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The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012] See more...
Aliases for HECTD3 Gene
Aliases for HECTD3 Gene
External Ids for HECTD3 Gene
- HGNC: 26117
- Entrez Gene: 79654
- Ensembl: ENSG00000126107
- OMIM: 618638
- UniProtKB: Q5T447
Previous GeneCards Identifiers for HECTD3 Gene
- GC01M045138
- GC01M045240
- GC01M045468
- GC01M043580
Summaries for HECTD3 Gene
-
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
GeneCards Summary for HECTD3 Gene
HECTD3 (HECT Domain E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and syntaxin binding.
UniProtKB/Swiss-Prot Summary for HECTD3 Gene
-
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
Additional gene information for HECTD3 Gene
- HGNC(26117)
- Entrez Gene(79654)
- Ensembl(ENSG00000126107)
- OMIM(618638)
- UniProtKB(Q5T447)
- Open Targets Platform(ENSG00000126107)
- Search for HECTD3 at DataMed
- Search for HECTD3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HECTD3 Gene
Genomics for HECTD3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HECTD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HECTD3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HECTD3
- Top Transcription factor binding sites by QIAGEN in the HECTD3 gene promoter:
-
- AhR
- Arnt
- Brachyury
- CUTL1
- E47
- Nkx2-5
- Pbx1a
- Tal-1beta
- USF-1
- USF1
Genomic Locations for HECTD3 Gene
Genomic Locations for HECTD3 Gene
- chr1:45,002,540-45,011,324
- (GRCh38/hg38)
- Size:
- 8,785 bases
- Orientation:
- Minus strand
- chr1:45,468,212-45,477,027
- (GRCh37/hg19)
- Size:
- 8,816 bases
- Orientation:
- Minus strand
Genomic View for HECTD3 Gene
Genes around HECTD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by HGNC
- 1p34.1 by Entrez Gene
- 1p34.1 by Ensembl
HECTD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HECTD3 Gene
Proteins for HECTD3 Gene
-
Protein details for HECTD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T447-HECD3_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase HECTD3
- Protein Accession:
- Q5T447
- B3KPV7
- B3KRH4
- Q5T448
- Q9H783
Protein attributes for HECTD3 Gene
- Size:
- 861 amino acids
- Molecular mass:
- 97113 Da
- Quaternary structure:
-
- Interacts with TRIOBP. Interacts with STX8 (By similarity).
- SequenceCaution:
-
- Sequence=BAB15015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
Protein Expression for HECTD3 Gene
Post-translational modifications for HECTD3 Gene
Other Protein References for HECTD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents HECTD3 Antibody
- Creative Diagnostics Anti-HECTD3 monoclonal antibody
- Novus Biologicals Antibodies for HECTD3
-
Abcam antibodies for HECTD3
- Invitrogen Antibodies for HECTD3 (AFLGC-HECTD3)
-
Boster Bio Antibodies for HECTD3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HECTD3
- Origene Custom Protein Services for HECTD3
- antibodies-online: Show 4 available HECTD3 Proteins ranked by validation data
- Compare Top HECTD3 Proteins
-
Quality Products:
-
Abcam proteins for HECTD3
No data available for DME Specific Peptides for HECTD3 Gene
Domains & Families for HECTD3 Gene
Gene Families for HECTD3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for HECTD3 Gene
- InterPro:
- Blocks:
-
- HECT domain (Ubiquitin-protein ligase)
- ProtoNet:
Suggested Antigen Peptide Sequences for HECTD3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ31983 fis, clone NT2RP7008557, highly similar to Probable E3 ubiquitin-protein ligase HECTD3 (A1A4G1_HUMAN)
- HECT domain-containing protein 3 (HECD3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HECTD3 Gene
Function for HECTD3 Gene
Molecular function for HECTD3 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26;.
