Aliases for HENMT1 Gene

Aliases for HENMT1 Gene

  • HEN Methyltransferase 1 2 3 5
  • HEN1 Methyltransferase Homolog 1 2 3 4
  • Small RNA 2'-O-Methyltransferase 3 4
  • C1orf59 3 4
  • HEN1 Methyltransferase Homolog 1 (Arabidopsis) 2
  • Hua Enhancer 1 Homolog 1 (Arabidopsis) 2
  • Chromosome 1 Open Reading Frame 59 2
  • Hua Enhancer 1 Homolog 1 3
  • EC 2.1.1.n8 4
  • HEN1 3

External Ids for HENMT1 Gene

Previous HGNC Symbols for HENMT1 Gene

  • C1orf59

Previous GeneCards Identifiers for HENMT1 Gene

  • GC01M109191

Summaries for HENMT1 Gene

GeneCards Summary for HENMT1 Gene

HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot Summary for HENMT1 Gene

  • Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

Additional gene information for HENMT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HENMT1 Gene

Genomics for HENMT1 Gene

GeneHancer (GH) Regulatory Elements for HENMT1 Gene

Promoters and enhancers for HENMT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J108660 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 755 +0.2 205 2.6 ZNF24 POLR2A MYC MAX MNT MLLT1 ZNF687 CREM CREB1 NRF1 HENMT1 ENSG00000285923 LOC105378890 PRPF38B piR-50443-024
GH01J108662 Enhancer 0.3 ENCODE dbSUPER 750.6 -1.2 -1157 0 ENSG00000285923 HENMT1 LOC105378890 PRPF38B piR-31470-025
GH01J108583 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.5 +76.5 76491 3.8 SMARCE1 POLR2A HLF ZNF652 ELF3 SMARCA4 PRDM1 DPF2 IKZF1 PKNOX1 FAM102B PRPF38B HENMT1 STXBP3 piR-55361-031 piR-50443-024
GH01J108703 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.8 -42.6 -42630 2.3 ZBTB40 SMARCE1 CC2D1A ELF1 HLF MAFK MLLT1 SMARCA4 MCM2 IKZF1 ENSG00000232971 HENMT1 PRPF38B FAM102B TMEM167B FNDC7 NONHSAG002311.2
GH01J108589 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.5 +70.3 70276 3.4 ZBTB40 POLR2A RFX1 CEBPB JUN RCOR1 JUND MAX EP300 BMI1 PRPF38B HENMT1 FAM102B TMEM167B STXBP3 piR-55361-031 piR-50443-024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HENMT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HENMT1 Gene

Genomic Locations for HENMT1 Gene
chr1:108,648,288-108,661,526
(GRCh38/hg38)
Size:
13,239 bases
Orientation:
Minus strand
chr1:109,190,910-109,204,148
(GRCh37/hg19)
Size:
13,239 bases
Orientation:
Minus strand

Genomic View for HENMT1 Gene

Genes around HENMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HENMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HENMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HENMT1 Gene

Proteins for HENMT1 Gene

  • Protein details for HENMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8I9-HENMT_HUMAN
    Recommended name:
    Small RNA 2'-O-methyltransferase
    Protein Accession:
    Q5T8I9
    Secondary Accessions:
    • A8MRR6
    • B1AM16
    • B1AM17
    • Q96EJ7
    • Q96NN0

    Protein attributes for HENMT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44525 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HENMT1 Gene

neXtProt entry for HENMT1 Gene

Post-translational modifications for HENMT1 Gene

  • Ubiquitination at Lys100, Lys235, Lys308, Lys325, and Lys338
  • Modification sites at PhosphoSitePlus

Other Protein References for HENMT1 Gene

No data available for DME Specific Peptides for HENMT1 Gene

Domains & Families for HENMT1 Gene

Gene Families for HENMT1 Gene

Protein Domains for HENMT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HENMT1 Gene

GenScript: Design optimal peptide antigens:
  • HEN1 methyltransferase homolog 1 (HENMT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T8I9

UniProtKB/Swiss-Prot:

HENMT_HUMAN :
  • Belongs to the methyltransferase superfamily. HEN1 family.
Family:
  • Belongs to the methyltransferase superfamily. HEN1 family.
genes like me logo Genes that share domains with HENMT1: view

Function for HENMT1 Gene

Molecular function for HENMT1 Gene

UniProtKB/Swiss-Prot Function:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide; Xref=Rhea:RHEA:37887, Rhea:RHEA-COMP:10415, Rhea:RHEA-COMP:10416, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74896, ChEBI:CHEBI:74898; EC=2.1.1.n8; Evidence=. ;.

