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The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009] See more...
Aliases for HCRTR2 Gene
Aliases for HCRTR2 Gene
External Ids for HCRTR2 Gene
- HGNC: 4849
- Entrez Gene: 3062
- Ensembl: ENSG00000137252
- OMIM: 602393
- UniProtKB: O43614
Previous GeneCards Identifiers for HCRTR2 Gene
- GC06P055041
- GC06P055085
- GC06P055147
- GC06P054873
Summaries for HCRTR2 Gene
-
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
GeneCards Summary for HCRTR2 Gene
HCRTR2 (Hypocretin Receptor 2) is a Protein Coding gene. Diseases associated with HCRTR2 include Cluster Headache and Narcolepsy. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is HCRTR1.
UniProtKB/Swiss-Prot Summary for HCRTR2 Gene
-
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
-
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness.
Additional gene information for HCRTR2 Gene
- HGNC(4849)
- Entrez Gene(3062)
- Ensembl(ENSG00000137252)
- OMIM(602393)
- UniProtKB(O43614)
- Open Targets Platform(ENSG00000137252)
- Monarch Initiative
- Search for HCRTR2 at DataMed
- Search for HCRTR2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCRTR2 Gene
Genomics for HCRTR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HCRTR2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J055039 | Promoter/Enhancer | 0.9 | EPDnew FANTOM5 ENCODE | 600.2 | -66.1 | -66147 | 0.3 | CEBPB FOS | HSALNG0050745 HCRTR2 ENSG00000224984 piR-33422-366 FAM83B | |
| GH06J055112 | Promoter | 0.3 | EPDnew | 600.4 | +6.0 | 6016 | 0.1 | HCRTR2 piR-60885-130 GFRAL | ||
| GH06J055106 | Enhancer | 0.3 | Ensembl | 600.7 | +0.5 | 541 | 0.4 | POLR2A | HCRTR2 ENSG00000224984 piR-60885-130 GFRAL | |
| GH06J054698 | Enhancer | 0.9 | Ensembl ENCODE | 9.6 | -407.3 | -407259 | 2.8 | BACH1 RELA IKZF2 RCOR1 CTCF DPF2 RELB CTBP1 PKNOX1 ZNF217 | HCRTR2 ENSG00000224984 ENSG00000261116 piR-33614-242 piR-38051-241 lnc-HMGCLL1-4 LOC107986606 FAM83B TINAG | |
| GH06J055047 | Enhancer | 0.7 | Ensembl ENCODE | 10.5 | -58.9 | -58859 | 3.2 | ZBTB20 ZNF10 NFE2 OSR2 PKNOX1 CUX1 SPI1 FOXA1 ZNF660 FOS | HCRTR2 ENSG00000224984 HSALNG0050745 piR-50937 FAM83B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HCRTR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCRTR2
- Top Transcription factor binding sites by QIAGEN in the HCRTR2 gene promoter:
-
- aMEF-2
- c-Myb
- Cart-1
- FOXI1
- HFH-3
- MEF-2
- SEF-1 (1)
- SRF
- SRF (504 AA)
- SRY
Genomic Locations for HCRTR2 Gene
Genomic Locations for HCRTR2 Gene
- chr6:55,106,460-55,284,698
- (GRCh38/hg38)
- Size:
- 178,239 bases
- Orientation:
- Plus strand
- chr6:55,039,050-55,147,418
- (GRCh37/hg19)
- Size:
- 108,369 bases
- Orientation:
- Plus strand
Genomic View for HCRTR2 Gene
Genes around HCRTR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
HCRTR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HCRTR2 Gene
Proteins for HCRTR2 Gene
-
Protein details for HCRTR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43614-OX2R_HUMAN
- Recommended name:
- Orexin receptor type 2
- Protein Accession:
- O43614
- Q5VTM0
Protein attributes for HCRTR2 Gene
- Size:
- 444 amino acids
- Molecular mass:
- 50694 Da
- Quaternary structure:
- No Data Available
Protein Expression for HCRTR2 Gene
Post-translational modifications for HCRTR2 Gene
Other Protein References for HCRTR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HCRTR2 Antibody
-
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-
Abcam antibodies for HCRTR2
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-
Biorbyt antibodies for HCRTR2
-
Boster Bio Antibodies for HCRTR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HCRTR2
Protein Products
-
OriGene Purified Proteins for HCRTR2
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-
Abcam proteins for HCRTR2
Assay Products
- G Biosciences Immunotag™ Orexin receptor type 2 ELISA Kit
- antibodies-online: Show 7 available HCRTR2 Elisa Kits ranked by validation data
- Compare Top HCRTR2 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for HCRTR2
No data available for DME Specific Peptides for HCRTR2 Gene
Domains & Families for HCRTR2 Gene
Gene Families for HCRTR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for HCRTR2 Gene
- InterPro:
- Blocks:
-
- Orexin receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for HCRTR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Hypocretin receptor type 2 (OX2R_HUMAN)
- cDNA, FLJ95033, Homo sapiens hypocretin (orexin) receptor 2 (HCRTR2), mRNA (Q548Y0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43614UniProtKB/Swiss-Prot:
OX2R_HUMAN :- The N-terminal region is required for orexin signaling.
