Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HDAC6 Gene

Aliases for HDAC6 Gene

  • Histone Deacetylase 6 2 3 3 5
  • Protein Phosphatase 1, Regulatory Subunit 90 2 3
  • HD6 3 4
  • EC 3.5.1.98 4
  • KIAA0901 4
  • PPP1R90 3
  • CPBHM 3
  • JM21 3

External Ids for HDAC6 Gene

Previous GeneCards Identifiers for HDAC6 Gene

  • GC0XP047463
  • GC0XP046921
  • GC0XP047706
  • GC0XP048416
  • GC0XP048545
  • GC0XP048659
  • GC0XP046319

Summaries for HDAC6 Gene

Entrez Gene Summary for HDAC6 Gene

  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC6 Gene

HDAC6 (Histone Deacetylase 6) is a Protein Coding gene. Diseases associated with HDAC6 include Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia and Alexander Disease. Among its related pathways are Notch signaling pathway (KEGG) and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin protein ligase binding. An important paralog of this gene is HDAC4.

UniProtKB/Swiss-Prot for HDAC6 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

  • In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Tocris Summary for HDAC6 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC6 Gene

Additional gene information for HDAC6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC6 Gene

Genomics for HDAC6 Gene

GeneHancer (GH) Regulatory Elements for HDAC6 Gene

Promoters and enhancers for HDAC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ048799 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 132 4 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 HDAC6 CCDC22 PRICKLE3 ENSG00000270012 ERAS ENSG00000204620 ZNF81 PLP2 FTSJ1 RBM3
GH0XJ048896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 +96.7 96651 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B PQBP1 TIMM17B FTSJ1 ENSG00000204620 ENSG00000270012 ZNF182 HDAC6 RBM3 CCDC22 PLP2
GH0XJ048573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 -226.4 -226391 3.4 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ENSG00000204620 RBM3 ZNF182 ENSG00000228343 FTSJ1 ZNF81 PRICKLE3 PQBP1 ENSG00000270012 HDAC6
GH0XJ049163 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +364.6 364609 5.6 HDGF PKNOX1 SMAD1 SIN3A ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 PLP2 ENSG00000279422 FTSJ1 ENSG00000204620 ENSG00000270012 HDAC6 CACNA1F GC0XP049169 MAGIX
GH0XJ048538 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 -261.5 -261468 3.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B TBC1D25 ENSG00000204620 RBM3 PORCN LOC101927635 FTSJ1 RN7SL262P ZNF630 ENSG00000228343 ZNF182
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HDAC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HDAC6 gene promoter:
  • AML1a
  • p300

Genomic Locations for HDAC6 Gene

Genomic Locations for HDAC6 Gene
chrX:48,801,377-48,824,982
(GRCh38/hg38)
Size:
23,606 bases
Orientation:
Plus strand
chrX:48,659,784-48,683,392
(GRCh37/hg19)
Size:
23,609 bases
Orientation:
Plus strand

Genomic View for HDAC6 Gene

Genes around HDAC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC6 Gene

Proteins for HDAC6 Gene

  • Protein details for HDAC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBN7-HDAC6_HUMAN
    Recommended name:
    Histone deacetylase 6
    Protein Accession:
    Q9UBN7
    Secondary Accessions:
    • O94975
    • Q6NT75
    • Q7L3E5
    • Q96CY0

    Protein attributes for HDAC6 Gene

    Size:
    1215 amino acids
    Molecular mass:
    131419 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with ZMYND15 (By similarity). Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with BBIP10, CBFA2T3, CYLD, DDIT3/CHOP, F-actin and HDAC11. Interacts with RIPOR2; this interaction occurs during early myogenic differentiation and prevents HDAC6 to deacetylate tubulin (PubMed:24687993). Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993).
    SequenceCaution:
    • Sequence=BAA74924.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HDAC6 Gene

    Alternative splice isoforms for HDAC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC6 Gene

Post-translational modifications for HDAC6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HDAC6

No data available for DME Specific Peptides for HDAC6 Gene

Domains & Families for HDAC6 Gene

Gene Families for HDAC6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HDAC6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBN7

UniProtKB/Swiss-Prot:

HDAC6_HUMAN :
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC6: view

Function for HDAC6 Gene

Molecular function for HDAC6 Gene

UniProtKB/Swiss-Prot Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
UniProtKB/Swiss-Prot Function:
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Enzyme Numbers (IUBMB) for HDAC6 Gene

Phenotypes From GWAS Catalog for HDAC6 Gene

Gene Ontology (GO) - Molecular Function for HDAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 24413532
GO:0003779 actin binding IEA --
GO:0004407 histone deacetylase activity IMP,IEA 23322205
GO:0005515 protein binding IPI 12024216
GO:0008013 beta-catenin binding IPI 18356165
genes like me logo Genes that share ontologies with HDAC6: view
genes like me logo Genes that share phenotypes with HDAC6: view

