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Aliases for HDAC9 Gene

Aliases for HDAC9 Gene

  • Histone Deacetylase 9 2 3 3 5
  • Histone Deacetylase 7B 3 4
  • HDAC7B 3 4
  • HDAC7 3 4
  • HD7b 3 4
  • HDRP 3 4
  • MITR 3 4
  • HD7 3 4
  • HD9 3 4
  • MEF-2 Interacting Transcription Repressor (MITR) Protein 3
  • MEF2-Interacting Transcription Repressor MITR 4
  • Histone Deacetylase 4/5-Related Protein 3
  • Histone Deacetylase-Related Protein 4
  • EC 3.5.1.98 4
  • KIAA0744 4
  • HDAC9FL 3
  • HDAC9B 3
  • HDAC 3

External Ids for HDAC9 Gene

Previous GeneCards Identifiers for HDAC9 Gene

  • GC07P018279
  • GC07P018308
  • GC07P018501

Summaries for HDAC9 Gene

Entrez Gene Summary for HDAC9 Gene

  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC9 Gene

HDAC9 (Histone Deacetylase 9) is a Protein Coding gene. Diseases associated with HDAC9 include Gastrointestinal Neuroendocrine Tumor and Cutaneous T Cell Lymphoma. Among its related pathways are Notch signaling pathway (KEGG) and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include transcription factor binding and histone deacetylase binding. An important paralog of this gene is HDAC5.

UniProtKB/Swiss-Prot for HDAC9 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.

  • Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Tocris Summary for HDAC9 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC9 Gene

Additional gene information for HDAC9 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC9 Gene

Genomics for HDAC9 Gene

GeneHancer (GH) Regulatory Elements for HDAC9 Gene

Promoters and enhancers for HDAC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J018494 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.1 +409.1 409079 3.6 NANOG MAX MEF2B ATF2 RELA SP1 ZNF217 JUND GATA3 POLR2A HDAC9 ENSG00000225000 LOC100419901
GH07J018086 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 -0.3 -341 1.2 ZNF335 GLIS2 ZNF362 SP3 ZBTB11 ZNF398 ZEB2 ZSCAN16 GLIS1 ZNF341 HDAC9 PIR44305
GH07J018535 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +449.2 449197 0.3 NFE2L2 HDAC9 LOC100419901 ENSG00000225000
GH07J018177 Enhancer 1.2 Ensembl ENCODE 10.5 +91.2 91227 2.1 HDGF PKNOX1 ATF1 ARNT IRF4 GTF3C2 TCF12 ZNF766 GATA2 FOS HDAC9 MIR1302-6 GC07M018234
GH07J018289 Enhancer 0.6 Ensembl ENCODE 16.2 +204.8 204759 4.2 ATF4 HMBOX1 RUNX3 HDAC9 GC07M018234 MIR1302-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDAC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HDAC9 gene promoter:
  • aMEF-2
  • MEF-2A

Genomic Locations for HDAC9 Gene

Genomic Locations for HDAC9 Gene
chr7:18,086,942-19,002,416
(GRCh38/hg38)
Size:
915,475 bases
Orientation:
Plus strand
chr7:18,126,572-19,042,039
(GRCh37/hg19)
Size:
915,468 bases
Orientation:
Plus strand

Genomic View for HDAC9 Gene

Genes around HDAC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC9 Gene

Proteins for HDAC9 Gene

  • Protein details for HDAC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKV0-HDAC9_HUMAN
    Recommended name:
    Histone deacetylase 9
    Protein Accession:
    Q9UKV0
    Secondary Accessions:
    • A7E2F3
    • B7Z4I4
    • B7Z917
    • B7Z928
    • B7Z940
    • C9JS87
    • E7EX34
    • F8W9E0
    • O94845
    • O95028
    • Q2M2R6
    • Q86SL1
    • Q86US3

    Protein attributes for HDAC9 Gene

    Size:
    1011 amino acids
    Molecular mass:
    111297 Da
    Quaternary structure:
    • Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6. Interacts with FOXP3 in the absence of T-cell stimulation.
    SequenceCaution:
    • Sequence=BAA34464.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HDAC9 Gene

neXtProt entry for HDAC9 Gene

Post-translational modifications for HDAC9 Gene

  • Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for HDAC9
  • Santa Cruz Biotechnology (SCBT) Antibodies for HDAC9

No data available for DME Specific Peptides for HDAC9 Gene

Domains & Families for HDAC9 Gene

Gene Families for HDAC9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HDAC9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKV0

UniProtKB/Swiss-Prot:

HDAC9_HUMAN :
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC9: view

Function for HDAC9 Gene

Molecular function for HDAC9 Gene

UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
UniProtKB/Swiss-Prot Function:
Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid.