- Belongs to the G-protein coupled receptor 1 family.
- Domain:
-
- The N-terminal region is required for orexin signaling.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for HCRTR2 Gene
Molecular function for HCRTR2 Gene
- UniProtKB/Swiss-Prot Function:
- Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
- GENATLAS Biochemistry:
- hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B
Phenotypes From GWAS Catalog for HCRTR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
| GO:0008188 | neuropeptide receptor activity | TAS | 9491897 |
| GO:0016499 | orexin receptor activity | IBA,IDA | 26950369 |
| GO:0017046 | peptide hormone binding | IEA | -- |
| GO:0042277 | peptide binding | IBA | -- |
Phenotypes for HCRTR2 Gene
- MGI mutant phenotypes for HCRTR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HCRTR2:
Animal Models for HCRTR2 Gene
- MGI Knock Outs for HCRTR2:
-
- Hcrtr2 Hcrtr2<tm1Ywa>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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miRNA for HCRTR2 Gene
- miRTarBase miRNAs that target HCRTR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRTR2
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Clone Products
- Applied Biological Materials (abm): Clones for HCRTR2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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Cell Line Products
-
Horizon Cell Lines for HCRTR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCRTR2 Gene
Localization for HCRTR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HCRTR2 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IDA | 26950369 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HCRTR2 Gene
Pathways & Interactions for HCRTR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Circadian rythm related genes | ||
Pathways by source for HCRTR2 Gene
2 BioSystems pathways for HCRTR2 Gene
9 Reactome pathways for HCRTR2 Gene
1 KEGG pathway for HCRTR2 Gene
Interacting Proteins for HCRTR2 Gene
GPS-Prot Interaction Network for HCRTR2
SIGNOR curated interactions for HCRTR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007218 | neuropeptide signaling pathway | IEA,IDA | 26950369 |
| GO:0007268 | chemical synaptic transmission | TAS | 9491897 |
Drugs & Compounds for HCRTR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Suvorexant | Approved, Investigational | Pharma | Antagonist, Target, antagonist | 43 | ||
| Lemborexant | Approved, Investigational | Pharma | Target, antagonist | 0 | ||
| Allopurinol | Approved | Pharma | 176 | |||
| Almorexant | Investigational | Pharma | antagonist | OX1R/OX2R antagonist | 0 | |
| SB-649868 | Investigational | Pharma | Antagonist, antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea |
|
Antagonist |
|
|||
| ACT-078573 |
|
Antagonist |
|
|||
| MK-6096 |
|
Antagonist |
|
|||
| N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide |
|
Antagonist |
|
|||
| IPSU |
|
1373765-19-5 |
|
|
(5) Tocris Compounds for HCRTR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ala11,D-Leu15]-Orexin B | Potent, selective OX2 receptor agonist | 532932-99-3 |
| EMPA | Highly potent and selective OX2 antagonist; brain penetrant | 680590-49-2 |
| IPSU | OX2 receptor antagonist; orally bioavailable | 1373765-19-5 |
| JNJ 10397049 | Selective OX2 receptor antagonist | 708275-58-5 |
| TCS OX2 29 | Potent and selective OX2 antagonist | 372523-75-6 |
(14) ApexBio Compounds for HCRTR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ala11,D-Leu15]-Orexin B | 532932-99-3 | |
| Allopurinol | 315-30-0 | |
| Almorexant | OX1R/OX2R antagonist | 871224-64-5 |
| Almorexant hydrochloride | OX1R/OX2R antagonist | 913358-93-7 |
| EMPA | 680590-49-2 | |
| JNJ 10397049 | 708275-58-5 | |
| Orexin A (human, rat, mouse) | 205640-90-0 | |
| Orexin B (human) | 205640-91-1 | |
| Orexin B (mouse) | 202801-92-1 | |
| OXA (17-33) | 343268-91-7 | |
| SB-334867 free base | 792173-99-0 | |
| SB408124 | OX(1)receptor antagonist | 288150-92-5 |
| TCS 1102 | 916141-36-1 | |
| TCS OX2 29 | 372523-75-6 |
Transcripts for HCRTR2 Gene
mRNA/cDNA for HCRTR2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370862 1837 nts (view in UCSC)
- ENST00000615358 1936 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HCRTR2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HCRTR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRTR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HCRTR2
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for HCRTR2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HCRTR2
- Addgene plasmids for HCRTR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRTR2
Relevant External Links for HCRTR2 Gene
- GeneLoc Exon Structure for
- HCRTR2
Expression for HCRTR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Epiblast (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HCRTR2 Gene
This gene is overexpressed in Brain - Hypothalamus (x9.4), Brain - Substantia nigra (x5.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HCRTR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCRTR2
