Aliases for HEPACAM2 Gene
External Ids for HEPACAM2 Gene
Previous GeneCards Identifiers for HEPACAM2 Gene
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]
GeneCards Summary for HEPACAM2 Gene
HEPACAM2 (HEPACAM Family Member 2) is a Protein Coding gene. Diseases associated with HEPACAM2 include Retinitis Pigmentosa 32 and Myelodysplastic Syndrome. An important paralog of this gene is HEPACAM.
UniProtKB/Swiss-Prot Summary for HEPACAM2 Gene
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.