Enzyme Numbers (IUBMB) for HDAC9 Gene

Phenotypes From GWAS Catalog for HDAC9 Gene

Gene Ontology (GO) - Molecular Function for HDAC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity ISS --
GO:0004407 histone deacetylase activity IDA 11535832
GO:0005080 protein kinase C binding IPI 20188095
GO:0005515 protein binding IPI 12590135
GO:0008134 transcription factor binding IPI,IDA 10748098
genes like me logo Genes that share ontologies with HDAC9: view
genes like me logo Genes that share phenotypes with HDAC9: view

Animal Models for HDAC9 Gene

MGI Knock Outs for HDAC9:

Animal Model Products

  • Taconic Biosciences Mouse Models for HDAC9

CRISPR Products

miRNA for HDAC9 Gene

miRTarBase miRNAs that target HDAC9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC9

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC9 Gene

Localization for HDAC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC9 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDAC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 12711221
GO:0005634 nucleus IDA,IEA 12590135
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15567413
GO:0005737 cytoplasm TAS 12711221
genes like me logo Genes that share ontologies with HDAC9: view

Pathways & Interactions for HDAC9 Gene

genes like me logo Genes that share pathways with HDAC9: view

SIGNOR curated interactions for HDAC9 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HDAC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10655483
GO:0001975 response to amphetamine IEA --
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HDAC9: view

Drugs & Compounds for HDAC9 Gene

(97) Drugs for HDAC9 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Valproic Acid Approved, Investigational Pharma inhibitor, Target HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 333
Belinostat Approved, Investigational Pharma Inhibitor, Target Histone deacetylase (HDAC)inhibitors 42
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor, Target Histone deacetylase (HDAC)inhibitors 136
Parthenolide Approved, Investigational Pharma 4
Romidepsin Approved, Investigational Pharma inhibitor Histone deacetylase (HDAC)inhibitors 89

(47) Additional Compounds for HDAC9 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-ene-Valproic acid
  • 4-En-valproic acid
  • 4-Ene-vpa
  • 4-En-valproate
  • 4-Ene-valproate
  • 2-Propyl-4-pentenoic acid, (+-)-isomer
Valproic acid, sodium salt
1069-66-5

(3) Tocris Compounds for HDAC9 Gene

Compound Action Cas Number
Apicidin Potent histone deacetylase inhibitor 183506-66-3
PCI 34051 Potent and selective HDAC8 inhibitor 950762-95-5
Valproic acid, sodium salt Histone deacetylase inhibitor 1069-66-5
genes like me logo Genes that share compounds with HDAC9: view

Transcripts for HDAC9 Gene

Unigene Clusters for HDAC9 Gene

Histone deacetylase 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - -
SP3:

ExUns: 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:

Relevant External Links for HDAC9 Gene

GeneLoc Exon Structure for
HDAC9
ECgene alternative splicing isoforms for
HDAC9

Expression for HDAC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDAC9 Gene

Protein differential expression in normal tissues from HIPED for HDAC9 Gene

This gene is overexpressed in Heart (41.1) and Prostate (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HDAC9 Gene



Protein tissue co-expression partners for HDAC9 Gene

NURSA nuclear receptor signaling pathways regulating expression of HDAC9 Gene:

HDAC9

SOURCE GeneReport for Unigene cluster for HDAC9 Gene:

Hs.196054

mRNA Expression by UniProt/SwissProt for HDAC9 Gene:

Q9UKV0-HDAC9_HUMAN
Tissue specificity: Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).

Evidence on tissue expression from TISSUES for HDAC9 Gene

  • Nervous system(4.6)
  • Eye(4)
  • Muscle(2.3)
  • Blood(2)
  • Heart(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HDAC9 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • eye
  • head
genes like me logo Genes that share expression patterns with HDAC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HDAC9 Gene

Orthologs for HDAC9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC9 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC9 34 33
  • 95.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC9 34 33
  • 94.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac9 33
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Hdac9 16 34 33
  • 89.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC9 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HDAC9 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDAC9 34 33
  • 81.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia hdac9-A 33
zebrafish
(Danio rerio)
Actinopterygii hdac9b 34
  • 54 (a)
OneToOne
hdac9 33
fruit fly
(Drosophila melanogaster)
Insecta HDAC4 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hda-4 34
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
ManyToMany
CSA.5129 34
  • 32 (a)
ManyToMany
Species where no ortholog for HDAC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HDAC9 Gene

ENSEMBL:
Gene Tree for HDAC9 (if available)
TreeFam:
Gene Tree for HDAC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDAC9: view image

Paralogs for HDAC9 Gene

Paralogs for HDAC9 Gene

(13) SIMAP similar genes for HDAC9 Gene using alignment to 15 proteins:

  • HDAC9_HUMAN
  • B5MCF1_HUMAN
  • C9IZS0_HUMAN
  • C9J1W4_HUMAN
  • C9J835_HUMAN
  • C9JD56_HUMAN
  • C9JLX1_HUMAN
  • F8WDS2_HUMAN
  • Q75N08_HUMAN
  • Q75N09_HUMAN
  • Q75N10_HUMAN
  • Q75N14_HUMAN
  • Q75N15_HUMAN
  • Q75N16_HUMAN
  • Q9Y6V1_HUMAN
genes like me logo Genes that share paralogs with HDAC9: view