Human Phenotype Ontology for HDAC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HDAC6 Gene

MGI Knock Outs for HDAC6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC6

Clone Products

  • Addgene plasmids for HDAC6

No data available for Transcription Factor Targets and HOMER Transcription for HDAC6 Gene

Localization for HDAC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC6 Gene

Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
endosome 4
mitochondrion 2
endoplasmic reticulum 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HDAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11948178
GO:0005634 nucleus ISS,IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 19457097
GO:0005771 multivesicular body TAS 25548531
genes like me logo Genes that share ontologies with HDAC6: view

Pathways & Interactions for HDAC6 Gene

genes like me logo Genes that share pathways with HDAC6: view

SIGNOR curated interactions for HDAC6 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HDAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006476 protein deacetylation TAS 28386764
genes like me logo Genes that share ontologies with HDAC6: view

Drugs & Compounds for HDAC6 Gene

(60) Drugs for HDAC6 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Inhibitor, Target Histone deacetylase (HDAC)inhibitors 42
Bufexamac Approved, Experimental Pharma Target, inhibitor 0
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor, Target Histone deacetylase (HDAC)inhibitors 136
Romidepsin Approved, Investigational Pharma inhibitor, Target Histone deacetylase (HDAC)inhibitors 89
Vorinostat Approved, Investigational Pharma inhibitor, Target HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 254

(6) Additional Compounds for HDAC6 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Valproic acid, sodium salt
1069-66-5

(3) Tocris Compounds for HDAC6 Gene

Compound Action Cas Number
Apicidin Potent histone deacetylase inhibitor 183506-66-3
PCI 34051 Potent and selective HDAC8 inhibitor 950762-95-5
Valproic acid, sodium salt Histone deacetylase inhibitor 1069-66-5

(29) ApexBio Compounds for HDAC6 Gene

Compound Action Cas Number
ACY-241 Selective and orally active HDAC6 inhibitor 1316215-12-9
Apicidin Potent HDAC inhibitor 183506-66-3
AR-42 (OSU-HDAC42) HDAC inhibitor,novel and potent 935881-37-1
Belinostat (PXD101) Hydroxamate-type HDAC inhibitor 414864-00-9
BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective 445430-58-0
CUDC-101 Multitargeted HDAC inhibitor 1012054-59-9
Droxinostat Selective HDAC inhibitor 99873-43-5
HPOB HDAC6 inhibitor, potent and selective 1429651-50-2
ITF2357 (Givinostat) HDAC inhibitor 732302-99-7
KD 5170 HDAC inhibitor 940943-37-3
LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel 404951-53-7
M344 HDAC inhibitor,potent and cell-permeable 251456-60-7
MC1568 Class II HDAC inhibitor,potent and 852475-26-4
Nexturastat A HDAC6 inhibitor,highly potent and selective 1403783-31-2
Panobinostat (LBH589) HDAC inhibitor 404950-80-7
Parthenolide 20554-84-1
PCI-24781 (CRA-024781) Pan-HDAC inhibitor 783355-60-2
Resminostat (RAS2410) Potent HDAC inhibitor 864814-88-0
Resminostat hydrochloride HDAC inhibitor 1187075-34-8
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor 1316214-52-4
Santacruzamate A (CAY10683) 1477949-42-0
Sodium Phenylbutyrate Histone deacetylase inhibitor 1716-12-7
TCS HDAC6 20b Selective HDAC6 inhibitor 956154-63-5
Trichostatin A (TSA) HDAC inhibitor 58880-19-6
Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable 1350555-93-9
Tubastatin A HDAC6 inhibitor,potent and selective 1252003-15-8
Tubastatin A HCl HDAC6 inhibitor,potent and selective 1310693-92-5
Valproic acid sodium salt (Sodium valproate) HDAC inhibitor 1069-66-5
Vorinostat (SAHA, MK0683) HDAC inhibitor 149647-78-9
genes like me logo Genes that share compounds with HDAC6: view

Drug Products

Transcripts for HDAC6 Gene

Unigene Clusters for HDAC6 Gene

Histone deacetylase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC6

Clone Products

  • Addgene plasmids for HDAC6

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14: - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - -

ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5:
SP6:
SP7: - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - -
SP12:
SP13:
SP14:
SP15: -
SP16: -
SP17: - -
SP18:
SP19: - - - - - -
SP20:
SP21:
SP22:

ExUns: 27e ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b · 30c ^ 31 ^ 32 ^ 33a · 33b ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for HDAC6 Gene

