKB(Q9UII4)
- Open Targets Platform(ENSG00000138646)
- Monarch Initiative
- Search for HERC5 at DataMed
- Search for HERC5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HERC5 Gene
Genomics for HERC5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HERC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HERC5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HERC5
- Top Transcription factor binding sites by QIAGEN in the HERC5 gene promoter:
-
- CUTL1
- FOXD3
- FOXO3
- FOXO3a
- FOXO3b
- Gfi-1
- HNF-3beta
- NF-kappaB
- NF-kappaB1
Genomic Locations for HERC5 Gene
Genomic Locations for HERC5 Gene
- chr4:88,456,604-88,506,170
- (GRCh38/hg38)
- Size:
- 49,567 bases
- Orientation:
- Plus strand
- chr4:89,378,268-89,427,314
- (GRCh37/hg19)
- Size:
- 49,047 bases
- Orientation:
- Plus strand
Genomic View for HERC5 Gene
Genes around HERC5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q22.1 by HGNC
- 4q22.1 by Entrez Gene
- 4q22.1 by Ensembl
HERC5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HERC5 Gene
Proteins for HERC5 Gene
-
Protein details for HERC5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UII4-HERC5_HUMAN
- Recommended name:
- E3 ISG15--protein ligase HERC5
- Protein Accession:
- Q9UII4
- B2RTQ1
- Q69G20
Protein attributes for HERC5 Gene
- Size:
- 1024 amino acids
- Molecular mass:
- 116852 Da
- Quaternary structure:
-
- Binds to CCNA1, CCNB1, CCND1 and CCNE1. Interacts with UBE2L6. Interacts with IRF3, this interaction is marginal in resting cells but enhanced upon viral infection. Interacts with influenza A virus NS1.
Protein Expression for HERC5 Gene
Selected DME Specific Peptides for HERC5 Gene
- Q9UII4:
-
- GQLGHNST
- YHSLALSK
Post-translational modifications for HERC5 Gene
- ISGylated.
-
Ubiquitination at Lys27 and Lys447
- NX_Q9UII4 (NX_Q9UII4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HERC5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CEB1 / HERC5 Antibody (LS-B9697) and CEB1 / HERC5 Antibody (LS-B12707)
- Novus Biologicals Antibodies for HERC5
- Invitrogen Antibodies for HERC5 (AFLGC-HERC5)
-
Boster Bio Antibodies for HERC5
Protein Products
-
OriGene Purified Proteins for HERC5
- Search Origene for MassSpec and Protein Over-expression Lysates for HERC5
- Origene Custom Protein Services for HERC5
- Novus Biologicals proteins for HERC5
- ProSpec Recombinant Proteins for HERC5
- antibodies-online: Show 4 available HERC5 Proteins ranked by validation data
- Compare Top HERC5 Proteins
-
Quality Products:
-
Abcam proteins for HERC5
Domains & Families for HERC5 Gene
Gene Families for HERC5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for HERC5 Gene
- InterPro:
- Blocks:
-
- HECT domain (Ubiquitin-protein ligase)
- Regulator of chromosome condensation, RCC1
- ProtoNet:
Suggested Antigen Peptide Sequences for HERC5 Gene
- GenScript: Design optimal peptide antigens:
-
- HECT domain and RCC1-like domain-containing protein 5 (HERC5_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HERC5 Gene
Function for HERC5 Gene
Molecular function for HERC5 Gene
- UniProtKB/Swiss-Prot Function:
- Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
- UniProtKB/Swiss-Prot Induction:
- By IFNB1/IFN-beta. In endothelial cells, by TNF, IL1B/interleukin-1B and by bacterial lipopolysaccharides (LPS), hardly induced in other cells of the vascular wall such as primary smooth muscle cells and fibroblasts. By viral infection.
