Aliases for HDGFL2 Gene
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for HDGFL2 Gene
HDGFL2 (HDGF Like 2) is a Protein Coding gene. An important paralog of this gene is PSIP1.
UniProtKB/Swiss-Prot Summary for HDGFL2 Gene
Involved in cellular growth control, through the regulation of cyclin D1 expression.