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Aliases for HDDC2 Gene

Aliases for HDDC2 Gene

  • HD Domain Containing 2 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 2 3 4
  • HCV NS5A-Transactivated Protein 2 3 4
  • C6orf74 3 4
  • NS5ATP2 3 4
  • Chromosome 6 Open Reading Frame 74 2
  • Testicular Tissue Protein Li 83 3
  • HD Domain-Containing Protein 2 3
  • DJ167O5.2 3
  • CGI-130 3

External Ids for HDDC2 Gene

Previous HGNC Symbols for HDDC2 Gene

  • C6orf74

Previous GeneCards Identifiers for HDDC2 Gene

  • GC06M125639
  • GC06M123173
  • GC06M125596

Summaries for HDDC2 Gene

GeneCards Summary for HDDC2 Gene

HDDC2 (HD Domain Containing 2) is a Protein Coding gene. Diseases associated with HDDC2 include Hepatitis C Virus.

Additional gene information for HDDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDDC2 Gene

Genomics for HDDC2 Gene

GeneHancer (GH) Regulatory Elements for HDDC2 Gene

Promoters and enhancers for HDDC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I125299 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 582.4 +0.5 506 4.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 HDDC2 RNF217 TRMT11 LOC100126584
GH06I125153 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.8 +147.8 147771 2.4 HDGF FOXA2 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 TPD52L1 HDDC2 LOC100126584
GH06I125200 Enhancer 1.2 Ensembl ENCODE 21.4 +100.2 100188 2.8 HDGF CLOCK NEUROD1 SIN3A ZNF2 YY1 ZNF766 ZNF213 FOS KLF13 HDDC2 TPD52L1 LOC100126584
GH06I125203 Enhancer 0.9 Ensembl ENCODE 24.5 +98.5 98487 0.3 LEF1 USF1 TAF9B NFRKB BACH1 ZNF316 FOXK2 POLR2A FOSL2 NFE2 HDDC2 LOC100126584 TPD52L1
GH06I125187 Enhancer 0.9 Ensembl ENCODE 16.3 +113.5 113517 1.7 HDAC1 ATF1 GTF2E2 TEAD4 BACH1 FOSL1 ZNF766 VEZF1 ATF7 CREM HDDC2 LOC100126584 TPD52L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HDDC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HDDC2 gene promoter:

Genomic Locations for HDDC2 Gene

Genomic Locations for HDDC2 Gene
82,180 bases
Minus strand

Genomic View for HDDC2 Gene

Genes around HDDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDDC2 Gene

Proteins for HDDC2 Gene

  • Protein details for HDDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HD domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5TDQ4
    • Q6NZ49
    • Q9BTT2
    • Q9BV31
    • Q9Y3D1

    Protein attributes for HDDC2 Gene

    204 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34125.1; Type=Miscellaneous discrepancy; Note=Correction of a non-canonical splice junction.; Evidence={ECO:0000305}; Sequence=AAH03357.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDDC2 Gene

    Alternative splice isoforms for HDDC2 Gene


neXtProt entry for HDDC2 Gene

Post-translational modifications for HDDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HDDC2 Gene

No data available for DME Specific Peptides for HDDC2 Gene

Domains & Families for HDDC2 Gene

Gene Families for HDDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HDDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HDDC2 family.
  • Belongs to the HDDC2 family.
genes like me logo Genes that share domains with HDDC2: view

Function for HDDC2 Gene

Gene Ontology (GO) - Molecular Function for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with HDDC2: view
genes like me logo Genes that share phenotypes with HDDC2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HDDC2 Gene

Localization for HDDC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDDC2 gene
Compartment Confidence
extracellular 5
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HDDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with HDDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HDDC2 Gene

Pathways & Interactions for HDDC2 Gene

SuperPathways for HDDC2 Gene

No Data Available

Interacting Proteins for HDDC2 Gene

Gene Ontology (GO) - Biological Process for HDDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for HDDC2 Gene

Drugs & Compounds for HDDC2 Gene

No Compound Related Data Available

Transcripts for HDDC2 Gene

Unigene Clusters for HDDC2 Gene

HD domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDDC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - -
SP11: - -
SP12: -

Relevant External Links for HDDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HDDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDDC2 Gene

Protein differential expression in normal tissues from HIPED for HDDC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Skin (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HDDC2 Gene

Protein tissue co-expression partners for HDDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDDC2 Gene:


SOURCE GeneReport for Unigene cluster for HDDC2 Gene:


Evidence on tissue expression from TISSUES for HDDC2 Gene

  • Nervous system(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with HDDC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDDC2 Gene

Orthologs for HDDC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HDDC2 33 34
  • 99.18 (n)
(Bos Taurus)
Mammalia HDDC2 34 33
  • 91.01 (n)
(Canis familiaris)
Mammalia HDDC2 34 33
  • 86.93 (n)
(Mus musculus)
Mammalia Hddc2 33 16 34
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Hddc2 33
  • 83.58 (n)
(Monodelphis domestica)
Mammalia HDDC2 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia HDDC2 34
  • 75 (a)
(Gallus gallus)
Aves HDDC2 33 34
  • 74.91 (n)
(Anolis carolinensis)
Reptilia HDDC2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hddc2 33
  • 69.05 (n)
Str.10992 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23921 33
(Danio rerio)
Actinopterygii hddc2 33 34
  • 64.13 (n)
wufb71h08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14203 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012582 33
  • 50.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11050 33 34
  • 48.85 (n)
(Caenorhabditis elegans)
Secernentea F45F2.9 33 34
  • 49.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBR242W 33
  • 51.02 (n)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL036C 33
  • 50.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06798g 33
  • 45.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23820 33
  • 59.3 (n)
(Oryza sativa)
Liliopsida Os02g0179100 33
  • 53.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4G3.17 33
  • 52.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04470 33
  • 46.71 (n)
Species where no ortholog for HDDC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDDC2 Gene

Gene Tree for HDDC2 (if available)
Gene Tree for HDDC2 (if available)

Paralogs for HDDC2 Gene

No data available for Paralogs for HDDC2 Gene

Variants for HDDC2 Gene

Sequence variations from dbSNP and Humsavar for HDDC2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000135485 -- 125,288,666(-) C/T intron_variant
rs1000177464 -- 125,295,010(-) A/G intron_variant
rs1000356610 -- 125,292,112(-) G/C intron_variant
rs1000424650 -- 125,285,582(-) G/A intron_variant
rs1000437611 -- 125,282,688(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HDDC2 Gene

Variant ID Type Subtype PubMed ID
nsv604601 CNV loss 21841781
nsv820070 CNV gain 19587683

Variation tolerance for HDDC2 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDDC2 Gene

Disorders for HDDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HDDC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search HDDC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HDDC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HDDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HDDC2 Gene

Publications for HDDC2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58

Products for HDDC2 Gene

Sources for HDDC2 Gene

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