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Aliases for HDX Gene

Aliases for HDX Gene

  • Highly Divergent Homeobox 2 3 5
  • CXorf43 3 4
  • Chromosome X Open Reading Frame 43 2
  • D030011N01Rik 3

External Ids for HDX Gene

Previous HGNC Symbols for HDX Gene

  • CXorf43

Previous GeneCards Identifiers for HDX Gene

  • GC0XM083459
  • GC0XM083572
  • GC0XM077147

Summaries for HDX Gene

GeneCards Summary for HDX Gene

HDX (Highly Divergent Homeobox) is a Protein Coding gene.

Additional gene information for HDX Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDX Gene

Genomics for HDX Gene

GeneHancer (GH) Regulatory Elements for HDX Gene

Promoters and enhancers for HDX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI084501 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.5 487 1.8 TAF1 L3MBTL2 ZBTB21 REST RAD21 ATF2 YY1 POLR2A CREB1 CHD2 HDX ENSG00000233484
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HDX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HDX gene promoter:

Genomic Locations for HDX Gene

Genomic Locations for HDX Gene
chrX:84,317,874-84,502,584
(GRCh38/hg38)
Size:
184,711 bases
Orientation:
Minus strand
chrX:83,572,882-83,757,487
(GRCh37/hg19)

Genomic View for HDX Gene

Genes around HDX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDX Gene

Proteins for HDX Gene

  • Protein details for HDX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z353-HDX_HUMAN
    Recommended name:
    Highly divergent homeobox
    Protein Accession:
    Q7Z353
    Secondary Accessions:
    • A8K1Y5
    • B7ZL18
    • Q5JZB4
    • Q96NK7

    Protein attributes for HDX Gene

    Size:
    690 amino acids
    Molecular mass:
    77206 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI42095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDX Gene

    Alternative splice isoforms for HDX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDX Gene

Post-translational modifications for HDX Gene

No Post-translational modifications

No data available for DME Specific Peptides for HDX Gene

Domains & Families for HDX Gene

Gene Families for HDX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HDX Gene

Suggested Antigen Peptide Sequences for HDX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HDX: view

No data available for UniProtKB/Swiss-Prot for HDX Gene

Function for HDX Gene

Phenotypes From GWAS Catalog for HDX Gene

Gene Ontology (GO) - Molecular Function for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HDX: view
genes like me logo Genes that share phenotypes with HDX: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDX Gene

Localization for HDX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDX gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HDX: view

Pathways & Interactions for HDX Gene

No Data Available

Interacting Proteins for HDX Gene

Gene Ontology (GO) - Biological Process for HDX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HDX Gene

Drugs & Compounds for HDX Gene

No Compound Related Data Available

Transcripts for HDX Gene

Unigene Clusters for HDX Gene

Highly divergent homeobox:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for HDX Gene

GeneLoc Exon Structure for
HDX
ECgene alternative splicing isoforms for
HDX

Expression for HDX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDX Gene

Protein differential expression in normal tissues from HIPED for HDX Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDX Gene



Protein tissue co-expression partners for HDX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDX Gene:

HDX

SOURCE GeneReport for Unigene cluster for HDX Gene:

Hs.559546

Evidence on tissue expression from TISSUES for HDX Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Heart(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with HDX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDX Gene

Orthologs for HDX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HDX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDX 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia HDX 33 34
  • 92.55 (n)
mouse
(Mus musculus)
Mammalia Hdx 33 16 34
  • 90.97 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563666 33
  • 90.58 (n)
oppossum
(Monodelphis domestica)
Mammalia HDX 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HDX 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDX 33 34
  • 79.7 (n)
lizard
(Anolis carolinensis)
Reptilia HDX 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdx 33
  • 64.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797948 33
  • 52.48 (n)
HDX 34
  • 39 (a)
OneToOne
Species where no ortholog for HDX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HDX Gene

ENSEMBL:
Gene Tree for HDX (if available)
TreeFam:
Gene Tree for HDX (if available)

Paralogs for HDX Gene

No data available for Paralogs for HDX Gene

Variants for HDX Gene

Sequence variations from dbSNP and Humsavar for HDX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000004518 -- 84,466,642(-) A/C intron_variant
rs1000012299 -- 84,400,672(-) T/C intron_variant
rs1000046092 -- 84,473,446(-) G/A intron_variant
rs1000047111 -- 84,405,844(-) A/G intron_variant
rs1000067807 -- 84,459,230(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HDX Gene

Variant ID Type Subtype PubMed ID
esv2740264 CNV deletion 23290073
nsv519860 CNV gain 19592680

Variation tolerance for HDX Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDX Gene

Human Gene Mutation Database (HGMD)
HDX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDX Gene

Disorders for HDX Gene

Additional Disease Information for HDX

No disorders were found for HDX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDX Gene

Publications for HDX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 58
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58
  5. 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. (PMID: 20462248) Zuo S … Chen X (Journal of proteome research 2010) 3 58

Products for HDX Gene

Sources for HDX Gene

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