Enzyme Numbers (IUBMB) for HECTD3 Gene
Phenotypes From GWAS Catalog for HECTD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 18194665 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019905 | syntaxin binding | IEA | -- |
Phenotypes for HECTD3 Gene
- MGI mutant phenotypes for HECTD3:
-
inferred from 2 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for HECTD3:
Animal Models for HECTD3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for HECTD3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HECTD3 - Select products 50% OFF >
- * HECTD3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HECTD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HECTD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD3
miRNA for HECTD3 Gene
- miRTarBase miRNAs that target HECTD3
-
- hsa-miR-122-5p (MIRT023327)
- hsa-miR-7-5p (MIRT025780)
- hsa-miR-26b-5p (MIRT029557)
- hsa-miR-615-3p (MIRT039878)
- hsa-miR-484 (MIRT041762)
- hsa-miR-4755-3p (MIRT138483)
- hsa-miR-4459 (MIRT455926)
- hsa-miR-486-3p (MIRT455927)
- hsa-miR-6721-5p (MIRT455928)
- hsa-miR-4722-5p (MIRT455929)
- hsa-miR-6087 (MIRT455930)
- hsa-miR-219a-2-3p (MIRT455931)
- hsa-miR-1247-3p (MIRT455932)
- hsa-miR-4768-3p (MIRT455933)
- mmu-miR-331-3p (MIRT595992)
- mmu-miR-199a-3p (MIRT595993)
- mmu-miR-199b-3p (MIRT595994)
- hsa-miR-6513-5p (MIRT667966)
- hsa-miR-887-5p (MIRT667967)
- hsa-miR-3913-5p (MIRT667968)
- hsa-miR-3122 (MIRT667969)
- hsa-miR-450a-1-3p (MIRT667970)
- hsa-miR-6780a-5p (MIRT667971)
- hsa-miR-6779-5p (MIRT667972)
- hsa-miR-3689c (MIRT667973)
- hsa-miR-3689b-3p (MIRT667974)
- hsa-miR-3689a-3p (MIRT667975)
- hsa-miR-30b-3p (MIRT667976)
- hsa-miR-1273h-5p (MIRT667977)
- hsa-miR-6788-5p (MIRT667978)
- hsa-miR-30c-2-3p (MIRT667979)
- hsa-miR-30c-1-3p (MIRT667980)
- hsa-miR-7977 (MIRT667981)
- hsa-miR-6799-5p (MIRT667982)
- hsa-miR-6883-5p (MIRT667983)
- hsa-miR-6785-5p (MIRT667984)
- hsa-miR-4728-5p (MIRT667985)
- hsa-miR-149-3p (MIRT667986)
- hsa-miR-7106-5p (MIRT667987)
- hsa-miR-3166 (MIRT667988)
- hsa-miR-383-3p (MIRT667989)
- hsa-miR-1288-5p (MIRT667990)
- hsa-miR-1324 (MIRT667991)
- hsa-miR-6511a-5p (MIRT667992)
- hsa-miR-1910-3p (MIRT667993)
- hsa-miR-3714 (MIRT667994)
- hsa-miR-6514-3p (MIRT674623)
- hsa-miR-24-3p (MIRT674624)
- hsa-miR-4284 (MIRT674625)
- hsa-miR-6847-3p (MIRT674626)
- hsa-miR-6811-3p (MIRT674627)
- hsa-miR-214-5p (MIRT674628)
- hsa-miR-5693 (MIRT674629)
- hsa-miR-26a-5p (MIRT727508)
- hsa-miR-153-3p (MIRT733611)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HECTD3
- Browse OriGene Inhibitory RNA Products For HECTD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECTD3
Clone Products
- Applied Biological Materials (abm): Clones for HECTD3 - Select products 50% OFF >
- * HECTD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HECTD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HECTD3
Cell Line Products
-
Horizon Cell Lines for HECTD3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HECTD3 Gene
Localization for HECTD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HECTD3 Gene
- Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HECTD3 Gene
Pathways & Interactions for HECTD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for HECTD3 Gene
4 Reactome pathways for HECTD3 Gene
UniProtKB/Swiss-Prot Q5T447-HECD3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for HECTD3 Gene
Selected Interacting proteins:
ENSP00000361245
Q5T447-HECD3_HUMAN
for HECTD3 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for HECTD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | 18194665 |
No data available for SIGNOR curated interactions for HECTD3 Gene
Transcripts for HECTD3 Gene
mRNA/cDNA for HECTD3 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000372168 2530 nts (view in UCSC)
- ENST00000372172 3597 nts (view in UCSC)
- ENST00000466423 914 nts (view in UCSC)
- ENST00000484564 314 nts (view in UCSC)
- ENST00000486132 2385 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HECTD3 - Select products 50% OFF >
- * HECTD3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HECTD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HECTD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HECTD3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HECTD3
- Browse OriGene Inhibitory RNA Products For HECTD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECTD3
Clone Products
- Applied Biological Materials (abm): Clones for HECTD3 - Select products 50% OFF >
- * HECTD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HECTD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HECTD3
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: |
Relevant External Links for HECTD3 Gene
- GeneLoc Exon Structure for
- HECTD3