Variants for HDAC9 Gene

Sequence variations from dbSNP and Humsavar for HDAC9 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1060499865 likely-benign, not specified 18,793,416(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs1178127 benign, not specified 18,727,720(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs2389998 benign, not specified 18,954,247(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant
rs35614472 benign, not specified 18,647,919(+) A/G/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000004144 -- 18,860,205(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC9 Gene

Variant ID Type Subtype PubMed ID
esv2442723 CNV deletion 19546169
esv2476785 CNV deletion 19546169
esv2582410 CNV deletion 19546169
esv2660622 CNV deletion 23128226
esv2664987 CNV deletion 23128226
esv2668991 CNV deletion 23128226
esv2676378 CNV deletion 23128226
esv2734072 CNV deletion 23290073
esv2734074 CNV deletion 23290073
esv2734075 CNV deletion 23290073
esv2734076 CNV deletion 23290073
esv2734077 CNV deletion 23290073
esv2734078 CNV deletion 23290073
esv2759516 CNV loss 17122850
esv2762656 CNV loss 21179565
esv29862 CNV loss 19812545
esv32771 CNV gain 17666407
esv3304893 CNV mobile element insertion 20981092
esv3306306 CNV mobile element insertion 20981092
esv3306527 CNV mobile element insertion 20981092
esv3306932 CNV mobile element insertion 20981092
esv3308523 CNV mobile element insertion 20981092
esv3354676 CNV insertion 20981092
esv3374815 CNV insertion 20981092
esv3380997 CNV insertion 20981092
esv3389040 CNV insertion 20981092
esv3393778 CNV insertion 20981092
esv3427043 CNV insertion 20981092
esv3436547 CNV insertion 20981092
esv3437954 CNV insertion 20981092
esv3441757 CNV insertion 20981092
esv3541277 CNV deletion 23714750
esv3541281 CNV deletion 23714750
esv3571681 CNV loss 25503493
esv3612445 CNV loss 21293372
esv3612451 CNV gain 21293372
esv3612452 CNV loss 21293372
esv3612453 CNV loss 21293372
esv3612455 CNV loss 21293372
esv3612457 CNV loss 21293372
esv3612458 CNV loss 21293372
esv3612459 CNV loss 21293372
esv3612460 CNV loss 21293372
esv3891083 CNV gain 25118596
esv999263 CNV deletion 20482838
nsv1022746 CNV gain 25217958
nsv1025023 CNV gain 25217958
nsv1027814 CNV gain 25217958
nsv1029901 CNV loss 25217958
nsv1030062 CNV loss 25217958
nsv1075015 CNV deletion 25765185
nsv1109850 CNV deletion 24896259
nsv1109851 CNV deletion 24896259
nsv1114921 CNV deletion 24896259
nsv1161508 CNV duplication 26073780
nsv366882 CNV deletion 16902084
nsv477470 CNV novel sequence insertion 20440878
nsv516893 CNV loss 19592680
nsv523468 CNV loss 19592680
nsv523497 CNV loss 19592680
nsv528759 CNV loss 19592680
nsv5648 CNV insertion 18451855
nsv606357 CNV gain 21841781
nsv606358 CNV gain 21841781
nsv606359 CNV loss 21841781
nsv8065 CNV loss 18304495
nsv830914 CNV gain 17160897
nsv830916 CNV gain 17160897
nsv830917 CNV gain 17160897
nsv970449 CNV duplication 23825009

Variation tolerance for HDAC9 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDAC9 Gene

Human Gene Mutation Database (HGMD)
HDAC9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC9 Gene

Disorders for HDAC9 Gene

MalaCards: The human disease database

(6) MalaCards diseases for HDAC9 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal neuroendocrine tumor
  • malignant gastrointestinal neuroendocrine tumor
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
huntington disease
  • hd
spinal muscular atrophy
  • sma
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards
Search HDAC9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HDAC9_HUMAN
  • Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. {ECO:0000269 PubMed:12706107}.

Additional Disease Information for HDAC9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HDAC9: view

No data available for Genatlas for HDAC9 Gene

Publications for HDAC9 Gene

  1. The histone deacetylase 9 gene encodes multiple protein isoforms. (PMID: 12590135) Petrie K … Zelent A (The Journal of biological chemistry 2003) 3 4 22 58
  2. Cloning and characterization of a histone deacetylase, HDAC9. (PMID: 11535832) Zhou X … Richon VM (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58
  3. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. (PMID: 10655483) Zhou X … Marks PA (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58
  4. MEF-2 function is modified by a novel co-repressor, MITR. (PMID: 10487760) Sparrow DB … Mohun TJ (The EMBO journal 1999) 2 3 4 58
  5. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. (PMID: 10523670) Wang AH … Yang XJ (Molecular and cellular biology 1999) 2 3 4 58

Products for HDAC9 Gene

Sources for HDAC9 Gene

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