Aliases for HCRTR1 Gene
External Ids for HCRTR1 Gene
Previous GeneCards Identifiers for HCRTR1 Gene
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
GeneCards Summary for HCRTR1 Gene
HCRTR1 (Hypocretin Receptor 1) is a Protein Coding gene. Diseases associated with HCRTR1 include Narcolepsy and Rohhad. Among its related pathways are Signaling by GPCR and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is HCRTR2.
UniProtKB/Swiss-Prot Summary for HCRTR1 Gene
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate sleep-wakefulness and energy homeostasis, particularly food intake.