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Aliases for HELZ2 Gene

Aliases for HELZ2 Gene

  • Helicase With Zinc Finger 2 2 3 5
  • Helicase With Zinc Finger 2, Transcriptional Coactivator 2 3 4
  • Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 KDa Protein 3 4
  • PPAR-Gamma DNA-Binding Domain-Interacting Protein 1 3 4
  • PPAR-Alpha-Interacting Complex Protein 285 3 4
  • PPARG-DBD-Interacting Protein 1 2 3
  • ATP-Dependent Helicase PRIC285 3 4
  • PRIC285 3 4
  • PDIP1 3 4
  • Peroxisomal Proliferator-Activated Receptor Alpha-Interacting Cofactor Complex, 285 KD Subunit 3
  • Peroxisomal Proliferator Activated Receptor A Interacting Complex 285 2
  • Peroxisomal Proliferator-Activated Receptor A Interacting Complex 285 3
  • PPARgamma-DNA-Binding Domain-Interacting Protein1 3
  • PPAR Gamma DBD-Interacting Protein 1 3
  • PPAR-Gamma DBD-Interacting Protein 1 4
  • Helicase With Zinc Finger Domain 2 3
  • PRIC Complex 3
  • EC 3.6.4.- 4
  • KIAA1769 4
  • PDIP-1 3

External Ids for HELZ2 Gene

Previous GeneCards Identifiers for HELZ2 Gene

  • GC20M062190

Summaries for HELZ2 Gene

Entrez Gene Summary for HELZ2 Gene

  • The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HELZ2 Gene

HELZ2 (Helicase With Zinc Finger 2) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is HELZ.

UniProtKB/Swiss-Prot for HELZ2 Gene

  • Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.

Gene Wiki entry for HELZ2 Gene

Additional gene information for HELZ2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ2 Gene

Genomics for HELZ2 Gene

GeneHancer (GH) Regulatory Elements for HELZ2 Gene

Promoters and enhancers for HELZ2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I063573 Promoter/Enhancer 1.5 Ensembl ENCODE 550.8 0.0 -32 2.9 ARID4B SIN3A DMAP1 ZBTB7B ZNF121 GLIS2 ZNF143 KLF7 ATF7 SP3 HELZ2 PIR55174 GMEB2 GC20M063599
GH20I063566 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.4 +6.0 6021 2.5 CTCF CHD4 MAX EBF1 BATF KLF5 RELA ZKSCAN1 HIC1 POLR2A PIR35506 GC20M063568 HELZ2 RGS19 UCKL1 GMEB2 RTEL1 PIR55174
GH20I063575 Enhancer 0.8 ENCODE 550.8 -1.8 -1845 0.7 NFIB INSM2 DMAP1 ZNF121 GLIS2 ZSCAN5C ATF7 THAP11 CEBPB ZNF398 HELZ2 FNDC11 SRMS ZBTB46-AS1 GC20M063599
GH20I063572 Promoter 0.6 EPDnew 550.8 +1.8 1799 0.1 SCRT2 HELZ2 PIR55174 PIR35506 GC20M063568
GH20I063893 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 -322.5 -322452 5.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 DNAJC5 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HELZ2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HELZ2 Gene

Genomic Locations for HELZ2 Gene
16,154 bases
Minus strand

Genomic View for HELZ2 Gene

Genes around HELZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HELZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HELZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELZ2 Gene

Proteins for HELZ2 Gene

  • Protein details for HELZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helicase with zinc finger domain 2
    Protein Accession:
    Secondary Accessions:
    • Q3C2G2
    • Q4VXQ1
    • Q8TEF3
    • Q96ND3
    • Q9C094

    Protein attributes for HELZ2 Gene

    2649 amino acids
    Molecular mass:
    294651 Da
    Quaternary structure:
    • Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional activity of PPARA and PPARG. Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3 synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC).
    • Sequence=BAB70969.1; Type=Frameshift; Positions=2206; Evidence={ECO:0000305};

    Alternative splice isoforms for HELZ2 Gene


neXtProt entry for HELZ2 Gene

Post-translational modifications for HELZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HELZ2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HELZ2 Gene

Domains & Families for HELZ2 Gene

Gene Families for HELZ2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HELZ2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.
  • Belongs to the DNA2/NAM7 helicase family.
  • Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.
  • Belongs to the DNA2/NAM7 helicase family.
genes like me logo Genes that share domains with HELZ2: view

Function for HELZ2 Gene

Molecular function for HELZ2 Gene

UniProtKB/Swiss-Prot Function:
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.

