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Aliases for HECA Gene

Aliases for HECA Gene

  • Hdc Homolog, Cell Cycle Regulator 2 3 5
  • HHDC 3 4
  • HDC 3 4
  • Headcase Homolog (Drosophila) 2
  • Headcase Protein Homolog 3
  • Headcase Homolog 3
  • DJ225E12.1 3
  • HDCL 3

External Ids for HECA Gene

Previous GeneCards Identifiers for HECA Gene

  • GC06P139391
  • GC06P139436
  • GC06P139497
  • GC06P137017

Summaries for HECA Gene

Entrez Gene Summary for HECA Gene

  • This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]

GeneCards Summary for HECA Gene

HECA (Hdc Homolog, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HECA include Lichen Nitidus.

UniProtKB/Swiss-Prot for HECA Gene

  • May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

Additional gene information for HECA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HECA Gene

Genomics for HECA Gene

GeneHancer (GH) Regulatory Elements for HECA Gene

Promoters and enhancers for HECA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I139131 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 556.7 -0.5 -540 5.9 PKNOX1 ARNT ARID4B SIN3A E2F8 ZNF207 ZNF143 FOS KLF13 SP3 HECA ABRACL TXLNB ECT2L GC06P139052
GH06I139289 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.5 +156.6 156580 4.7 HDGF PKNOX1 ZNF133 FEZF1 ZNF2 IRF4 ATF7 ZNF548 FOS RUNX3 TXLNB LOC102723690 CITED2 HECA REPS1 ABRACL ENSG00000272446
GH06I139111 Enhancer 1 FANTOM5 ENCODE dbSUPER 17.7 -21.8 -21784 3.6 OSR2 GATA3 ZSCAN4 FOXP2 SP7 HECA ECT2L LOC102723690 ABRACL REPS1 GC06P139052
GH06I139027 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 6.5 -106.0 -105957 3.7 HDGF FOXA2 SMAD1 ARNT SIN3A ZNF2 YY1 KLF13 SP3 JUNB ABRACL GC06M139027 HECA CCDC28A GC06P139052
GH06I139364 Enhancer 1 Ensembl ENCODE dbSUPER 10.8 +229.4 229415 0.3 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST ELF1 RAD21 GABPA ZNF213 ENSG00000231329 LOC102723690 HECA CITED2 LOC100129844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HECA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HECA gene promoter:

Genomic Locations for HECA Gene

Genomic Locations for HECA Gene
45,698 bases
Plus strand

Genomic View for HECA Gene

Genes around HECA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HECA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HECA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HECA Gene

Proteins for HECA Gene

  • Protein details for HECA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Headcase protein homolog
    Protein Accession:

    Protein attributes for HECA Gene

    543 amino acids
    Molecular mass:
    58837 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HECA Gene

Post-translational modifications for HECA Gene

No Post-translational modifications

Other Protein References for HECA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HECA Gene

Domains & Families for HECA Gene

Gene Families for HECA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HECA Gene


Suggested Antigen Peptide Sequences for HECA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HECA: view

No data available for UniProtKB/Swiss-Prot for HECA Gene

Function for HECA Gene

Molecular function for HECA Gene

UniProtKB/Swiss-Prot Function:
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.

Phenotypes From GWAS Catalog for HECA Gene

Gene Ontology (GO) - Molecular Function for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HECA: view
genes like me logo Genes that share phenotypes with HECA: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HECA Gene

Localization for HECA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HECA gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19643820
GO:0005737 cytoplasm IDA 19643820
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with HECA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for HECA Gene

Pathways & Interactions for HECA Gene

No Data Available

Interacting Proteins for HECA Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q9UBI9-HDC_HUMAN ENSP00000356630 for HECA Gene via IID STRING

Gene Ontology (GO) - Biological Process for HECA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030323 respiratory tube development NAS 11696983
GO:0045930 negative regulation of mitotic cell cycle IMP 22100912
genes like me logo Genes that share ontologies with HECA: view

No data available for Pathways by source and SIGNOR curated interactions for HECA Gene

Drugs & Compounds for HECA Gene

(1) Drugs for HECA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HECA: view

Transcripts for HECA Gene

mRNA/cDNA for HECA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(128) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HECA Gene

Headcase homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HECA Gene

No ASD Table

Relevant External Links for HECA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HECA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HECA Gene

Protein differential expression in normal tissues from HIPED for HECA Gene

This gene is overexpressed in Fetal Brain (17.1), CD4 Tcells (13.3), Frontal cortex (8.5), Blymphocyte (7.7), CD8 Tcells (7.3), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HECA Gene

Protein tissue co-expression partners for HECA Gene

NURSA nuclear receptor signaling pathways regulating expression of HECA Gene:


SOURCE GeneReport for Unigene cluster for HECA Gene:


mRNA Expression by UniProt/SwissProt for HECA Gene:

Tissue specificity: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.

Evidence on tissue expression from TISSUES for HECA Gene

  • Skin(2.5)
  • Blood(2.4)
  • Heart(2.3)
  • Lymph node(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with HECA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HECA Gene

Orthologs for HECA Gene

This gene was present in the common ancestor of animals.

Orthologs for HECA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HECA 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia HECA 33 34
  • 89.67 (n)
(Bos Taurus)
Mammalia HECA 33 34
  • 89.3 (n)
(Rattus norvegicus)
Mammalia Heca 33
  • 89.08 (n)
(Monodelphis domestica)
Mammalia HECA 34
  • 88 (a)
(Mus musculus)
Mammalia Heca 33 16 34
  • 87.91 (n)
(Gallus gallus)
Aves HECA 33 34
  • 81.39 (n)
(Anolis carolinensis)
Reptilia HECA 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia heca 33
  • 71.9 (n)
Str.19505 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.31027 33
(Danio rerio)
Actinopterygii heca 33 34
  • 75.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta hdc 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea cri-1 34
  • 27 (a)
B0238.9 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for HECA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HECA Gene

Gene Tree for HECA (if available)
Gene Tree for HECA (if available)

Paralogs for HECA Gene

No data available for Paralogs for HECA Gene

Variants for HECA Gene

Sequence variations from dbSNP and Humsavar for HECA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000040893 -- 139,170,304(+) C/G/T intron_variant
rs1000054403 -- 139,177,312(+) G/C 3_prime_UTR_variant
rs1000112450 -- 139,168,793(+) T/C intron_variant
rs1000190101 -- 139,164,320(+) G/A intron_variant
rs1000240675 -- 139,171,375(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HECA Gene

Variant ID Type Subtype PubMed ID
esv3610966 CNV gain 21293372
esv32697 CNV gain 17666407

Variation tolerance for HECA Gene

Residual Variation Intolerance Score: 6.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HECA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HECA Gene

Disorders for HECA Gene

MalaCards: The human disease database

(1) MalaCards diseases for HECA Gene - From: DISEASES

Disorder Aliases PubMed IDs
lichen nitidus
  • pinkus' disease
- elite association - COSMIC cancer census association via MalaCards
Search HECA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HECA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HECA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HECA Gene

Publications for HECA Gene

  1. Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (PMID: 11696983) Makino N … Horii A (DNA sequence : the journal of DNA sequencing and mapping 2001) 2 3 4 22 58
  2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. (PMID: 19643820) Dowejko A … Reichert TE (Carcinogenesis 2009) 2 3 22 58
  3. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. (PMID: 22100912) Dowejko A … Reichert TE (Experimental cell research 2012) 2 3 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. (PMID: 16525680) Chien CC … Huang CJ (Oncology reports 2006) 3 22 58

Products for HECA Gene

Sources for HECA Gene

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