GeneLoc Exon Structure for
HDAC6
ECgene alternative splicing isoforms for
HDAC6

Expression for HDAC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HDAC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HDAC6 Gene

This gene is overexpressed in Liver (7.7), Peripheral blood mononuclear cells (6.6), and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HDAC6 Gene



Protein tissue co-expression partners for HDAC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HDAC6 Gene:

HDAC6

SOURCE GeneReport for Unigene cluster for HDAC6 Gene:

Hs.6764

Evidence on tissue expression from TISSUES for HDAC6 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Kidney(2.4)
  • Lung(2.3)
  • Intestine(2.2)
  • Blood(2.1)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HDAC6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • ear
  • eye
  • face
  • forehead
  • head
  • meninges
  • nose
  • outer ear
  • skull
Thorax:
  • chest wall
  • rib
  • rib cage
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • femur
  • finger
  • foot
  • hand
  • hip
  • humerus
  • lower limb
  • thigh
  • toe
  • upper limb
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with HDAC6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HDAC6 Gene

Orthologs for HDAC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC6 34 33
  • 99.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC6 34 33
  • 84.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC6 34 33
  • 81.76 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac6 16 34 33
  • 81.38 (n)
rat
(Rattus norvegicus)
Mammalia Hdac6 33
  • 80.87 (n)
oppossum
(Monodelphis domestica)
Mammalia HDAC6 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HDAC6 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac6 33
  • 57.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia hdac6-prov 33
zebrafish
(Danio rerio)
Actinopterygii hdac6 34 33
  • 58.06 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HDAC6 35 33
  • 52.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000532 33
  • 35.58 (n)
worm
(Caenorhabditis elegans)
Secernentea hda-6 33
  • 48.34 (n)
Y51H1A.5 35
  • 40 (a)
F41H10.6b 35
  • 39 (a)
F41H10.6a 35
  • 38 (a)
F43G6.4 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 36 34
  • 25 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1597 33
corn
(Zea mays)
Liliopsida Zm.2498 33
Species where no ortholog for HDAC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HDAC6 Gene

ENSEMBL:
Gene Tree for HDAC6 (if available)
TreeFam:
Gene Tree for HDAC6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDAC6: view image

Paralogs for HDAC6 Gene

Paralogs for HDAC6 Gene

(8) SIMAP similar genes for HDAC6 Gene using alignment to 11 proteins:

  • HDAC6_HUMAN
  • A6NDI8_HUMAN
  • B4DZH6_HUMAN
  • C9J172_HUMAN
  • C9JEF4_HUMAN
  • E7EP63_HUMAN
  • E7EPS2_HUMAN
  • E7ER52_HUMAN
  • E7EUZ1_HUMAN
  • E9PEH1_HUMAN
  • H7C0Z9_HUMAN
genes like me logo Genes that share paralogs with HDAC6: view

Variants for HDAC6 Gene

Sequence variations from dbSNP and Humsavar for HDAC6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs398122390 pathogenic, Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia 48,824,894(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs782506012 uncertain-significance, Abnormality of neuronal migration 48,816,185(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs148220149 likely-benign, not provided 48,823,187(+) G/C coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs367767249 likely-benign, not provided 48,823,531(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs41312114 likely-benign, not provided 48,823,730(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC6 Gene

Variant ID Type Subtype PubMed ID
nsv6893 CNV insertion 18451855
nsv528292 CNV gain 19592680
esv3576862 CNV gain 25503493
esv32909 CNV gain+loss 17666407

Variation tolerance for HDAC6 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDAC6 Gene

Human Gene Mutation Database (HGMD)
HDAC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC6 Gene

Disorders for HDAC6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HDAC6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia
  • x-linked dominant chondrodysplasia, chassaing-lacombe type
alexander disease
  • alxdrd
brachydactyly
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards
Search HDAC6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HDAC6_HUMAN
  • Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. {ECO:0000269 PubMed:20181727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HDAC6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HDAC6: view

No data available for Genatlas for HDAC6 Gene

Publications for HDAC6 Gene

  1. Three proteins define a class of human histone deacetylases related to yeast Hda1p. (PMID: 10220385) Grozinger CM … Schreiber SL (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. (PMID: 19893491) Wickström SA … Massoumi R (The EMBO journal 2010) 3 4 22 58
  3. Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation. (PMID: 20102703) Zhuang Y … Shan B (Biochemical and biophysical research communications 2010) 3 4 22 58
  4. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PMID: 19033385) Kalveram B … Groettrup M (Journal of cell science 2008) 3 4 22 58
  5. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. (PMID: 17516032) Nahhas F … Tainsky MA (Molecular and cellular biochemistry 2007) 3 4 22 58

Products for HDAC6 Gene

Sources for HDAC6 Gene