HENMT1 Gene (Protein Coding)

HEN Methyltransferase 1

GC01M108648
GIFtS:
34
See more...

Aliases for HENMT1 Gene

Aliases for HENMT1 Gene

  • HEN Methyltransferase 1 2 3 5
  • HEN1 Methyltransferase Homolog 1 2 3 4
  • Small RNA 2'-O-Methyltransferase 3 4
  • C1orf59 3 4
  • HEN1 2 3
  • HEN1 Methyltransferase Homolog 1 (Arabidopsis) 2
  • Hua Enhancer 1 Homolog 1 (Arabidopsis) 2
  • Chromosome 1 Open Reading Frame 59 2
  • Hua Enhancer 1 Homolog 1 3
  • EC 2.1.1.n8 4
  • FLJ30525 2
  • HENMT1 5

External Ids for HENMT1 Gene

Previous HGNC Symbols for HENMT1 Gene

  • C1orf59

Previous GeneCards Identifiers for HENMT1 Gene

  • GC01M109191

Summaries for HENMT1 Gene

GeneCards Summary for HENMT1 Gene

HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot Summary for HENMT1 Gene

  • Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

Additional gene information for HENMT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HENMT1 Gene

Genomics for HENMT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HENMT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HENMT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HENMT1

Genomic Locations for HENMT1 Gene

Latest Assembly
chr1:108,648,290-108,661,526
(GRCh38/hg38)
Size:
13,237 bases
Orientation:
Minus strand

Previous Assembly
chr1:109,190,917-109,204,096
(GRCh37/hg19 by Entrez Gene)
Size:
13,180 bases
Orientation:
Minus strand

chr1:109,190,912-109,204,148
(GRCh37/hg19 by Ensembl)
Size:
13,237 bases
Orientation:
Minus strand

Genomic View for HENMT1 Gene

Genes around HENMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HENMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HENMT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HENMT1 Gene

Proteins for HENMT1 Gene

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  • Protein details for HENMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8I9-HENMT_HUMAN
    Recommended name:
    Small RNA 2'-O-methyltransferase
    Protein Accession:
    Q5T8I9
    Secondary Accessions:
    • A8MRR6
    • B1AM16
    • B1AM17
    • Q96EJ7
    • Q96NN0

    Protein attributes for HENMT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44525 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HENMT1 Gene

neXtProt entry for HENMT1 Gene

Protein Expression for HENMT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HENMT1 Gene

  • Ubiquitination at Lys100, Lys235, Lys308, Lys325, and Lys338
  • Modification sites at PhosphoSitePlus

Other Protein References for HENMT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HENMT1 Gene

Domains & Families for HENMT1 Gene

Gene Families for HENMT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HENMT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HENMT1 Gene

GenScript: Design optimal peptide antigens:
  • HEN1 methyltransferase homolog 1 (HENMT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T8I9

UniProtKB/Swiss-Prot:

HENMT_HUMAN :
  • Belongs to the methyltransferase superfamily. HEN1 family.
Family:
  • Belongs to the methyltransferase superfamily. HEN1 family.
genes like me logo Genes that share domains with HENMT1: view

Function for HENMT1 Gene

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  6. Cell Lines for research

Molecular function for HENMT1 Gene

UniProtKB/Swiss-Prot Function:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide; Xref=Rhea:RHEA:37887, Rhea:RHEA-COMP:10415, Rhea:RHEA-COMP:10416, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74896, ChEBI:CHEBI:74898; EC=2.1.1.n8; Evidence={ECO:0000250|UniProtKB:Q8CAE2};.

Enzyme Numbers (IUBMB) for HENMT1 Gene

Gene Ontology (GO) - Molecular Function for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity IEA,ISS --
GO:0008173 RNA methyltransferase activity IEA,ISS --
genes like me logo Genes that share ontologies with HENMT1: view
genes like me logo Genes that share phenotypes with HENMT1: view

Animal Models for research

Transcription Factor Targets for HENMT1 Gene

Selected GeneGlobe predicted Target genes for HENMT1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HENMT1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for HENMT1 Gene

Localization for HENMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HENMT1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q568P9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HENMT1 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with HENMT1: view

