Aliases for HDGFL3 Gene

Aliases for HDGFL3 Gene

  • HDGF Like 3 2 3 5
  • Hepatoma-Derived Growth Factor-Related Protein 3 3 4
  • Hepatoma-Derived Growth Factor 2 3 4
  • HDGFRP3 3 4
  • HDGF-2 3 4
  • HDGF2 3 4
  • HRP-3 3 4
  • Hepatoma-Derived Growth Factor, Related Protein 3 3
  • CGI-142 3

External Ids for HDGFL3 Gene

Previous GeneCards Identifiers for HDGFL3 Gene

  • GC15M083120
  • GC15M083121
  • GC15M083119
  • GC15M083114
  • GC15M083115
  • GC15M083116

Summaries for HDGFL3 Gene

GeneCards Summary for HDGFL3 Gene

HDGFL3 (HDGF Like 3) is a Protein Coding gene. An important paralog of this gene is PSIP1.

UniProtKB/Swiss-Prot Summary for HDGFL3 Gene

Gene Wiki entry for HDGFL3 Gene

Additional gene information for HDGFL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HDGFL3 Gene

Genomics for HDGFL3 Gene

GeneHancer (GH) Regulatory Elements for HDGFL3 Gene

Promoters and enhancers for HDGFL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDGFL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HDGFL3

Genomic Locations for HDGFL3 Gene

Genomic Locations for HDGFL3 Gene
95,281 bases
Minus strand
92,451 bases
Minus strand

Genomic View for HDGFL3 Gene

Genes around HDGFL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFL3 Gene

Proteins for HDGFL3 Gene

  • Protein details for HDGFL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatoma-derived growth factor-related protein 3
    Protein Accession:

    Protein attributes for HDGFL3 Gene

    203 amino acids
    Molecular mass:
    22620 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HDGFL3 Gene

neXtProt entry for HDGFL3 Gene

Post-translational modifications for HDGFL3 Gene

  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for HDGFL3 Gene

No data available for DME Specific Peptides for HDGFL3 Gene

Domains & Families for HDGFL3 Gene

Gene Families for HDGFL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HDGFL3 Gene

  • PWWP domain

Suggested Antigen Peptide Sequences for HDGFL3 Gene

GenScript: Design optimal peptide antigens:
  • Hepatoma-derived growth factor 2 (HDGR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HDGF family.
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFL3: view

Function for HDGFL3 Gene

Molecular function for HDGFL3 Gene

UniProtKB/Swiss-Prot Function:
Enhances DNA synthesis and may play a role in cell proliferation.

Phenotypes From GWAS Catalog for HDGFL3 Gene

Gene Ontology (GO) - Molecular Function for HDGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding ISS --
GO:0008083 growth factor activity IEA --
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with HDGFL3: view
genes like me logo Genes that share phenotypes with HDGFL3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDGFL3 Gene

Localization for HDGFL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDGFL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDGFL3 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005634 nucleus IEA,IDA 10581169
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS,IEA --
genes like me logo Genes that share ontologies with HDGFL3: view

Pathways & Interactions for HDGFL3 Gene

PathCards logo

SuperPathways for HDGFL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HDGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007026 negative regulation of microtubule depolymerization ISS --
GO:0007165 signal transduction IEA --
GO:0008283 cell proliferation NAS 10581169
GO:0031175 neuron projection development ISS --
GO:0046785 microtubule polymerization ISS --
genes like me logo Genes that share ontologies with HDGFL3: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFL3 Gene

Drugs & Compounds for HDGFL3 Gene

No Compound Related Data Available

Transcripts for HDGFL3 Gene

mRNA/cDNA for HDGFL3 Gene

8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFL3 Gene

No ASD Table

Relevant External Links for HDGFL3 Gene

GeneLoc Exon Structure for

Expression for HDGFL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HDGFL3

mRNA Expression by UniProt/SwissProt for HDGFL3 Gene:

Tissue specificity: Detected in testis, heart, spinal cord and brain.

Evidence on tissue expression from TISSUES for HDGFL3 Gene

  • Blood(4.2)
  • Lung(4.1)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with HDGFL3: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL3 Gene

Orthologs for HDGFL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
  • 100 (n)
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
  • 94.54 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
(Mus musculus)
Mammalia Hdgfrp3 31 30
  • 94.39 (n)
Hdgfl3 17
(Rattus norvegicus)
Mammalia Hdgfrp3 30
  • 94.22 (n)
(Bos Taurus)
Mammalia HDGFRP3 31 30
  • 93.92 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 84 (a)
(Gallus gallus)
Aves HDGFRP3 30
  • 87.5 (n)
-- 31
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hdgfrp3 30
  • 81.02 (n)
(Danio rerio)
Actinopterygii CABZ01088864.1 31
  • 100 (a)
hdgfrp3 30
  • 68.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 31
  • 11 (a)
(Caenorhabditis elegans)
Secernentea C06A5.3 31
  • 6 (a)
Species where no ortholog for HDGFL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDGFL3 Gene

Gene Tree for HDGFL3 (if available)
Gene Tree for HDGFL3 (if available)

Paralogs for HDGFL3 Gene

Paralogs for HDGFL3 Gene Pseudogenes for HDGFL3 Gene

genes like me logo Genes that share paralogs with HDGFL3: view

Variants for HDGFL3 Gene

Additional dbSNP identifiers (rs#s) for HDGFL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HDGFL3 Gene

Variant ID Type Subtype PubMed ID
esv2478815 CNV deletion 19546169
esv3420115 CNV insertion 20981092
esv3569787 CNV gain 25503493
nsv1113726 CNV deletion 24896259
nsv1120052 OTHER inversion 24896259
nsv479714 CNV novel sequence insertion 20440878
nsv94888 CNV insertion 16902084
nsv984103 CNV duplication 23825009

Variation tolerance for HDGFL3 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDGFL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HDGFL3 Gene

Disorders for HDGFL3 Gene

Additional Disease Information for HDGFL3

No disorders were found for HDGFL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL3 Gene

Publications for HDGFL3 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 54
  2. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. (PMID: 10581169) Ikegame K … Nakamura H (Biochemical and biophysical research communications 1999) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin. (PMID: 31162607) Tian W … Wang Z (Nucleic acids research 2019) 3 54

Products for HDGFL3 Gene

Sources for HDGFL3 Gene