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This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
HERC5 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5) is a Protein Coding gene. Diseases associated with HERC5 include Influenza. Among its related pathways are Interferon gamma signaling and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is HERC6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004842 | ubiquitin-protein transferase activity | IEA,TAS | -- |
GO:0005515 | protein binding | IPI | 20133869 |
GO:0016740 | transferase activity | IEA | -- |
GO:0042296 | ISG15 transferase activity | IDA | 20308324 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 10581175 |
GO:0005829 | cytosol | TAS | -- |
GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | 10581175 |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0016567 | protein ubiquitination | IEA,IDA | 15331633 |
GO:0032020 | ISG15-protein conjugation | IDA | 20308324 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 24b | ^ | 25 | ^ | 26 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HERC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HERC5 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | HERC5 (4 of 4) 31 |
|
OneToMany | |
HERC5 (3 of 4) 31 |
|
OneToMany | |||
HERC5 (1 of 4) 31 |
|
OneToMany | |||
HERC5 (2 of 4) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6678 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | K11D2.1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATS1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780486 | Benign: not provided | 88,463,975(+) | G/A | MISSENSE_VARIANT | |
782444 | Benign: not provided | 88,469,243(+) | G/A | SYNONYMOUS_VARIANT | |
789471 | Benign: not provided | 88,463,979(+) | G/C | MISSENSE_VARIANT | |
rs17014143 | - | p.Ala301Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1112857 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
influenza |
|
|