Enzyme Numbers (IUBMB) for HENMT1 Gene

Gene Ontology (GO) - Molecular Function for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity ISS --
GO:0008173 RNA methyltransferase activity ISS,IBA --
genes like me logo Genes that share ontologies with HENMT1: view
genes like me logo Genes that share phenotypes with HENMT1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for HENMT1 Gene

Selected GeneGlobe predicted Target genes for HENMT1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HENMT1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for HENMT1 Gene

Localization for HENMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HENMT1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q568P9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HENMT1 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with HENMT1: view

Pathways & Interactions for HENMT1 Gene

genes like me logo Genes that share pathways with HENMT1: view

Pathways by source for HENMT1 Gene

Gene Ontology (GO) - Biological Process for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation ISS --
GO:0030422 production of siRNA involved in RNA interference IBA 21873635
GO:0031047 gene silencing by RNA IEA --
GO:0032259 methylation IEA --
GO:0034587 piRNA metabolic process ISS,IBA --
genes like me logo Genes that share ontologies with HENMT1: view

No data available for SIGNOR curated interactions for HENMT1 Gene

Drugs & Compounds for HENMT1 Gene

(1) Drugs for HENMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for HENMT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with HENMT1: view

Transcripts for HENMT1 Gene

mRNA/cDNA for HENMT1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HENMT1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HENMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for HENMT1 Gene

GeneLoc Exon Structure for
HENMT1
ECgene alternative splicing isoforms for
HENMT1

Expression for HENMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HENMT1 Gene

mRNA differential expression in normal tissues according to GTEx for HENMT1 Gene

This gene is overexpressed in Testis (x9.1).

Protein differential expression in normal tissues from HIPED for HENMT1 Gene

This gene is overexpressed in Testis (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HENMT1 Gene



Protein tissue co-expression partners for HENMT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HENMT1 Gene:

HENMT1

SOURCE GeneReport for Unigene cluster for HENMT1 Gene:

Hs.7962

Evidence on tissue expression from TISSUES for HENMT1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with HENMT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HENMT1 Gene

Orthologs for HENMT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HENMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HENMT1 33 32
  • 99.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Henmt1 32
  • 76.76 (n)
mouse
(Mus musculus)
Mammalia Henmt1 17 33 32
  • 76.13 (n)
cow
(Bos Taurus)
Mammalia HENMT1 33 32
  • 73.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479920 32
  • 70.05 (n)
HENMT1 33
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 58 (a)
OneToMany
-- 33
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HENMT1 33
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves HENMT1 33 32
  • 57.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HENMT1 33
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia henmt1 32
  • 53.99 (n)
zebrafish
(Danio rerio)
Actinopterygii henmt1 33 32
  • 50.87 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hen1 33 32
  • 44.96 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea henn-1 33
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.976 33
  • 20 (a)
OneToOne
Species where no ortholog for HENMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HENMT1 Gene

ENSEMBL:
Gene Tree for HENMT1 (if available)
TreeFam:
Gene Tree for HENMT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HENMT1: view image

Paralogs for HENMT1 Gene

No data available for Paralogs for HENMT1 Gene

Variants for HENMT1 Gene

Sequence variations from dbSNP and Humsavar for HENMT1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000149852 -- 108,662,199(-) C/G/T upstream_transcript_variant
rs1000233564 -- 108,657,757(-) T/TT intron_variant
rs1000237633 -- 108,656,864(-) T/C/G intron_variant
rs1000663176 -- 108,661,670(-) C/T upstream_transcript_variant
rs1000820354 -- 108,661,883(-) G/T upstream_transcript_variant

Variation tolerance for HENMT1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HENMT1 Gene

Human Gene Mutation Database (HGMD)
HENMT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HENMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HENMT1 Gene

Disorders for HENMT1 Gene

Additional Disease Information for HENMT1

No disorders were found for HENMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HENMT1 Gene

Publications for HENMT1 Gene

  1. HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. (PMID: 26496356) Lim SL … O'Bryan MK (PLoS genetics 2015) 2 3 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain. (PMID: 29703750) Peng L … Huang Y (The Journal of biological chemistry 2018) 3 56
  4. Photoelectrochemical biosensor for HEN1 RNA methyltransferase detection using peroxidase mimics PtCu NFs and poly(U) polymerase-mediated RNA extension. (PMID: 29277012) Wang H … Ai S (Biosensors & bioelectronics 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for HENMT1 Gene

Sources for HENMT1 Gene