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This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Pulmonary Disease, Chronic Obstructive and Colon Adenoma. Among its related pathways are RNA Polymerase I Promoter Escape and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HDAC1.
Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | 22926524 |
GO:0003682 | chromatin binding | ISS | -- |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0004407 | histone deacetylase activity | IEA,IDA | 16642021 |
GO:0005515 | protein binding | IPI | 9150135 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000118 | histone deacetylase complex | IBA | 21873635 |
GO:0000785 | chromatin | HDA | 16217013 |
GO:0005634 | nucleus | IEA,IDA | 18347167 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | TAS | 12711221 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
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2 | Signaling by NOTCH1 | ||
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
5 | Cell cycle |
.58
|
.58
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19041327 |
GO:0001975 | response to amphetamine | IEA | -- |
GO:0003300 | cardiac muscle hypertrophy | IEA | -- |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006338 | chromatin remodeling | IC | 17827154 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vorinostat | Approved, Investigational | Pharma | Target, inhibitor | HDAC inhibitor, Histone deacetylase (HDAC)inhibitors | 268 | |
Romidepsin | Approved, Investigational | Pharma | Target, antagonist, inhibitor | Histone deacetylase (HDAC)inhibitors | 101 | |
Valproic acid | Approved, Investigational | Pharma | Target, inhibitor | HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors | 387 | |
Belinostat | Approved, Investigational | Pharma | Target, inhibitor | Histone deacetylase (HDAC)inhibitors | 50 | |
Panobinostat | Approved, Investigational | Pharma | Target, inhibitor, Inhibition | Histone deacetylase (HDAC)inhibitors | 145 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Valproic acid, sodium salt |
|
1069-66-5 |
|
|
Compound | Action | Cas Number |
---|---|---|
Apicidin | Potent histone deacetylase inhibitor | 183506-66-3 |
PCI 34051 | Potent and selective HDAC8 inhibitor | 950762-95-5 |
Valproic acid, sodium salt | Histone deacetylase inhibitor | 1069-66-5 |
Compound | Action | Cas Number |
---|---|---|
2-hexyl-4-Pentynoic Acid | Potent and robust HDACs inhibitor | 96017-59-3 |
4SC-202 | Class I HDAC inhibitor | 1186222-89-8 |
AR-42 (OSU-HDAC42) | HDAC inhibitor,novel and potent | 935881-37-1 |
Belinostat (PXD101) | Hydroxamate-type HDAC inhibitor | 414864-00-9 |
BML-210(CAY10433) | Novel HDAC inhibitor | 537034-17-6 |
BMS-345541(free base) | IKK-1/IKK-2 inhibitor,potent and selective | 445430-58-0 |
Chidamide | Novel HDAC inhibitor | 743420-02-2 |
CUDC-907 | Potent PI3K/HDAC inhibitor | 1339928-25-4 |
Droxinostat | Selective HDAC inhibitor | 99873-43-5 |
HDAC Set I | ||
HPOB | HDAC6 inhibitor, potent and selective | 1429651-50-2 |
ITF2357 (Givinostat) | HDAC inhibitor | 732302-99-7 |
JNJ-26481585 | Potent HDAC inhibitor | 875320-29-9 |
LAQ824 (NVP-LAQ824,Dacinostat) | HDAC inhibitor,potent and novel | 404951-53-7 |
M344 | HDAC inhibitor,potent and cell-permeable | 251456-60-7 |
Mocetinostat (MGCD0103, MG0103) | HDAC inhibitor,isotype-selective and potent | 726169-73-9 |
NCH 51 | Histone deacetylase (HDAC) inhibitor | 848354-66-5 |
NSC 3852 | HDAC inhibitor | 3565-26-2 |
Panobinostat (LBH589) | HDAC inhibitor | 404950-80-7 |
Parthenolide | 20554-84-1 | |
PCI-24781 (CRA-024781) | Pan-HDAC inhibitor | 783355-60-2 |
Romidepsin (FK228, depsipeptide) | HDAC1/HDAC2 inhibitor,potent and selective | 128517-07-7 |
Santacruzamate A (CAY10683) | 1477949-42-0 | |
Sodium Phenylbutyrate | Histone deacetylase inhibitor | 1716-12-7 |
TC-H 106 | HDAC inhibitor | 937039-45-7 |
Trichostatin A (TSA) | HDAC inhibitor | 58880-19-6 |
Tubacin | HDAC6 inhibitor,potent,selective,reversible,cell-permeable | 1350555-93-9 |
UF 010 | Novel and selective class I HDAC inhibitor | 537672-41-6 |
Valproic acid sodium salt (Sodium valproate) | HDAC inhibitor | 1069-66-5 |
Vorinostat (SAHA, MK0683) | HDAC inhibitor | 149647-78-9 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | HDAC2 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | HDAC2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HDAC2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HDAC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HDAC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hdac2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hdac2 30 |
|
||
Chicken (Gallus gallus) |
Aves | HDAC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HDAC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hdac2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.25023 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hdac1 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rpd3 31 32 |
|
OneToMany | |
HDAC3 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | hda-1 30 31 32 |
|
ManyToMany | |
hda-3 31 |
|
ManyToMany | |||
hda-2 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPD3 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HDA6 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.11399 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os08g0344100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10476 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3554 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
977282 | Uncertain Significance: not specified | 113,956,687(-) |
A/G NM_001527.4(HDAC2):c.290T>C (p.Val97Ala) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
992209 | Uncertain Significance: not specified | 113,956,654(-) |
A/G NM_001527.4(HDAC2):c.323T>C (p.Phe108Ser) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
rs114260386 | Benign: not provided | 113,960,025(-) |
T/C NM_001527.4(HDAC2):c.53-7A>G |
INTRON | |
rs1554198179 | Uncertain Significance: Inborn genetic diseases | 113,959,978(-) |
C/T NM_001527.4(HDAC2):c.93G>A (p.Met31Ile) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
rs1582482024 | Likely Benign: not provided | 113,948,991(-) |
G/A NM_001527.4(HDAC2):c.829C>T (p.Leu277=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
pulmonary disease, chronic obstructive |
|
|
colon adenoma |
|
|
endometrial stromal sarcoma |
|
|
lung disease |
|
|
rett syndrome |
|
|