This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified... See more...

Aliases for HELLS Gene

Aliases for HELLS Gene

  • Helicase, Lymphoid Specific 2 3 5
  • Proliferation-Associated SNF2-Like Protein 2 3 4
  • SWI/SNF2-Related, Matrix-Associated, Actin-Dependent Regulator Of Chromatin, Subfamily A, Member 6 2 3
  • Lymphoid-Specific Helicase 3 4
  • SMARCA6 3 4
  • PASG 3 4
  • SWI/SNF2-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 6 4
  • EC 3.6.4.- 4
  • Nbla10143 3
  • EC 3.6.1 52
  • ICF4 3
  • LSH 3

External Ids for HELLS Gene

Previous GeneCards Identifiers for HELLS Gene

  • GC10P095198
  • GC10P095539
  • GC10P096436
  • GC10P095970
  • GC10P096295
  • GC10P096261
  • GC10P089932
  • GC10P096305

Summaries for HELLS Gene

Entrez Gene Summary for HELLS Gene

  • This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

GeneCards Summary for HELLS Gene

HELLS (Helicase, Lymphoid Specific) is a Protein Coding gene. Diseases associated with HELLS include Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 4 and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is SMARCA5.

UniProtKB/Swiss-Prot Summary for HELLS Gene

  • Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).

Gene Wiki entry for HELLS Gene

Additional gene information for HELLS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HELLS Gene

Genomics for HELLS Gene

GeneHancer (GH) Regulatory Elements for HELLS Gene

Promoters and enhancers for HELLS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J094543 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 514.7 +44.2 44229 3.9 ZBTB40 SIN3A NRF1 POLR2G PHF8 TEAD4 ZNF639 EP300 POLR2A ZBTB26 HELLS NONHSAG006566.2 ACSM6 NOC3L lnc-CYP2C18-2
GH10J093701 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -798.8 -798833 2.8 RXRA ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A TCF12 POLR2G USF1 FRA10AC1 lnc-PDE6C-6 PDE6C NOC3L RPL17P34 ENSG00000273450 MYOF HELLS
GH10J094401 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12 -97.9 -97896 4.1 ZNF217 SIN3A NRF1 POLR2G PHF8 ZFX ZIC2 POLR2A CLOCK ZNF423 TBC1D12 NOC3L HELLS PDE6C RF00017-749
GH10J094381 Enhancer 0.9 FANTOM5 Ensembl ENCODE 13.5 -118.4 -118433 4.4 FOS CEBPB SPI1 JUND POLR3A MYC ZNF680 PKNOX1 SOX13 HELLS PDE6C CYP2C19 NOC3L TBC1D12 PLCE1-AS1 RF00017-748
GH10J094397 Enhancer 0.8 Ensembl ENCODE 14.2 -103.4 -103433 1.6 TEAD1 ZEB1 OSR2 ZBTB17 BRCA1 JUND GLIS1 ZBTB33 NFIL3 TEAD3 HELLS TBC1D12 RF00017-748
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HELLS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HELLS

Top Transcription factor binding sites by QIAGEN in the HELLS gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • FOXF2
  • HOXA9
  • HOXA9B
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for HELLS Gene

Genomic Locations for HELLS Gene
chr10:94,501,434-94,613,905
(GRCh38/hg38)
Size:
112,472 bases
Orientation:
Plus strand
chr10:96,305,547-96,373,662
(GRCh37/hg19)
Size:
68,116 bases
Orientation:
Plus strand

Genomic View for HELLS Gene

Genes around HELLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HELLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HELLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELLS Gene

Proteins for HELLS Gene

  • Protein details for HELLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ9-HELLS_HUMAN
    Recommended name:
    Lymphoid-specific helicase
    Protein Accession:
    Q9NRZ9
    Secondary Accessions:
    • B2RB41
    • Q3LID1
    • Q6I7N7
    • Q76H76
    • Q76H77
    • Q76H78
    • Q76H79
    • Q76H80
    • Q76H81
    • Q7Z397
    • Q7Z5X2
    • Q8N6P4
    • Q9H4P5

