Aliases for HDGF Gene
- Heparin Binding Growth Factor 2 3 5
- High Mobility Group Protein 1-Like 2 3 4
- Hepatoma-Derived Growth Factor 3 4
- Hepatoma Derived Growth Factor 2 3
- HMG1L2 3 4
- Hepatoma-Derived Growth Factor (High-Mobility Group Protein 1-Like) 2
- Epididymis Secretory Sperm Binding Protein 3
- High-Mobility Group Protein 1-Like 2
- HMG-1L2 4
External Ids for HDGF Gene
Previous GeneCards Identifiers for HDGF Gene
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
GeneCards Summary for HDGF Gene
HDGF (Heparin Binding Growth Factor) is a Protein Coding gene. Diseases associated with HDGF include Cornea Cancer and Lung Cancer. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is HDGFL1.
UniProtKB/Swiss-Prot Summary for HDGF Gene
Isoform 1: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
Isoform 2: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719).
Isoform 3: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).