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HECTD4 (HECT Domain E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. Diseases associated with HECTD4 include Plantar Fasciitis and Heel Spur. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is HUWE1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 15161933 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006006 | glucose metabolic process | IMP | 23575436 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0042593 | glucose homeostasis | IMP | 23575436 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||
SP2: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HECTD4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
HECTD4 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | HECTD4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HECTD4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gm15800 30 31 |
|
OneToOne | |
Hectd4 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | RGD1309762 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HECTD4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HECTD4 31 |
|
OneToOne | |
C15H12orf51 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | HECTD4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hectd4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CU459012.3 31 |
|
OneToMany | |
HECTD4 (1 of 3) 31 |
|
OneToMany | |||
HECTD4 (3 of 3) 31 |
|
OneToMany | |||
LOC101885095 30 |
|
||||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOM1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714185 | Benign: not provided | 112,167,443(-) | G/A | SYNONYMOUS_VARIANT | |
714186 | Benign: not provided | 112,216,859(-) | T/G | SYNONYMOUS_VARIANT | |
773266 | Benign: not provided | 112,163,079(-) | C/T | SYNONYMOUS_VARIANT | |
787932 | Benign: not provided | 112,167,392(-) | G/A | SYNONYMOUS_VARIANT | |
787933 | Benign: not provided | 112,216,356(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv305e214 | CNV | gain | 21293372 |
esv1004944 | CNV | deletion | 20482838 |
esv1916833 | CNV | deletion | 18987734 |
esv2746362 | CNV | deletion | 23290073 |
esv2746365 | CNV | deletion | 23290073 |
esv2746366 | CNV | deletion | 23290073 |
esv2746367 | CNV | deletion | 23290073 |
esv2746368 | CNV | deletion | 23290073 |
esv3349536 | CNV | insertion | 20981092 |
esv4498 | CNV | loss | 18987735 |
nsv1122765 | CNV | deletion | 24896259 |
nsv1126321 | CNV | deletion | 24896259 |
nsv1142815 | CNV | tandem duplication | 24896259 |
nsv1148350 | CNV | insertion | 26484159 |
nsv470318 | CNV | gain | 18288195 |
nsv476648 | CNV | novel sequence insertion | 20440878 |
nsv483114 | CNV | gain | 15286789 |
nsv975530 | CNV | duplication | 23825009 |
nsv983364 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
plantar fasciitis |
|
|
heel spur |
|
|
tibial neuropathy |
|
|
tarsal tunnel syndrome |
|
|
achilles bursitis |
|
|