The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012] See more...

Aliases for HECTD3 Gene

Aliases for HECTD3 Gene

  • HECT Domain E3 Ubiquitin Protein Ligase 3 2 3 5
  • HECT Domain Containing E3 Ubiquitin Protein Ligase 3 2 3
  • HECT-Type E3 Ubiquitin Transferase HECTD3 3 4
  • E3 Ubiquitin-Protein Ligase HECTD3 3 4
  • HECT Domain-Containing Protein 3 4
  • EC 2.3.2.26 4
  • FLJ21156 2
  • HECTD3 5

External Ids for HECTD3 Gene

Previous GeneCards Identifiers for HECTD3 Gene

  • GC01M045138
  • GC01M045240
  • GC01M045468
  • GC01M043580

Summaries for HECTD3 Gene

Entrez Gene Summary for HECTD3 Gene

  • The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

GeneCards Summary for HECTD3 Gene

HECTD3 (HECT Domain E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and syntaxin binding.

UniProtKB/Swiss-Prot Summary for HECTD3 Gene

  • E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

Additional gene information for HECTD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HECTD3 Gene

Genomics for HECTD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HECTD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HECTD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HECTD3

Top Transcription factor binding sites by QIAGEN in the HECTD3 gene promoter:
  • AhR
  • Arnt
  • Brachyury
  • CUTL1
  • E47
  • Nkx2-5
  • Pbx1a
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for HECTD3 Gene

Genomic Locations for HECTD3 Gene
chr1:45,002,540-45,011,324
(GRCh38/hg38)
Size:
8,785 bases
Orientation:
Minus strand
chr1:45,468,212-45,477,027
(GRCh37/hg19)
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for HECTD3 Gene

Genes around HECTD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECTD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECTD3 Gene

Proteins for HECTD3 Gene

  • Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T447-HECD3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HECTD3
    Protein Accession:
    Q5T447
    Secondary Accessions:
    • B3KPV7
    • B3KRH4
    • Q5T448
    • Q9H783

    Protein attributes for HECTD3 Gene

    Size:
    861 amino acids
    Molecular mass:
    97113 Da
    Quaternary structure:
    • Interacts with TRIOBP. Interacts with STX8 (By similarity).
    SequenceCaution:
    • Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for HECTD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HECTD3 Gene

Post-translational modifications for HECTD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECTD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECTD3 Gene

Domains & Families for HECTD3 Gene

Gene Families for HECTD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HECTD3 Gene

InterPro:
Blocks:
  • HECT domain (Ubiquitin-protein ligase)
ProtoNet:

Suggested Antigen Peptide Sequences for HECTD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31983 fis, clone NT2RP7008557, highly similar to Probable E3 ubiquitin-protein ligase HECTD3 (A1A4G1_HUMAN)
  • HECT domain-containing protein 3 (HECD3_HUMAN)
genes like me logo Genes that share domains with HECTD3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HECTD3 Gene

Function for HECTD3 Gene

Molecular function for HECTD3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26;.

Enzyme Numbers (IUBMB) for HECTD3 Gene

Phenotypes From GWAS Catalog for HECTD3 Gene

Gene Ontology (GO) - Molecular Function for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 18194665
GO:0016740 transferase activity IEA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with HECTD3: view
genes like me logo Genes that share phenotypes with HECTD3: view

Animal Models for HECTD3 Gene

MGI Knock Outs for HECTD3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HECTD3

CRISPR Products

miRNA for HECTD3 Gene

miRTarBase miRNAs that target HECTD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECTD3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD3 Gene

Localization for HECTD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HECTD3 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with HECTD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HECTD3 Gene

Pathways & Interactions for HECTD3 Gene

genes like me logo Genes that share pathways with HECTD3: view

UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HECTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 18194665
genes like me logo Genes that share ontologies with HECTD3: view

No data available for SIGNOR curated interactions for HECTD3 Gene

Drugs & Compounds for HECTD3 Gene

No Compound Related Data Available

Transcripts for HECTD3 Gene

mRNA/cDNA for HECTD3 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECTD3

Alternative Splicing Database (ASD) splice patterns (SP) for HECTD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for HECTD3 Gene

GeneLoc Exon Structure for
HECTD3

Expression for HECTD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HECTD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HECTD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HECTD3 Gene



Protein tissue co-expression partners for HECTD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HECTD3

SOURCE GeneReport for Unigene cluster for HECTD3 Gene:

Hs.525084

Evidence on tissue expression from TISSUES for HECTD3 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with HECTD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECTD3 Gene

Orthologs for HECTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HECTD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HECTD3 30 31
  • 99.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HECTD3 30 31
  • 92.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HECTD3 30 31
  • 92.14 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HECTD3 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Hectd3 30 17 31
  • 90.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hectd3 30
  • 88.02 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 3 (a)
OneToMany
-- 31
  • 1 (a)
OneToMany
-- 31
  • 1 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 80 (a)
OneToMany
HECTD3 30
  • 76.17 (n)
-- 31
  • 68 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia HECTD3 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hectd3 30
  • 66.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16865 30
Zebrafish
(Danio rerio)
Actinopterygii hectd3 30 31
  • 67.1 (n)
OneToOne
Dr.4430 30
Fruit Fly
(Drosophila melanogaster)
Insecta HERC2 31
  • 4 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8388 31
  • 5 (a)
ManyToMany
Species where no ortholog for HECTD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HECTD3 Gene

ENSEMBL:
Gene Tree for HECTD3 (if available)
TreeFam:
Gene Tree for HECTD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HECTD3: view image

Paralogs for HECTD3 Gene

No data available for Paralogs for HECTD3 Gene

Variants for HECTD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HECTD3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711828 Benign: not provided 45,006,112(-) T/C MISSENSE_VARIANT
711829 Benign: not provided 45,006,731(-) G/A SYNONYMOUS_VARIANT
757624 Likely Benign: not provided 45,003,724(-) C/T MISSENSE_VARIANT
757625 Likely Benign: not provided 45,007,461(-) A/C SYNONYMOUS_VARIANT
777749 Benign: not provided 45,010,209(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HECTD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HECTD3 Gene

Variant ID Type Subtype PubMed ID
nsv950706 CNV deletion 24416366

Variation tolerance for HECTD3 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HECTD3 Gene

Human Gene Mutation Database (HGMD)
HECTD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HECTD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD3 Gene

Disorders for HECTD3 Gene

No disorders were found for HECTD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD3 Gene

Publications for HECTD3 Gene

  1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J … Huang H (Biochemical and biophysical research communications 2008) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for HECTD3 Gene

Sources for HECTD3 Gene