    Protein attributes for HELLS Gene

    Size:
    838 amino acids
    Molecular mass:
    97074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG01987.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH30963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH31004.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HELLS Gene

neXtProt entry for HELLS Gene

Selected DME Specific Peptides for HELLS Gene

Q9NRZ9:
  • DEMGLGKT
  • LRRLKSDV
  • TGTPLQN
  • DSDWNPQ
  • AGGLGINL
  • RCHRIGQ
  • NGILADE
  • LLNFLLPD
  • GLGKTVQ

Post-translational modifications for HELLS Gene

  • Ubiquitination at Lys74, Lys80, Lys204, Lys731, and Lys753
  • Modification sites at PhosphoSitePlus

Domains & Families for HELLS Gene

Gene Families for HELLS Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HELLS Gene

Blocks:
  • SNF2 related domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HELLS Gene

GenScript: Design optimal peptide antigens:
  • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 (HELLS_HUMAN)
  • HELLS protein (Q0VGL2_HUMAN)
  • Lymphoid specific helicase variant9 (Q6I7N8_HUMAN)
  • cDNA FLJ10339 fis, clone NT2RM2000740, weakly similar to POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L (Q9NW36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRZ9

UniProtKB/Swiss-Prot:

HELLS_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with HELLS: view

Function for HELLS Gene

Molecular function for HELLS Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
UniProtKB/Swiss-Prot Induction:
By concanavalin-A in peripheral blood leukocytes.
GENATLAS Biochemistry:
helicase lymphoid specific,expressed in early thymocytes and testis,SNF2/RAD54 family potentially involved in DNA repair,homologous to S cerivisiae YFK8

Enzyme Numbers (IUBMB) for HELLS Gene

Phenotypes From GWAS Catalog for HELLS Gene

Gene Ontology (GO) - Molecular Function for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 22157815
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HELLS: view
genes like me logo Genes that share phenotypes with HELLS: view

Human Phenotype Ontology for HELLS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HELLS Gene

MGI Knock Outs for HELLS:
  • Hells Hells<tm1Rarc>
  • Hells Hells<tm1a(EUCOMM)Wtsi>
  • Hells Hells<tm1Kmu>
  • Hells Hells<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for HELLS

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for HELLS Gene

Localization for HELLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELLS Gene

Nucleus. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HELLS gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region ISS --
GO:0005634 nucleus IEA --
GO:0005721 pericentric heterochromatin ISS --
genes like me logo Genes that share ontologies with HELLS: view

Pathways & Interactions for HELLS Gene

PathCards logo

SuperPathways for HELLS Gene

SuperPathway Contained pathways
1 AMPK Enzyme Complex Pathway
.01
-
2 Chromatin Regulation / Acetylation
3 BRCA1 Pathway
-
4 PEDF Induced Signaling
.43
5 Apoptosis Modulation and Signaling
.41
genes like me logo Genes that share pathways with HELLS: view

Pathways by source for HELLS Gene

4 Qiagen pathways for HELLS Gene
  • AMPK Enzyme Complex Pathway
  • BRCA1 Pathway
  • Chromatin Remodeling
  • Glucocorticoid Receptor Signaling
1 Cell Signaling Technology pathway for HELLS Gene

Gene Ontology (GO) - Biological Process for HELLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0006306 DNA methylation IEA --
GO:0006342 chromatin silencing IEA --
GO:0006346 methylation-dependent chromatin silencing ISS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with HELLS: view

No data available for SIGNOR curated interactions for HELLS Gene

Drugs & Compounds for HELLS Gene

(29) Drugs for HELLS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(27) Additional Compounds for HELLS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HELLS: view

