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This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
HCRT (Hypocretin Neuropeptide Precursor) is a Protein Coding gene. Diseases associated with HCRT include Narcolepsy 1 and Narcolepsy. Among its related pathways are Neuroscience and RET signaling. Gene Ontology (GO) annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005184 | neuropeptide hormone activity | IEA,IBA | 21873635 |
GO:0031771 | type 1 hypocretin receptor binding | IBA | 21873635 |
GO:0031772 | type 2 hypocretin receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005791 | rough endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Neuroscience |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001659 | temperature homeostasis | IBA | 21873635 |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
GO:0007205 | protein kinase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Pidolic acid | Approved, Investigational | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HCRT 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BORX 31 |
|
OneToOne | |
HCRT 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | HCRT 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hcrt 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hcrt 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HCRT 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HCRT 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HCRT 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | hcrt 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs104894574 | Pathogenic: Narcolepsy 1. Narcolepsy 1 (NRCLP1) [MIM:161400] | 42,184,503(-) | A/Cp.Leu16Arg | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1056904 | CNV | gain | 25217958 |
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
narcolepsy 1 |
|
|
narcolepsy |
|
|
sleep disorder |
|
|
recurrent hypersomnia |
|
|
narcolepsy 2 |
|
|