Enzyme Numbers (IUBMB) for HELZ2 Gene

Phenotypes From GWAS Catalog for HELZ2 Gene

Gene Ontology (GO) - Molecular Function for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IDA 22658674
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16239304
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HELZ2: view
genes like me logo Genes that share phenotypes with HELZ2: view

Animal Models for HELZ2 Gene

MGI Knock Outs for HELZ2:

miRNA for HELZ2 Gene

miRTarBase miRNAs that target HELZ2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HELZ2 Gene

Localization for HELZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELZ2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HELZ2 gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with HELZ2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HELZ2 Gene

Pathways & Interactions for HELZ2 Gene

genes like me logo Genes that share pathways with HELZ2: view

Gene Ontology (GO) - Biological Process for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019216 regulation of lipid metabolic process TAS --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 16239304
genes like me logo Genes that share ontologies with HELZ2: view

No data available for SIGNOR curated interactions for HELZ2 Gene

Drugs & Compounds for HELZ2 Gene

No Compound Related Data Available

Transcripts for HELZ2 Gene

Unigene Clusters for HELZ2 Gene

Helicase with zinc finger 2, transcriptional coactivator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21
SP1: -
SP2: -
SP4: - - - - - -

Relevant External Links for HELZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HELZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HELZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HELZ2 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for HELZ2 Gene

This gene is overexpressed in Breast (25.0), Serum (17.2), and Synovial fluid (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HELZ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HELZ2 Gene:


SOURCE GeneReport for Unigene cluster for HELZ2 Gene:


mRNA Expression by UniProt/SwissProt for HELZ2 Gene:

Tissue specificity: Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.

Evidence on tissue expression from TISSUES for HELZ2 Gene

  • Liver(4.2)
  • Spleen(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HELZ2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HELZ2 Gene

Orthologs for HELZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HELZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HELZ2 33 34
  • 98.83 (n)
(Canis familiaris)
Mammalia HELZ2 33 34
  • 80.61 (n)
(Rattus norvegicus)
Mammalia Helz2 33
  • 75.58 (n)
(Mus musculus)
Mammalia Helz2 33 16 34
  • 74.98 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
-- 34
  • 53 (a)
(Monodelphis domestica)
Mammalia HELZ2 34
  • 50 (a)
(Gallus gallus)
Aves HELZ2 33 34
  • 59.67 (n)
(Anolis carolinensis)
Reptilia HELZ2 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733680 33
  • 55.12 (n)
(Danio rerio)
Actinopterygii LOC562461 33
  • 48.63 (n)
HELZ2 (1 of 3) 34
  • 47 (a)
helz2 34
  • 37 (a)
HELZ2 (2 of 3) 34
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.71 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 34
  • 22 (a)
Species where no ortholog for HELZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELZ2 Gene

Gene Tree for HELZ2 (if available)
Gene Tree for HELZ2 (if available)

Paralogs for HELZ2 Gene

Paralogs for HELZ2 Gene

(2) SIMAP similar genes for HELZ2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HELZ2: view

Variants for HELZ2 Gene

Sequence variations from dbSNP and Humsavar for HELZ2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000070693 -- 63,566,417(-) G/A coding_sequence_variant, synonymous_variant
rs1000230439 -- 63,558,447(-) G/A 3_prime_UTR_variant
rs1000364542 -- 63,562,883(-) T/C coding_sequence_variant, missense_variant
rs1000568893 -- 63,564,420(-) G/A coding_sequence_variant, missense_variant
rs1000708819 -- 63,559,958(-) T/A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for HELZ2 Gene

Variant ID Type Subtype PubMed ID
dgv35n64 CNV loss 17921354
dgv521n27 CNV loss 19166990
dgv522n27 CNV loss 19166990
dgv679e201 CNV deletion 23290073
dgv7667n54 CNV loss 21841781
dgv7668n54 CNV loss 21841781
dgv7669n54 CNV loss 21841781
esv1000908 CNV insertion 20482838
esv1272786 CNV insertion 17803354
esv1344882 CNV insertion 17803354
esv24758 CNV gain 19812545
esv2674115 CNV deletion 23128226
esv2722937 CNV deletion 23290073
esv2722938 CNV deletion 23290073
esv2722943 CNV deletion 23290073
esv2722944 CNV deletion 23290073
esv2722945 CNV deletion 23290073
esv2758806 CNV gain+loss 17122850
esv3336842 CNV duplication 20981092
nsv1148402 CNV deletion 26484159
nsv179406 CNV insertion 16902084
nsv470563 CNV loss 18288195
nsv473307 CNV novel sequence insertion 20440878
nsv517702 CNV loss 19592680
nsv521734 CNV loss 19592680
nsv586571 CNV loss 21841781
nsv586573 CNV loss 21841781
nsv586578 CNV loss 21841781
nsv834034 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for HELZ2 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.40; 95.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HELZ2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELZ2 Gene

Disorders for HELZ2 Gene

Additional Disease Information for HELZ2

No disorders were found for HELZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HELZ2 Gene

Publications for HELZ2 Gene

  1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. (PMID: 16239304) Tomaru T … Mori M (Endocrinology 2006) 2 3 4 22 58
  2. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. (PMID: 12189208) Surapureddi S … Reddy JK (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  4. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PMID: 23525231) Katano-Toki A … Mori M (Molecular endocrinology (Baltimore, Md.) 2013) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for HELZ2 Gene

Sources for HELZ2 Gene

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