The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding d... See more...

Aliases for HDAC10 Gene

Aliases for HDAC10 Gene

  • Histone Deacetylase 10 2 3 4 5
  • Polyamine Deacetylase HDAC10 3 4
  • HD10 3 4
  • EC 3.5.1.48 4
  • EC 3.5.1.62 4

External Ids for HDAC10 Gene

Previous GeneCards Identifiers for HDAC10 Gene

  • GC22M047235
  • GC22M048865
  • GC22M048986
  • GC22M049025
  • GC22M050683
  • GC22M033581

Summaries for HDAC10 Gene

Entrez Gene Summary for HDAC10 Gene

  • The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HDAC10 Gene

HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Diseases associated with HDAC10 include Neuroblastoma. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC6.

UniProtKB/Swiss-Prot Summary for HDAC10 Gene

  • Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).

Tocris Summary for HDAC10 Gene

  • Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.

Gene Wiki entry for HDAC10 Gene

Additional gene information for HDAC10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HDAC10 Gene

Genomics for HDAC10 Gene

GeneHancer (GH) Regulatory Elements for HDAC10 Gene

Promoters and enhancers for HDAC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HDAC10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HDAC10

Top Transcription factor binding sites by QIAGEN in the HDAC10 gene promoter:
  • CUTL1
  • NF-kappaB
  • NF-kappaB1
  • Pax-2
  • Pax-4a
  • STAT3
  • USF2

Genomic Locations for HDAC10 Gene

Genomic Locations for HDAC10 Gene
chr22:50,245,183-50,251,405
(GRCh38/hg38)
Size:
6,223 bases
Orientation:
Minus strand
chr22:50,683,612-50,689,834
(GRCh37/hg19)
Size:
6,223 bases
Orientation:
Minus strand

Genomic View for HDAC10 Gene

Genes around HDAC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HDAC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HDAC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC10 Gene

Proteins for HDAC10 Gene

  • Protein details for HDAC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S8-HDA10_HUMAN
    Recommended name:
    Polyamine deacetylase HDAC10
    Protein Accession:
    Q969S8
    Secondary Accessions:
    • Q08AP4
    • Q6STF9
    • Q96P77
    • Q96P78
    • Q9H028
    • Q9UGX1
    • Q9UGX2

    Protein attributes for HDAC10 Gene

    Size:
    669 amino acids
    Molecular mass:
    71445 Da
    Quaternary structure:
    • Interacts with HDAC3 (PubMed:11861901). Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383). Interacts with HSPA8/HSC70 (PubMed:23801752). Interacts with MSH2 (PubMed:26221039).
    Miscellaneous:
    • Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA).
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for HDAC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HDAC10 Gene

Post-translational modifications for HDAC10 Gene

  • Ubiquitination at Lys80
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HDAC10 Gene

Domains & Families for HDAC10 Gene

Gene Families for HDAC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HDAC10 Gene

Blocks:
  • Histone deacetylase superfamily signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HDAC10 Gene

GenScript: Design optimal peptide antigens:
  • Histone deacetylase 10 (HDA10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969S8

UniProtKB/Swiss-Prot:

HDA10_HUMAN :
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
Family:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.
genes like me logo Genes that share domains with HDAC10: view

Function for HDAC10 Gene

Molecular function for HDAC10 Gene

UniProtKB/Swiss-Prot Function:
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(8)-acetylspermidine = acetate + spermidine; Xref=Rhea:RHEA:23928, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57834, ChEBI:CHEBI:58535; EC=3.5.1.48; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-acetylputrescine = acetate + putrescine; Xref=Rhea:RHEA:23412, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58263, ChEBI:CHEBI:326268; EC=3.5.1.62; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-acetylcadaverine = acetate + cadaverine; Xref=Rhea:RHEA:51892, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:58384, ChEBI:CHEBI:134408; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence={ECO:0000269 PubMed:11677242, ECO:0000269 PubMed:11726666, ECO:0000269 PubMed:11739383, ECO:0000269 PubMed:11861901, ECO:0000269 PubMed:26221039};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=110 uM for acetylcadaverine {ECO:0000269 PubMed:28516954}; KM=170 uM for acetylputrescine {ECO:0000269 PubMed:28516954}; KM=100 uM for N(8)-acetylspermidine {ECO:0000269 PubMed:28516954}; KM=180 uM for N(1)-acetylspermine {ECO:0000269 PubMed:28516954}; KM=150 uM for N(1),N(8)-diacetylspermidine {ECO:0000269 PubMed:28516954};