Transcripts for HELLS Gene

mRNA/cDNA for HELLS Gene

10 REFSEQ mRNAs :
28 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELLS Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: -
SP2:
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - - -
SP7: -
SP8:
SP9:

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for HELLS Gene

GeneLoc Exon Structure for
HELLS

Expression for HELLS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HELLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HELLS Gene

This gene is overexpressed in Breast (41.0) and Tlymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HELLS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HELLS

SOURCE GeneReport for Unigene cluster for HELLS Gene:

Hs.655830

mRNA Expression by UniProt/SwissProt for HELLS Gene:

Q9NRZ9-HELLS_HUMAN
Tissue specificity: Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.

Evidence on tissue expression from TISSUES for HELLS Gene

  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HELLS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • sinus
  • skull
  • tongue
Thorax:
  • bronchus
  • lung
Abdomen:
  • intestine
  • large intestine
  • small intestine
General:
  • blood
  • bone marrow
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with HELLS: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for HELLS Gene

Orthologs for HELLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HELLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HELLS 31 30
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HELLS 31 30
  • 92.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HELLS 31 30
  • 91.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hells 17 31 30
  • 89.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HELLS 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HELLS 31
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves HELLS 31
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HELLS 31
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hells 31
  • 64 (a)
OneToOne
sbcb65 30
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04159g 30
  • 54.42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRC5 33 31 30
  • 53.68 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL098C 30
  • 52.36 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.23819 30
barley
(Hordeum vulgare)
Liliopsida Hv.2667 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToMany
CSA.5063 31
  • 48 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
Species where no ortholog for HELLS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for HELLS Gene

ENSEMBL:
Gene Tree for HELLS (if available)
TreeFam:
Gene Tree for HELLS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HELLS: view image

Paralogs for HELLS Gene

(24) SIMAP similar genes for HELLS Gene using alignment to 6 proteins:

  • HELLS_HUMAN
  • B1ALG6_HUMAN
  • Q0VGL2_HUMAN
  • Q6I7N8_HUMAN
  • Q76H82_HUMAN
  • Q9NW36_HUMAN
genes like me logo Genes that share paralogs with HELLS: view

Variants for HELLS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HELLS Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
708084 Benign: not provided 94,588,396(+) G/A INTRON_VARIANT
708367 Benign: not provided 94,592,514(+) C/T SYNONYMOUS_VARIANT
709251 Benign: not provided 94,592,508(+) A/G SYNONYMOUS_VARIANT
710853 Benign: not provided 94,576,766(+) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
716400 Benign: not provided 94,545,923(+) T/C INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for HELLS Gene

Structural Variations from Database of Genomic Variants (DGV) for HELLS Gene

Variant ID Type Subtype PubMed ID
esv3546703 CNV deletion 23714750
nsv517681 CNV gain 19592680

Variation tolerance for HELLS Gene

Residual Variation Intolerance Score: 7.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HELLS Gene

Human Gene Mutation Database (HGMD)
HELLS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HELLS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELLS Gene

Disorders for HELLS Gene

MalaCards: The human disease database

(19) MalaCards diseases for HELLS Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HELLS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HELLS_HUMAN
  • Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4) [MIM:616911]: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. {ECO:0000269 PubMed:26216346}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HELLS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HELLS: view

No data available for Genatlas for HELLS Gene

Publications for HELLS Gene

  1. Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. (PMID: 10910076) Lee DW … Arceci RJ (Cancer research 2000) 2 3 4 23 54
  2. Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh). (PMID: 9878251) Geiman TM … Muegge K (Genomics 1998) 2 3 23 54
  3. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. (PMID: 26216346) Thijssen PE … Sasaki H (Nature communications 2015) 3 4 54
  4. Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. (PMID: 19561196) Zhou R … Tong T (Nucleic acids research 2009) 3 23 54
  5. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri RT … Australian Ovarian Cancer Study Group (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 41 54

Products for HELLS Gene

Sources for HELLS Gene