SOURCE GeneReport for Unigene cluster for HCRTR2 Gene:
Hs.151624Evidence on tissue expression from TISSUES for HCRTR2 Gene
- Nervous system(2.6)
Primer Products
-
OriGene qPCR primer pairs for HCRTR2
-
OriGene qPCR primer pairs and template standards for HCRTR2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCRTR2 Gene
Orthologs for HCRTR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HCRTR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HCRTR2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HCRTR2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hcrtr2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hcrtr2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HCRTR2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HCRTR2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HCRTR2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hcrtr2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hcrtr2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | NepYr 32 |
|
|
|
| SIFR 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | npr-2 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for HCRTR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HCRTR2 Gene
- ENSEMBL:
- Gene Tree for HCRTR2 (if available)
- TreeFam:
- Gene Tree for HCRTR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HCRTR2: view image
Paralogs for HCRTR2 Gene
Paralogs for HCRTR2 Gene
(16) SIMAP similar genes for HCRTR2 Gene using alignment to 4 proteins:
- OX2R_HUMAN
- Q548Y0_HUMAN
- S4WX84_HUMAN
- S4X0W3_HUMAN
Variants for HCRTR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HCRTR2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714952 | Likely Benign: not provided | 55,282,411(+) | C/A | MISSENSE_VARIANT | |
| 728949 | Benign: not provided | 55,282,301(+) | C/T | SYNONYMOUS_VARIANT | |
| 768101 | Benign: not provided | 55,277,463(+) | G/A | SYNONYMOUS_VARIANT | |
| rs2653349 | - | p.Ile308Val | |||
| rs41271310 | - | p.Pro10Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1151776 | CNV | insertion | 26484159 |
Residual Variation Intolerance Score:
65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.24;
40.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HCRTR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRTR2 Gene
Disorders for HCRTR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cluster headache |
|
|
| narcolepsy |
|
|
| sleep disorder |
|
|
| rohhad |
|
|
| hematuria, benign familial |
|
|
Search HCRTR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HCRTR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HCRTR2 Gene
Publications for HCRTR2 Gene
- Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache. (PMID: 18399985) Rainero I … Pinessi L (Headache 2008) 3 23 41
- Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. (PMID: 17563843) Rainero I … Pinessi L (The journal of headache and pain 2007) 3 23 41
- The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. (PMID: 17376114) Schürks M … Rosskopf D (Cephalalgia : an international journal of headache 2007) 3 23 41
- Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene. (PMID: 17883525) Schürks M … Rosskopf D (Headache 2007) 3 23 41
- The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraine. (PMID: 17645762) Pinessi L … Vaula G (Cephalalgia : an international journal of headache 2007) 3 23 41
ExternalLinks
Products for HCRTR2 Gene
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HCRTR2
- Novus Biologicals proteins and lysates for HCRTR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HCRTR2
- Abcam proteins for HCRTR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for HCRTR2 (AFLGC-HCRTR2)
- ApexBio compounds for HCRTR2
- VectorBuilder Custom and pre-made DNA vectors for HCRTR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HCRTR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HCRTR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HCRTR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HCRTR2
- Addgene plasmids for HCRTR2
- antibodies-online: Show 73 available HCRTR2 Antibodies ranked by validation data
- Compare Top HCRTR2 Antibodies
- antibodies-online: Show 7 available HCRTR2 Elisa Kits ranked by validation data
- Compare Top HCRTR2 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available HCRTR2 Proteins ranked by validation data
- Compare Top HCRTR2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HCRTR2
- Search Santa Cruz Biotechnology (SCBT) for HCRTR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HCRTR2
- Horizon Cell Lines for HCRTR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRTR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRTR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HCRTR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRTR2
- Boster Bio Antibodies for HCRTR2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for HCRTR2
Sources for HCRTR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB