External Ids for HDAC11 Gene
Previous GeneCards Identifiers for HDAC11 Gene
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
GeneCards Summary for HDAC11 Gene
HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Bicipital Tenosynovitis and Subungual Glomus Tumor. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include hydrolase activity and histone deacetylase activity. An important paralog of this gene is HDAC1.
UniProtKB/Swiss-Prot Summary for HDAC11 Gene
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.