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HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include RNA binding and RNA methyltransferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 22458338 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0008171 | O-methyltransferase activity | IEA,ISS | -- |
GO:0008173 | RNA methyltransferase activity | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0043186 | P granule | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Mitotic Prophase | ||
3 | PIWI-interacting RNA (piRNA) biogenesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001510 | RNA methylation | IEA,ISS | -- |
GO:0030422 | production of siRNA involved in RNA interference | IBA | 21873635 |
GO:0031047 | gene silencing by RNA | IEA | -- |
GO:0032259 | methylation | IEA | -- |
GO:0034587 | piRNA metabolic process | IBA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
s-adenosylhomocysteine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HENMT1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Henmt1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Henmt1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HENMT1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC479920 30 |
|
||
HENMT1 31 |
|
OneToOne | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | HENMT1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HENMT1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HENMT1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | henmt1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | henmt1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Hen1 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | henn-1 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.976 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs111789685 | Benign: not provided | 108,657,487(-) |
G/A NM_001102592.2(HENMT1):c.114C>T (p.Phe38=) |
SYNONYMOUS | |
rs115379157 | Benign: not provided | 108,648,676(-) |
T/C NM_001102592.2(HENMT1):c.1072A>G (p.Asn358Asp) |
MISSENSE | |
rs35974434 | Benign: not provided. - | 108,650,278(-) |
C/Tp.Arg230Gln NM_001102592.2(HENMT1):c.689G>A (p.Arg230Gln) |
MISSENSE | |
rs17850887 | - |
p.Met361Ile |
|||
rs9988420 | - |
p.Thr129Ala |
No disorders were found for HENMT1 Gene.