Aliases for HDX Gene

Aliases for HDX Gene

  • Highly Divergent Homeobox 2 3 4 5
  • CXorf43 3 4
  • Chromosome X Open Reading Frame 43 2
  • D030011N01Rik 3

External Ids for HDX Gene

Previous HGNC Symbols for HDX Gene

  • CXorf43

Previous GeneCards Identifiers for HDX Gene

  • GC0XM083459
  • GC0XM083572
  • GC0XM077147

Summaries for HDX Gene

GeneCards Summary for HDX Gene

HDX (Highly Divergent Homeobox) is a Protein Coding gene. Diseases associated with HDX include Epilepsy, Familial Temporal Lobe, 6 and Cerebral Atherosclerosis. An important paralog of this gene is POU2F1.

Additional gene information for HDX Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HDX Gene

Genomics for HDX Gene

GeneHancer (GH) Regulatory Elements for HDX Gene

Promoters and enhancers for HDX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ084501 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.6 574 2 POLR2A ATF2 CREB1 ZBTB17 SIN3A RAD21 RXRA REST YY1 ZBTB21 HDX lnc-RPS6KA6-1 lnc-RPS6KA6-3
GH0XJ084469 Enhancer 0.3 Ensembl 13.1 +33.3 33283 0.2 ATF2 ATF7 lnc-RPS6KA6-3 HDX ENSG00000233484
GH0XJ084478 Enhancer 0.2 Ensembl 12.9 +23.0 22983 2 HDX lnc-RPS6KA6-3 lnc-RPS6KA6-1
GH0XJ084859 Enhancer 0.2 Ensembl 4 -356.4 -356363 0.3 HDX piR-31470-556 lnc-SATL1-1
GH0XJ084487 Enhancer 0.7 Ensembl 0.4 +14.4 14383 1.6 EP300 TCF12 SRF MEF2B BATF IRF4 IKZF1 BMI1 NFATC3 ATF2 lnc-RPS6KA6-1 HDX lnc-RPS6KA6-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDX on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HDX

Top Transcription factor binding sites by QIAGEN in the HDX gene promoter:
  • aMEF-2
  • AML1a
  • CUTL1
  • Egr-1
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • Pax-2
  • Pbx1a
  • RelA

Genomic Locations for HDX Gene

Genomic Locations for HDX Gene
chrX:84,317,874-84,502,584
(GRCh38/hg38)
Size:
184,711 bases
Orientation:
Minus strand
chrX:83,572,882-83,757,487
(GRCh37/hg19)
Size:
184,606 bases
Orientation:
Minus strand

Genomic View for HDX Gene

Genes around HDX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDX Gene

Proteins for HDX Gene

  • Protein details for HDX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z353-HDX_HUMAN
    Recommended name:
    Highly divergent homeobox
    Protein Accession:
    Q7Z353
    Secondary Accessions:
    • A8K1Y5
    • B7ZL18
    • Q5JZB4
    • Q96NK7

    Protein attributes for HDX Gene

    Size:
    690 amino acids
    Molecular mass:
    77206 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDX Gene

    Alternative splice isoforms for HDX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDX Gene

Post-translational modifications for HDX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HDX Gene

Domains & Families for HDX Gene

Gene Families for HDX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HDX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HDX Gene

GenScript: Design optimal peptide antigens:
  • Highly divergent homeobox (HDX_HUMAN)
genes like me logo Genes that share domains with HDX: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HDX Gene

Function for HDX Gene

Phenotypes From GWAS Catalog for HDX Gene

Gene Ontology (GO) - Molecular Function for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HDX: view
genes like me logo Genes that share phenotypes with HDX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDX

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDX Gene

Localization for HDX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDX gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDX: view

Pathways & Interactions for HDX Gene

PathCards logo

SuperPathways for HDX Gene

No Data Available

Interacting Proteins for HDX Gene

;

Gene Ontology (GO) - Biological Process for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with HDX: view

No data available for Pathways by source and SIGNOR curated interactions for HDX Gene

Drugs & Compounds for HDX Gene

No Compound Related Data Available

Transcripts for HDX Gene

mRNA/cDNA for HDX Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDX

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for HDX Gene

GeneLoc Exon Structure for
HDX

Expression for HDX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDX Gene

Protein differential expression in normal tissues from HIPED for HDX Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDX Gene



Protein tissue co-expression partners for HDX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HDX

SOURCE GeneReport for Unigene cluster for HDX Gene:

Hs.559546

Evidence on tissue expression from TISSUES for HDX Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Heart(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with HDX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDX Gene

Orthologs for HDX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HDX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDX 31 30
  • 99.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HDX 31 30
  • 92.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hdx 17 31 30
  • 90.97 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563666 30
  • 90.58 (n)
oppossum
(Monodelphis domestica)
Mammalia HDX 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDX 31
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDX 31 30
  • 79.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDX 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdx 30
  • 64.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797948 30
  • 52.48 (n)
HDX 31
  • 39 (a)
OneToOne
Species where no ortholog for HDX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HDX Gene

ENSEMBL:
Gene Tree for HDX (if available)
TreeFam:
Gene Tree for HDX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDX: view image

Paralogs for HDX Gene

genes like me logo Genes that share paralogs with HDX: view

Variants for HDX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HDX Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
711145 Benign: not provided 84,468,904(-) G/A SYNONYMOUS_VARIANT
717642 Benign: not provided 84,469,369(-) A/G SYNONYMOUS_VARIANT
777795 Benign: not provided 84,469,012(-) G/A SYNONYMOUS_VARIANT
777796 Benign: not provided 84,469,146(-) C/T MISSENSE_VARIANT
784565 Benign: not provided 84,326,256(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HDX Gene

Structural Variations from Database of Genomic Variants (DGV) for HDX Gene

Variant ID Type Subtype PubMed ID
esv2740264 CNV deletion 23290073
nsv519860 CNV gain 19592680

Variation tolerance for HDX Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDX Gene

Human Gene Mutation Database (HGMD)
HDX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDX Gene

Disorders for HDX Gene

MalaCards: The human disease database

(2) MalaCards diseases for HDX Gene - From: DISEASES

Disorder Aliases PubMed IDs
epilepsy, familial temporal lobe, 6
  • etl6
cerebral atherosclerosis
  • intracranial arteriosclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HDX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HDX

genes like me logo Genes that share disorders with HDX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HDX Gene

Publications for HDX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Promoter-associated proteins of EPAS1 identified by enChIP-MS - A putative role of HDX as a negative regulator. (PMID: 29577908) Hamidian A … Mohlin S (Biochemical and biophysical research communications 2018) 3 54
  3. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. (PMID: 28581483) Scott DC … Guy RK (Nature chemical biology 2017) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. (PMID: 27591049) Elliott PR … Gyrd-Hansen M (Molecular cell 2016) 3 54

Products for HDX Gene

Sources for HDX Gene