Aliases for HDGF Gene
External Ids for HDGF Gene
Previous GeneCards Identifiers for HDGF Gene
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
GeneCards Summary for HDGF Gene
HDGF (Heparin Binding Growth Factor) is a Protein Coding gene. Diseases associated with HDGF include Hepatocellular Carcinoma and Lung Cancer. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is HDGFL1.
UniProtKB/Swiss-Prot Summary for HDGF Gene
[Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
[Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719).
[Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).