Aliases for HDGFL1 Gene

Aliases for HDGFL1 Gene

  • HDGF Like 1 2 3 5
  • Hepatoma-Derived Growth Factor-Like Protein 1 3 4
  • Hepatoma Derived Growth Factor-Like 1 2 3
  • PWWP Domain-Containing Protein 1 3 4
  • PWWP Domain Containing 1 2 3
  • DJ309H15.1 2 3
  • Hdgfrp1 2 3
  • HRP-1 2 3
  • PWWP1 3 4
  • HDGF (Hepatoma-Derived Growth Factor) Like 3
  • Testicular Tissue Protein Li 84 3
  • HDGFL1 5

External Ids for HDGFL1 Gene

Previous HGNC Symbols for HDGFL1 Gene

  • PWWP1

Previous GeneCards Identifiers for HDGFL1 Gene

  • GC06P022678

Summaries for HDGFL1 Gene

GeneCards Summary for HDGFL1 Gene

HDGFL1 (HDGF Like 1) is a Protein Coding gene. An important paralog of this gene is HDGF.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HDGFL1 Gene

Genomics for HDGFL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HDGFL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J022320 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 10.2 -248.1 -248065 3 NR2C1 BATF JUND NR2F1 NR2F6 ATF2 JUNB BHLHE40 PKNOX1 EED HDGFL1 piR-43106-173 PRL CASC15
GH06J022612 Enhancer 0.8 Ensembl ENCODE 11.5 +44.2 44235 2.8 ATF2 ZEB1 ZNF843 INSM2 MAFK ZBTB21 BHLHE40 ZNF398 GATA2 TRIM28 HDGFL1 RF00017-4874 ENSG00000228772 CASC15
GH06J022655 Enhancer 0.8 Ensembl ENCODE 10.7 +88.0 88035 3.6 TRIM22 NR2F1 ZNF217 PKNOX1 ARID3A IKZF1 TARDBP TBL1XR1 MTA2 IKZF2 ENSG00000286954 HDGFL1 HSALNG0048560 LOC105374973 LOC105374972
GH06J022631 Enhancer 0.4 Ensembl ENCODE 11.1 +62.7 62734 2.2 EZH2 HDGFL1 HSALNG0048556 RF00017-4874 CASC15
GH06J022654 Enhancer 0.4 Ensembl ENCODE 10.7 +84.7 84717 1 ZNF24 HSALNG0048560 LOC105374973 HDGFL1 LOC105374972 CASC15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDGFL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HDGFL1

Top Transcription factor binding sites by QIAGEN in the HDGFL1 gene promoter:
  • c-Myb
  • c-Myc
  • Evi-1
  • HFH-1
  • Max1
  • POU2F1
  • POU2F1a

Genomic Locations for HDGFL1 Gene

Latest Assembly
chr6:22,569,566-22,571,666
(GRCh38/hg38)
Size:
2,101 bases
Orientation:
Plus strand

Previous Assembly
chr6:22,569,795-22,571,895
(GRCh37/hg19 by Entrez Gene)
Size:
2,101 bases
Orientation:
Plus strand

chr6:22,569,678-22,571,892
(GRCh37/hg19 by Ensembl)
Size:
2,215 bases
Orientation:
Plus strand

Genomic View for HDGFL1 Gene

Genes around HDGFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDGFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDGFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDGFL1 Gene

Proteins for HDGFL1 Gene

  • Protein details for HDGFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGJ6-HDGL1_HUMAN
    Recommended name:
    Hepatoma-derived growth factor-like protein 1
    Protein Accession:
    Q5TGJ6
    Secondary Accessions:
    • Q96MJ6

    Protein attributes for HDGFL1 Gene

    Size:
    251 amino acids
    Molecular mass:
    27234 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HDGFL1 Gene

Post-translational modifications for HDGFL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDGFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HDGFL1 Gene

Domains & Families for HDGFL1 Gene

Gene Families for HDGFL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HDGFL1 Gene

InterPro:
Blocks:
  • PWWP domain

Suggested Antigen Peptide Sequences for HDGFL1 Gene

GenScript: Design optimal peptide antigens:
  • PWWP domain-containing protein 1 (HDGL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5TGJ6

UniProtKB/Swiss-Prot:

HDGL1_HUMAN :
  • Belongs to the HDGF family.
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with HDGFL1: view

Function for HDGFL1 Gene

Phenotypes From GWAS Catalog for HDGFL1 Gene

Gene Ontology (GO) - Molecular Function for HDGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0003712 transcription coregulator activity IBA 21873635
genes like me logo Genes that share ontologies with HDGFL1: view
genes like me logo Genes that share phenotypes with HDGFL1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDGFL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HDGFL1 Gene

Localization for HDGFL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDGFL1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for HDGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with HDGFL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for HDGFL1 Gene

Pathways & Interactions for HDGFL1 Gene

PathCards logo

SuperPathways for HDGFL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HDGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with HDGFL1: view

No data available for Pathways by source and SIGNOR curated interactions for HDGFL1 Gene

Drugs & Compounds for HDGFL1 Gene

No Compound Related Data Available

Transcripts for HDGFL1 Gene

mRNA/cDNA for HDGFL1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDGFL1

Alternative Splicing Database (ASD) splice patterns (SP) for HDGFL1 Gene

No ASD Table

Relevant External Links for HDGFL1 Gene

GeneLoc Exon Structure for
HDGFL1

Expression for HDGFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDGFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for HDGFL1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for HDGFL1 Gene

This gene is overexpressed in Testis (36.9) and Ovary (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HDGFL1 Gene



Protein tissue co-expression partners for HDGFL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HDGFL1

SOURCE GeneReport for Unigene cluster for HDGFL1 Gene:

Hs.629246
genes like me logo Genes that share expression patterns with HDGFL1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDGFL1 Gene

Orthologs for HDGFL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HDGFL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HDGFL1 29 30
  • 95.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HDGFL1 30
  • 62 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Hdgfl1 30
  • 36 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 47 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 41 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii WU:FC32F04 30
  • 8 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7946 30
  • 13 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C06A5.3 30
  • 7 (a)
OneToMany
Species where no ortholog for HDGFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HDGFL1 Gene

ENSEMBL:
Gene Tree for HDGFL1 (if available)
TreeFam:
Gene Tree for HDGFL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDGFL1: view image
Alliance of Genome Resources:
Additional Orthologs for HDGFL1

Paralogs for HDGFL1 Gene

Paralogs for HDGFL1 Gene

(4) SIMAP similar genes for HDGFL1 Gene using alignment to 1 proteins:

  • HDGL1_HUMAN
genes like me logo Genes that share paralogs with HDGFL1: view

Variants for HDGFL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HDGFL1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2076506 -- p.Thr87Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HDGFL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HDGFL1 Gene

Variant ID Type Subtype PubMed ID
nsv830605 CNV gain 17160897

Variation tolerance for HDGFL1 Gene

Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDGFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDGFL1
Leiden Open Variation Database (LOVD)
HDGFL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDGFL1 Gene

Disorders for HDGFL1 Gene

Additional Disease Information for HDGFL1

No disorders were found for HDGFL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDGFL1 Gene

Publications for HDGFL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans. (PMID: 25224454) Li J … Lange EM (Human molecular genetics 2015) 3
  3. Genome-wide association study of parity in Bangladeshi women. (PMID: 25742292) Aschebrook-Kilfoy B … Ahsan H (PloS one 2015) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. (PMID: 20509080) Ansermet F … Paoloni-Giacobino A (Journal of child sexual abuse 2010) 3

Products for HDGFL1 Gene

Sources for HDGFL1 Gene