Enzyme Numbers (IUBMB) for HDAC10 Gene

Phenotypes From GWAS Catalog for HDAC10 Gene

Gene Ontology (GO) - Molecular Function for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 17172643
GO:0008270 zinc ion binding ISS --
GO:0016787 hydrolase activity IEA --
GO:0019213 deacetylase activity IDA 28516954
genes like me logo Genes that share ontologies with HDAC10: view
genes like me logo Genes that share phenotypes with HDAC10: view

Animal Models for HDAC10 Gene

MGI Knock Outs for HDAC10:
  • Hdac10 Hdac10<tm1.1(KOMP)Mbp>

Animal Model Products

CRISPR Products

miRNA for HDAC10 Gene

miRTarBase miRNAs that target HDAC10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC10

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HDAC10 Gene

Localization for HDAC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC10 Gene

Cytoplasm. Nucleus. Note=Excluded from nucleoli. {ECO:0000269 PubMed:11726666}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HDAC10 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 11861901
GO:0005634 nucleus IEA,IDA 11861901
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 11726666
genes like me logo Genes that share ontologies with HDAC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HDAC10 Gene

Pathways & Interactions for HDAC10 Gene

genes like me logo Genes that share pathways with HDAC10: view

Pathways by source for HDAC10 Gene

2 KEGG pathways for HDAC10 Gene
15 Qiagen pathways for HDAC10 Gene
  • BRCA1 Pathway
  • Cyclins and Cell Cycle Regulation
  • DNA Methylation and Transcriptional Repression
  • Estrogen Pathway
  • G1-S Phase Transition
2 GeneTex pathways for HDAC10 Gene

Gene Ontology (GO) - Biological Process for HDAC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11726666
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006325 chromatin organization NAS 11861901
GO:0006355 regulation of transcription, DNA-templated IDA 11861901
genes like me logo Genes that share ontologies with HDAC10: view

No data available for SIGNOR curated interactions for HDAC10 Gene

Drugs & Compounds for HDAC10 Gene

(23) Drugs for HDAC10 Gene - From: DrugBank, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Belinostat Approved, Investigational Pharma Target, inhibitor Histone deacetylase (HDAC)inhibitors 45
Bufexamac Approved, Withdrawn Pharma Target, inhibitor 0
Panobinostat Approved, Investigational Pharma Target, inhibitor, Inhibition Histone deacetylase (HDAC)inhibitors 142
Romidepsin Approved, Investigational Pharma inhibitor Histone deacetylase (HDAC)inhibitors 97
Vorinostat Approved, Investigational Pharma inhibitor HDAC inhibitor, Histone deacetylase (HDAC)inhibitors 264

(1) Additional Compounds for HDAC10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Valproic acid, sodium salt
1069-66-5

(3) Tocris Compounds for HDAC10 Gene

Compound Action Cas Number
Apicidin Potent histone deacetylase inhibitor 183506-66-3
PCI 34051 Potent and selective HDAC8 inhibitor 950762-95-5
Valproic acid, sodium salt Histone deacetylase inhibitor 1069-66-5

(6) ApexBio Compounds for HDAC10 Gene

Compound Action Cas Number
Chidamide Novel HDAC inhibitor 743420-02-2
CUDC-907 Potent PI3K/HDAC inhibitor 1339928-25-4
JNJ-26481585 Potent HDAC inhibitor 875320-29-9
MC1568 Class II HDAC inhibitor,potent and 852475-26-4
PCI-24781 (CRA-024781) Pan-HDAC inhibitor 783355-60-2
Pracinostat (SB939) Pan-HDAC inhibitor 929016-96-6
genes like me logo Genes that share compounds with HDAC10: view

Transcripts for HDAC10 Gene

mRNA/cDNA for HDAC10 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HDAC10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: -
SP15: - - - - - -
SP16: - - - - - - - -
SP17: - - -
SP18:
SP19:
SP20: - - -
SP21: - - - - - -
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:

ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: -
SP7: - - - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - - -
SP15:
SP16:
SP17: - - - - -
SP18: - -
SP19: -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HDAC10 Gene

GeneLoc Exon Structure for
HDAC10

Expression for HDAC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HDAC10 Gene

Protein differential expression in normal tissues from HIPED for HDAC10 Gene

This gene is overexpressed in Lung (39.5), Heart (13.1), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HDAC10 Gene



Protein tissue co-expression partners for HDAC10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HDAC10

SOURCE GeneReport for Unigene cluster for HDAC10 Gene:

Hs.26593

mRNA Expression by UniProt/SwissProt for HDAC10 Gene:

Q969S8-HDA10_HUMAN
Tissue specificity: Widely expressed with high levels in liver and kidney.

Evidence on tissue expression from TISSUES for HDAC10 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with HDAC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HDAC10 Gene

Orthologs for HDAC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HDAC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC10 31 30
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC10 31 30
  • 82.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC10 31 30
  • 82.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hdac10 17 31 30
  • 78.03 (n)
rat
(Rattus norvegicus)
Mammalia Hdac10 30
  • 76.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HDAC10 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves HDAC10 31 30
  • 53.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC10 31
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac10 30
  • 52.5 (n)
zebrafish
(Danio rerio)
Actinopterygii hdac10 31 30
  • 54.96 (n)
OneToOne
wufd19e10 30
fruit fly
(Drosophila melanogaster)
Insecta HDAC6 31
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y51H1A.5 32
  • 41 (a)
F43G6.4 32
  • 33 (a)
hda-10 31
  • 29 (a)
OneToMany
hda-5 31
  • 27 (a)
OneToMany
F43G6.17 31
  • 23 (a)
OneToMany
hda-6 31
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HDA1 31
  • 22 (a)
OneToMany
Species where no ortholog for HDAC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HDAC10 Gene

ENSEMBL:
Gene Tree for HDAC10 (if available)
TreeFam:
Gene Tree for HDAC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HDAC10: view image

Paralogs for HDAC10 Gene

(3) SIMAP similar genes for HDAC10 Gene using alignment to 3 proteins:

  • HDA10_HUMAN
  • C9J8B8_HUMAN
  • Q08AP5_HUMAN
genes like me logo Genes that share paralogs with HDAC10: view

Variants for HDAC10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HDAC10 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs34402301 - p.Val429Ile

Additional dbSNP identifiers (rs#s) for HDAC10 Gene

Structural Variations from Database of Genomic Variants (DGV) for HDAC10 Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv1066496 CNV loss 25217958
nsv471223 CNV loss 18288195
nsv955199 CNV deletion 24416366

Variation tolerance for HDAC10 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HDAC10 Gene

Human Gene Mutation Database (HGMD)
HDAC10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HDAC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HDAC10 Gene

Disorders for HDAC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HDAC10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • nb
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HDA10_HUMAN
  • Note=In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752). {ECO:0000269 PubMed:23801752, ECO:0000269 PubMed:29968769, ECO:0000303 PubMed:23801752}.

Additional Disease Information for HDAC10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HDAC10: view

No data available for Genatlas for HDAC10 Gene

Publications for HDAC10 Gene

  1. Molecular cloning and characterization of a novel histone deacetylase HDAC10. (PMID: 11726666) Guardiola AR … Yao TP (The Journal of biological chemistry 2002) 2 3 4 23 54
  2. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (PMID: 11677242) Kao HY … Evans RM (The Journal of biological chemistry 2002) 2 3 4 23 54
  3. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. (PMID: 11861901) Tong JJ … Yang XJ (Nucleic acids research 2002) 3 4 23 54
  4. Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance. (PMID: 29968769) Ridinger J … Oehme I (Scientific reports 2018) 3 4 54
  5. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. (PMID: 28516954) Hai Y … Christianson DW (Nature communications 2017) 3 4 54

Products for HDAC10 Gene

Sources for HDAC10 Gene