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This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
HERC3 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Diseases associated with HERC3 include Epidural Abscess. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000287542.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Ubiquitin mediated proteolysis | ||
3 | Innate Immune System |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HERC3 30 |
|
||
Dog (Canis familiaris) |
Mammalia | HERC3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HERC3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HERC3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Herc3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Herc3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | HERC3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HERC3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | herc3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | herc3 30 31 |
|
OneToOne | |
Dr.16537 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7420 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9153 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | herc-1 30 31 |
|
OneToMany | |
Y48G8AL.1 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HUL4 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2850n106 | CNV | deletion | 24896259 |
esv1953449 | CNV | deletion | 18987734 |
esv2278581 | CNV | deletion | 18987734 |
esv2640318 | CNV | deletion | 19546169 |
esv2657218 | CNV | deletion | 23128226 |
esv2727952 | CNV | deletion | 23290073 |
esv2727953 | CNV | deletion | 23290073 |
esv3564216 | CNV | deletion | 23714750 |
esv5387 | CNV | loss | 18987735 |
nsv1073354 | CNV | deletion | 25765185 |
nsv291508 | CNV | deletion | 16902084 |
nsv461575 | CNV | gain | 19166990 |
nsv461576 | CNV | gain | 19166990 |
nsv594805 | CNV | gain | 21841781 |
nsv594806 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
epidural abscess |
|
|