Enzyme Numbers (IUBMB) for HERC5 Gene
Phenotypes From GWAS Catalog for HERC5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004842 | ubiquitin-protein transferase activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IPI | 20133869 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0042296 | ISG15 transferase activity | IDA | 20308324 |
Phenotypes for HERC5 Gene
- GenomeRNAi human phenotypes for HERC5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HERC5 - Select products 50% OFF >
- * HERC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HERC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HERC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC5
miRNA for HERC5 Gene
- miRTarBase miRNAs that target HERC5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HERC5
- Browse OriGene Inhibitory RNA Products For HERC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HERC5
Clone Products
- Applied Biological Materials (abm): Clones for HERC5 - Select products 50% OFF >
- * HERC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HERC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HERC5
Cell Line Products
-
Horizon Cell Lines for HERC5
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HERC5 Gene
Localization for HERC5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HERC5 Gene
- Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 10581175 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HERC5 Gene
Pathways & Interactions for HERC5 Gene
Pathways by source for HERC5 Gene
Interacting Proteins for HERC5 Gene
Selected Interacting proteins:
Q9UII4-HERC5_HUMAN
ENSP00000264350
for HERC5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HERC5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | 10581175 |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA,IDA | 15331633 |
| GO:0032020 | ISG15-protein conjugation | IDA | 20308324 |
No data available for SIGNOR curated interactions for HERC5 Gene
Transcripts for HERC5 Gene
mRNA/cDNA for HERC5 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264350 3511 nts (view in UCSC)
- ENST00000502913 1949 nts (view in UCSC)
- ENST00000508159 2243 nts (view in UCSC)
- ENST00000508695 543 nts (view in UCSC)
- ENST00000510223 2925 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HERC5 - Select products 50% OFF >
- * HERC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HERC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HERC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HERC5
- Browse OriGene Inhibitory RNA Products For HERC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HERC5
Clone Products
- Applied Biological Materials (abm): Clones for HERC5 - Select products 50% OFF >
- * HERC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HERC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HERC5
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 24b | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: |
Relevant External Links for HERC5 Gene
- GeneLoc Exon Structure for
- HERC5
Expression for HERC5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for HERC5 Gene
This gene is overexpressed in Testis (x7.8).
This gene is overexpressed in Fetal ovary (28.0), Ovary (20.2), and Testis (18.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HERC5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HERC5
SOURCE GeneReport for Unigene cluster for HERC5 Gene:
Hs.26663mRNA Expression by UniProt/SwissProt for HERC5 Gene:
Q9UII4-HERC5_HUMAN
Tissue specificity:
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Evidence on tissue expression from TISSUES for HERC5 Gene
- Nervous system(4.4)
- Blood(2.2)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for HERC5
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HERC5 Gene
Orthologs for HERC5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HERC5 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | HERC5 (4 of 4) 31 |
|
OneToMany | |
| HERC5 (3 of 4) 31 |
|
OneToMany | |||
| HERC5 (1 of 4) 31 |
|
OneToMany | |||
| HERC5 (2 of 4) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6678 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | K11D2.1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATS1 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for HERC5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for HERC5 Gene
- ENSEMBL:
- Gene Tree for HERC5 (if available)
- TreeFam:
- Gene Tree for HERC5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HERC5: view image
Paralogs for HERC5 Gene
Paralogs for HERC5 Gene
(6) SIMAP similar genes for HERC5 Gene using alignment to 2 proteins:
- HERC5_HUMAN
- E9PBL0_HUMAN
Variants for HERC5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HERC5 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 780486 | Benign: not provided | 88,463,975(+) | G/A | MISSENSE_VARIANT | |
| 782444 | Benign: not provided | 88,469,243(+) | G/A | SYNONYMOUS_VARIANT | |
| 789471 | Benign: not provided | 88,463,979(+) | G/C | MISSENSE_VARIANT | |
| rs17014143 | - | p.Ala301Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1112857 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.31;
62.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HERC5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HERC5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERC5 Gene
Disorders for HERC5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| influenza |
|
|
Search HERC5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HERC5
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HERC5 Gene
Publications for HERC5 Gene
- HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PMID: 16815975) Wong JJ … Chin KC (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23
- HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. (PMID: 15331633) Kroismayr R … Lipp J (Journal of cell science 2004) 3 4 23
- A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. (PMID: 10581175) Mitsui K … Ohtsubo M (Biochemical and biophysical research communications 1999) 2 3 4
- Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 3 41
- Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. (PMID: 20308324) Shi HX … Wang C (Molecular and cellular biology 2010) 3 4
ExternalLinks
Products for HERC5 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HERC5
- Search Origene for MassSpec and Protein Over-expression Lysates for HERC5
- Origene Custom Protein Services for HERC5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HERC5
- Browse OriGene Inhibitory RNA Products For HERC5
- OriGene qPCR primer pairs for HERC5
- OriGene CRISPR knockouts for HERC5
- OriGene ORF clones in human for HERC5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HERC5
- Sino Biological Human cDNA Clone for HERC5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HERC5
- Novus Biologicals proteins for HERC5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for HERC5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for HERC5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HERC5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HERC5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HERC5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HERC5
- antibodies-online: Show 7 available HERC5 Antibodies ranked by validation data
- Compare Top HERC5 Antibodies
- antibodies-online: Search results for available HERC5 related products ranked by validation data
- antibodies-online: Show 4 available HERC5 Proteins ranked by validation data
- Compare Top HERC5 Proteins
- Quality Products:
- Horizon Cell Lines for HERC5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HERC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HERC5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HERC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HERC5
- Boster Bio Antibodies for HERC5
- Browse Boster Bio ELISA Kits
Sources for HERC5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
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