This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008] See more...

Aliases for HECA Gene

Aliases for HECA Gene

  • Hdc Homolog, Cell Cycle Regulator 2 3 5
  • HHDC 2 3 4
  • HDC 2 3 4
  • Headcase Protein Homolog 3 4
  • DJ225E12.1 2 3
  • HDCL 2 3
  • Headcase Homolog (Drosophila) 2
  • Headcase Homolog 3
  • HECA 5

External Ids for HECA Gene

Previous GeneCards Identifiers for HECA Gene

  • GC06P139391
  • GC06P139436
  • GC06P139497
  • GC06P137017

Summaries for HECA Gene

Entrez Gene Summary for HECA Gene

  • This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]

GeneCards Summary for HECA Gene

HECA (Hdc Homolog, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HECA include Lichen Nitidus and Venous Hemangioma.

UniProtKB/Swiss-Prot Summary for HECA Gene

  • May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HECA Gene

Genomics for HECA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HECA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HECA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HECA

Top Transcription factor binding sites by QIAGEN in the HECA gene promoter:
  • CREB
  • ISGF-3
  • MyoD
  • NRSF form 1
  • NRSF form 2
  • Pax-3
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for HECA Gene

Genomic Locations for HECA Gene
chr6:139,135,080-139,180,802
(GRCh38/hg38)
Size:
45,723 bases
Orientation:
Plus strand
chr6:139,456,249-139,501,946
(GRCh37/hg19)
Size:
45,698 bases
Orientation:
Plus strand

Genomic View for HECA Gene

Genes around HECA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECA Gene

Proteins for HECA Gene

  • Protein details for HECA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI9-HDC_HUMAN
    Recommended name:
    Headcase protein homolog
    Protein Accession:
    Q9UBI9

    Protein attributes for HECA Gene

    Size:
    543 amino acids
    Molecular mass:
    58837 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HECA Gene

Post-translational modifications for HECA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HECA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECA Gene

Domains & Families for HECA Gene

Gene Families for HECA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HECA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HECA Gene

GenScript: Design optimal peptide antigens:
  • Headcase protein homolog (HDC_HUMAN)
genes like me logo Genes that share domains with HECA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HECA Gene

Function for HECA Gene

Molecular function for HECA Gene

UniProtKB/Swiss-Prot Function:
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

Phenotypes From GWAS Catalog for HECA Gene

Gene Ontology (GO) - Molecular Function for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HECA: view
genes like me logo Genes that share phenotypes with HECA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECA Gene

Localization for HECA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HECA gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19643820
GO:0005737 cytoplasm IDA 19643820
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HECA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for HECA Gene

Pathways & Interactions for HECA Gene

PathCards logo

SuperPathways for HECA Gene

No Data Available

Gene Ontology (GO) - Biological Process for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030323 respiratory tube development NAS 11696983
GO:0045930 negative regulation of mitotic cell cycle IMP 22100912
genes like me logo Genes that share ontologies with HECA: view

No data available for Pathways by source and SIGNOR curated interactions for HECA Gene

Drugs & Compounds for HECA Gene

(1) Drugs for HECA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HECA: view

Transcripts for HECA Gene

mRNA/cDNA for HECA Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HECA

Alternative Splicing Database (ASD) splice patterns (SP) for HECA Gene

No ASD Table

Relevant External Links for HECA Gene

GeneLoc Exon Structure for
HECA

Expression for HECA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HECA Gene

Protein differential expression in normal tissues from HIPED for HECA Gene

This gene is overexpressed in Fetal Brain (17.1), CD4 Tcells (13.3), Frontal cortex (8.5), Blymphocyte (7.7), CD8 Tcells (7.3), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HECA Gene



Protein tissue co-expression partners for HECA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HECA

SOURCE GeneReport for Unigene cluster for HECA Gene:

Hs.197644

mRNA Expression by UniProt/SwissProt for HECA Gene:

Q9UBI9-HDC_HUMAN
Tissue specificity: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.

Evidence on tissue expression from TISSUES for HECA Gene

  • Blood(2.8)
  • Heart(2.6)
  • Lymph node(2.5)
  • Spleen(2.5)
  • Skin(2.5)
  • Intestine(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with HECA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECA Gene

Orthologs for HECA Gene

This gene was present in the common ancestor of animals.

Orthologs for HECA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HECA 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HECA 30 31
  • 89.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HECA 30 31
  • 89.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Heca 30
  • 89.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia HECA 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Heca 30 17 31
  • 87.91 (n)
OneToOne
Chicken
(Gallus gallus)
Aves HECA 30 31
  • 81.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HECA 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia heca 30
  • 71.9 (n)
Str.19505 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.31027 30
Zebrafish
(Danio rerio)
Actinopterygii heca 30 31
  • 75.41 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta hdc 31
  • 25 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cri-1 31
  • 27 (a)
OneToMany
B0238.9 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Species where no ortholog for HECA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HECA Gene

ENSEMBL:
Gene Tree for HECA (if available)
TreeFam:
Gene Tree for HECA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HECA: view image

Paralogs for HECA Gene

No data available for Paralogs for HECA Gene

Variants for HECA Gene

Additional dbSNP identifiers (rs#s) for HECA Gene

Structural Variations from Database of Genomic Variants (DGV) for HECA Gene

Variant ID Type Subtype PubMed ID
esv32697 CNV gain 17666407
esv3610966 CNV gain 21293372

Variation tolerance for HECA Gene

Residual Variation Intolerance Score: 6.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HECA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HECA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HECA Gene

Disorders for HECA Gene

MalaCards: The human disease database

(3) MalaCards diseases for HECA Gene - From: DISEASES

Disorder Aliases PubMed IDs
lichen nitidus
  • pinkus' disease
venous hemangioma
parapsoriasis
  • digitate dermatosis
- elite association - COSMIC cancer census association via MalaCards
Search HECA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HECA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HECA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HECA Gene

Publications for HECA Gene

  1. Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (PMID: 11696983) Makino N … Horii A (DNA sequence : the journal of DNA sequencing and mapping 2001) 2 3 4 23
  2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. (PMID: 19643820) Dowejko A … Reichert TE (Carcinogenesis 2009) 2 3 23
  3. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. (PMID: 22100912) Dowejko A … Reichert TE (Experimental cell research 2012) 2 3
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  5. A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. (PMID: 16525680) Chien CC … Huang CJ (Oncology reports 2006) 3 23

Products for HECA Gene

Sources for HECA Gene