Expression for HECTD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HECTD3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HECTD3
SOURCE GeneReport for Unigene cluster for HECTD3 Gene:
Hs.525084Evidence on tissue expression from TISSUES for HECTD3 Gene
- Nervous system(4.8)
- Muscle(4.3)
Primer Products
-
OriGene qPCR primer pairs for HECTD3
-
OriGene qPCR primer pairs and template standards for HECTD3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECTD3 Gene
Orthologs for HECTD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HECTD3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HECTD3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HECTD3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HECTD3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hectd3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hectd3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| HECTD3 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | HECTD3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hectd3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16865 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hectd3 30 31 |
|
OneToOne | |
| Dr.4430 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | HERC2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8388 31 |
|
ManyToMany |
- Species where no ortholog for HECTD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HECTD3 Gene
- ENSEMBL:
- Gene Tree for HECTD3 (if available)
- TreeFam:
- Gene Tree for HECTD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HECTD3: view image
Paralogs for HECTD3 Gene
No data available for Paralogs for HECTD3 Gene
Variants for HECTD3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HECTD3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711828 | Benign: not provided | 45,006,112(-) | T/C | MISSENSE_VARIANT | |
| 711829 | Benign: not provided | 45,006,731(-) | G/A | SYNONYMOUS_VARIANT | |
| 757624 | Likely Benign: not provided | 45,003,724(-) | C/T | MISSENSE_VARIANT | |
| 757625 | Likely Benign: not provided | 45,007,461(-) | A/C | SYNONYMOUS_VARIANT | |
| 777749 | Benign: not provided | 45,010,209(-) | T/C | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.62;
72.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HECTD3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECTD3 Gene
Disorders for HECTD3 Gene
Additional Disease Information for HECTD3
No disorders were found for HECTD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HECTD3 Gene
Publications for HECTD3 Gene
- The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PMID: 18194665) Yu J … Huang H (Biochemical and biophysical research communications 2008) 2 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for HECTD3 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HECTD3
- Origene Custom Protein Services for HECTD3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HECTD3
- Browse OriGene Inhibitory RNA Products For HECTD3
- OriGene qPCR primer pairs for HECTD3
- OriGene qPCR primer pairs and template standards for HECTD3
- OriGene CRISPR knockouts for HECTD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HECTD3
- Sino Biological Human cDNA Clone for HECTD3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HECTD3
- Novus Biologicals proteins and lysates for HECTD3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HECTD3
- Abcam proteins for HECTD3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Taconic Biosciences Mouse Models for HECTD3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for HECTD3 (AFLGC-HECTD3)
- VectorBuilder Custom and pre-made DNA vectors for HECTD3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HECTD3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HECTD3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HECTD3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HECTD3
- antibodies-online: Show 10 available HECTD3 Antibodies ranked by validation data
- Compare Top HECTD3 Antibodies
- antibodies-online: Search results for available HECTD3 related products ranked by validation data
- antibodies-online: Show 4 available HECTD3 Proteins ranked by validation data
- Compare Top HECTD3 Proteins
- Quality Products:
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HECTD3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HECTD3
- Horizon Cell Lines for HECTD3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HECTD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HECTD3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HECTD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECTD3
- Boster Bio Antibodies for HECTD3
- Browse Boster Bio ELISA Kits
Sources for HECTD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB