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Aliases for HDAC7 Gene

Aliases for HDAC7 Gene

  • Histone Deacetylase 7 2 3 3 5
  • Histone Deacetylase 7A 2 3 4
  • HDAC7A 3 4
  • HD7 3 4
  • EC 3.5.1.98 4
  • HD7A 3
  • HD7a 4

External Ids for HDAC7 Gene

Previous HGNC Symbols for HDAC7 Gene

  • HDAC7A

Previous GeneCards Identifiers for HDAC7 Gene

  • GC12M046463
  • GC12M048176
  • GC12M045207

Summaries for HDAC7 Gene

Entrez Gene Summary for HDAC7 Gene

  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC7 Gene

HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is HDAC4.

UniProtKB/Swiss-Prot for HDAC7 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Tocris Summary for HDAC7 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC7 Gene

Additional gene information for HDAC7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC7 Gene

Genomics for HDAC7 Gene

GeneHancer (GH) Regulatory Elements for HDAC7 Gene

Promoters and enhancers for HDAC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J047804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 680.9 +15.4 15384 25.6 ZFP64 FEZF1 DMAP1 IRF4 ZNF213 ZNF143 SP3 MEF2D GLIS1 NBN HDAC7 ENSG00000274737 CCNT1 LOC390314 KANSL2 SENP1 RAPGEF3 ASB8 VDR SLC48A1
GH12J047831 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 665.3 -1.2 -1195 5 HDGF ATF1 TCF12 GATA2 ATF7 RUNX3 MCM3 ATF4 GMEB1 SMARCA4 HDAC7 LOC390314 SENP1 LOC102725258 CCNT1 CCDC184 H1FNT KANSL2 RPAP3 CACNB3
GH12J048104 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.1 -273.2 -273158 4.1 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SENP1 PFKM DDX23 CCNT1 KMT2D KANSL2 LOC390314 RPL37P19 RPAP3 HDAC7
GH12J047768 Enhancer 1.1 ENCODE dbSUPER 35.5 +64.4 64424 0.9 PKNOX1 FOXA2 ARID4B FEZF1 ZNF121 ZNF213 KLF7 ZNF548 SP3 TSHZ1 ENSG00000277173 CCNT1 KANSL2 HDAC7 ENSG00000268069 RPAP3 SENP1 CCDC184 RAPGEF3 GC12M047752
GH12J047902 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.5 -71.2 -71166 3.4 SMAD1 SIN3A GLI4 ZNF2 IRF4 YY1 GLIS2 ZNF213 ZNF143 ZFP91 VDR ENSG00000278385 GC12P047906 DDX23 CCNT1 SENP1 LOC390314 KANSL2 HDAC7 ENSG00000268069
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDAC7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HDAC7 gene promoter:
  • Pax-4a
  • E47
  • c-Ets-1
  • SEF-1 (1)
  • Nkx2-5
  • Zic3
  • FAC1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for HDAC7 Gene

Genomic Locations for HDAC7 Gene
chr12:47,782,722-47,833,132
(GRCh38/hg38)
Size:
50,411 bases
Orientation:
Minus strand
chr12:48,176,505-48,226,915
(GRCh37/hg19)
Size:
50,411 bases
Orientation:
Minus strand

Genomic View for HDAC7 Gene

Genes around HDAC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC7 Gene

Proteins for HDAC7 Gene

  • Protein details for HDAC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUI4-HDAC7_HUMAN
    Recommended name:
    Histone deacetylase 7
    Protein Accession:
    Q8WUI4
    Secondary Accessions:
    • B3KY08
    • B4DWI0
    • B4E0Q5
    • Q6P1W9
    • Q6W9G7
    • Q7Z4K2
    • Q7Z5I1
    • Q96K01
    • Q9BR73
    • Q9H7L0
    • Q9NW41
    • Q9NWA9
    • Q9NYK9
    • Q9UFU7

    Protein attributes for HDAC7 Gene

    Size:
    952 amino acids
    Molecular mass:
    102927 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15 (By similarity). Interacts with PML (isoform PML-4). Interacts with FOXP3.
    Miscellaneous:
    • Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.
    SequenceCaution:
    • Sequence=AAF63491.1; Type=Frameshift; Positions=877; Evidence={ECO:0000305}; Sequence=BAA91474.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91545.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15759.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55363.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC56929.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC7 Gene

    Alternative splice isoforms for HDAC7 Gene

neXtProt entry for HDAC7 Gene

Post-translational modifications for HDAC7 Gene

  • May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HDAC7 Gene

Domains & Families for HDAC7 Gene

Gene Families for HDAC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HDAC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUI4

UniProtKB/Swiss-Prot:

HDAC7_HUMAN :
  • The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Domain:
  • The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC7: view

Function for HDAC7 Gene

Molecular function for HDAC7 Gene

UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Enzyme Numbers (IUBMB) for HDAC7 Gene

Phenotypes From GWAS Catalog for HDAC7 Gene

Gene Ontology (GO) - Molecular Function for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0004407 histone deacetylase activity IEA --
GO:0005080 protein kinase C binding IPI 20188095
GO:0005515 protein binding IPI 15161933
genes like me logo Genes that share ontologies with HDAC7: view
genes like me logo Genes that share phenotypes with HDAC7: view

Animal Models for HDAC7 Gene

MGI Knock Outs for HDAC7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC7

Clone Products

  • Addgene plasmids for HDAC7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC7 Gene

Localization for HDAC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC7 Gene

Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IEA --
GO:0005634 nucleus IDA,IEA 16980613
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 16980613
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HDAC7: view

Pathways & Interactions for HDAC7 Gene

genes like me logo Genes that share pathways with HDAC7: view

SIGNOR curated interactions for HDAC7 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HDAC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001570 vasculogenesis IEA --
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HDAC7: view

Drugs & Compounds for HDAC7 Gene

(26) Drugs for HDAC7 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Inhibitor, Target Histone deacetylase (HDAC)inhibitors 42
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor, Target Histone deacetylase (HDAC)inhibitors 136
Romidepsin Approved, Investigational Pharma inhibitor Histone deacetylase (HDAC)inhibitors 89
Valproic Acid Approved, Investigational Pharma inhibitor HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 333
Vorinostat Approved, Investigational Pharma inhibitor HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 254

(1) Additional Compounds for HDAC7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Valproic acid, sodium salt
1069-66-5

(3) Tocris Compounds for HDAC7 Gene

Compound Action Cas Number
Apicidin Potent histone deacetylase inhibitor 183506-66-3
PCI 34051 Potent and selective HDAC8 inhibitor 950762-95-5
Valproic acid, sodium salt Histone deacetylase inhibitor 1069-66-5
genes like me logo Genes that share compounds with HDAC7: view

Transcripts for HDAC7 Gene

Unigene Clusters for HDAC7 Gene

Histone deacetylase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC7

Clone Products

  • Addgene plasmids for HDAC7

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a ·
SP1: -
SP2: - - - - - -
SP3: - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - -
SP15: - - - - - - - - -
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 33b ^ 34a · 34b · 34c · 34d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for HDAC7 Gene

GeneLoc Exon Structure for
HDAC7
ECgene alternative splicing isoforms for
HDAC7

Expression for HDAC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDAC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDAC7 Gene

This gene is overexpressed in Prostate (39.9) and Urinary Bladder (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HDAC7 Gene



Protein tissue co-expression partners for HDAC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDAC7 Gene:

HDAC7

SOURCE GeneReport for Unigene cluster for HDAC7 Gene:

Hs.200063

Evidence on tissue expression from TISSUES for HDAC7 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Intestine(4.4)
  • Blood(2)
  • Lung(2)
  • Muscle(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with HDAC7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDAC7 Gene

Orthologs for HDAC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC7 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC7 34 33
  • 90.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC7 34 33
  • 90.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac7 16 34 33
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Hdac7 33
  • 86.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC7 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDAC7 34 33
  • 70.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC7 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac7 33
  • 63.57 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798603 33
  • 67.94 (n)
HDAC7 34
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HDAC4 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hda-4 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 34
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
ManyToMany
CSA.5129 34
  • 21 (a)
ManyToMany
Species where no ortholog for HDAC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC7 Gene

ENSEMBL:
Gene Tree for HDAC7 (if available)
TreeFam:
Gene Tree for HDAC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDAC7: view image

Paralogs for HDAC7 Gene

Paralogs for HDAC7 Gene

(8) SIMAP similar genes for HDAC7 Gene using alignment to 19 proteins:

  • HDAC7_HUMAN
  • C9J102_HUMAN
  • C9JAH2_HUMAN
  • C9JBC2_HUMAN
  • C9JEB6_HUMAN
  • C9JF80_HUMAN
  • C9JGF5_HUMAN
  • C9JH46_HUMAN
  • C9JKN3_HUMAN
  • C9JNI4_HUMAN
  • C9JS90_HUMAN
  • C9JVZ1_HUMAN
  • C9JZ79_HUMAN
  • F8VWY3_HUMAN
  • H0YH91_HUMAN
  • H0YHJ5_HUMAN
  • H0YI15_HUMAN
  • H0YI41_HUMAN
  • J3KPH8_HUMAN
genes like me logo Genes that share paralogs with HDAC7: view

Variants for HDAC7 Gene

Sequence variations from dbSNP and Humsavar for HDAC7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_036043 A breast cancer sample p.Val43Met
rs1000034370 -- 47,822,044(-) C/T upstream_transcript_variant
rs1000045649 -- 47,801,540(-) G/A intron_variant
rs1000051132 -- 47,815,061(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000142546 -- 47,797,595(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC7 Gene

Variant ID Type Subtype PubMed ID
dgv94n21 CNV loss 19592680
esv999028 CNV deletion 20482838
nsv1069661 CNV deletion 25765185
nsv1126315 CNV deletion 24896259
nsv470289 CNV gain 18288195

Variation tolerance for HDAC7 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDAC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC7 Gene

Disorders for HDAC7 Gene

Additional Disease Information for HDAC7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HDAC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HDAC7 Gene

Publications for HDAC7 Gene

  1. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. (PMID: 17962809) von Blume J … Seufferlein T (The EMBO journal 2007) 3 4 22 58
  2. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (PMID: 11466315) Fischle W … Verdin E (The Journal of biological chemistry 2001) 3 4 22 58
  3. β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. (PMID: 22155184) Satow R … Yamada T (Gastroenterology 2012) 3 4 58
  4. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. (PMID: 20188095) Harrison BC … McKinsey TA (FEBS letters 2010) 3 4 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for HDAC7 Gene

Sources for HDAC7 Gene