Pathways & Interactions for HENMT1 Gene

genes like me logo Genes that share pathways with HENMT1: view

Pathways by source for HENMT1 Gene

Gene Ontology (GO) - Biological Process for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IEA,ISS --
GO:0030422 production of siRNA involved in RNA interference IBA 21873635
GO:0031047 gene silencing by RNA IEA --
GO:0032259 methylation IEA --
GO:0034587 piRNA metabolic process IBA,ISS --
genes like me logo Genes that share ontologies with HENMT1: view

No data available for SIGNOR curated interactions for HENMT1 Gene

Drugs & Compounds for HENMT1 Gene

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(1) Drugs for HENMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for HENMT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
genes like me logo Genes that share compounds with HENMT1: view

Transcripts for HENMT1 Gene

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mRNA/cDNA for HENMT1 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HENMT1

Alternative Splicing Database (ASD) splice patterns (SP) for HENMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for HENMT1 Gene

GeneLoc Exon Structure for
HENMT1

Expression for HENMT1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HENMT1 Gene

mRNA expression in normal human tissues for HENMT1 Gene
mRNA expression by GTEx for HENMT1 GenemRNA expression by BioGPS for HENMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for HENMT1 Gene

This gene is overexpressed in Testis (x9.1).

Protein differential expression in normal tissues from HIPED for HENMT1 Gene

This gene is overexpressed in Testis (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HENMT1 Gene



Protein tissue co-expression partners for HENMT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HENMT1

SOURCE GeneReport for Unigene cluster for HENMT1 Gene:

Hs.7962

Evidence on tissue expression from TISSUES for HENMT1 Gene

  • Nervous system(4.6)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with HENMT1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HENMT1 Gene

Orthologs for HENMT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HENMT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HENMT1 30 31
  • 99.83 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Henmt1 30
  • 76.76 (n)
Mouse
(Mus musculus)
 Mammalia Henmt1 30 17 31
  • 76.13 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia HENMT1 30 31
  • 73.86 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LOC479920 30
  • 70.05 (n)
HENMT1 31
  • 56 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 58 (a)
 OneToMany
-- 31
  • 32 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia HENMT1 31
  • 45 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves HENMT1 30 31
  • 57.14 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia HENMT1 31
  • 45 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia henmt1 30
  • 53.99 (n)
Zebrafish
(Danio rerio)
 Actinopterygii henmt1 30 31
  • 50.87 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Hen1 30 31
  • 44.96 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea henn-1 31
  • 16 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.976 31
  • 20 (a)
 OneToOne
Species where no ortholog for HENMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HENMT1 Gene

ENSEMBL:
Gene Tree for HENMT1 (if available)
TreeFam:
Gene Tree for HENMT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HENMT1: view image

Paralogs for HENMT1 Gene

No data available for Paralogs for HENMT1 Gene

Variants for HENMT1 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HENMT1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs111789685 Benign: not provided 108,657,487(-) G/A
NM_001102592.2(HENMT1):c.114C>T (p.Phe38=) 		SYNONYMOUS
rs115379157 Benign: not provided 108,648,676(-) T/C
NM_001102592.2(HENMT1):c.1072A>G (p.Asn358Asp) 		MISSENSE
rs35974434 Benign: not provided. - 108,650,278(-) C/Tp.Arg230Gln
NM_001102592.2(HENMT1):c.689G>A (p.Arg230Gln) 		MISSENSE
rs17850887 - p.Met361Ile
rs9988420 - p.Thr129Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HENMT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for HENMT1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HENMT1 Gene

Human Gene Mutation Database (HGMD)
HENMT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HENMT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HENMT1 Gene

Disorders for HENMT1 Gene

Additional Disease Information for HENMT1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for HENMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HENMT1 Gene

Publications for HENMT1 Gene

  1. HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. (PMID: 26496356) Lim SL … O'Bryan MK (PLoS genetics 2015) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain. (PMID: 29703750) Peng L … Huang Y (The Journal of biological chemistry 2018) 3
  5. Photoelectrochemical biosensor for HEN1 RNA methyltransferase detection using peroxidase mimics PtCu NFs and poly(U) polymerase-mediated RNA extension. (PMID: 29277012) Wang H … Ai S (Biosensors & bioelectronics 2018) 3

ExternalLinks

View latest publications for HENMT1 gene in Mastermind

Products for HENMT1 Gene

Sources for HENMT1 Gene