Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolis... See more...
Aliases for HCRT Gene
Aliases for HCRT Gene
External Ids for HCRT Gene
- HGNC: 4847
- NCBI Entrez Gene: 3060
- Ensembl: ENSG00000161610
- OMIM®: 602358
- UniProtKB/Swiss-Prot: O43612
Previous GeneCards Identifiers for HCRT Gene
- GC17M039901
- GC17M042492
- GC17M040244
- GC17M040709
- GC17M037589
- GC17M040337
- GC17M036101
Summaries for HCRT Gene
-
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
GeneCards Summary for HCRT Gene
HCRT (Hypocretin Neuropeptide Precursor) is a Protein Coding gene. Diseases associated with HCRT include Narcolepsy 1 and Narcolepsy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.
UniProtKB/Swiss-Prot Summary for HCRT Gene
-
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Additional gene information for HCRT Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCRT Gene
Genomics for HCRT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HCRT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HCRT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCRT
- Top Transcription factor binding sites by QIAGEN in the HCRT gene promoter:
-
- ARP-1
- CREB
- deltaCREB
- FOXJ2
- HOXA5
- ITF-2
- NRSF form 1
- NRSF form 2
- STAT3
- Tal-1beta
Genomic Locations for HCRT Gene
Latest Assembly
- chr17:42,184,060-42,185,452
- (GRCh38/hg38)
- Size:
- 1,393 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:40,336,078-40,337,470
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,393 bases
- Orientation:
- Minus strand
Genomic View for HCRT Gene
Genes around HCRT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by HGNC
- 17q21.2 by Entrez Gene
- 17q21.2 by Ensembl
HCRT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HCRT Gene
Proteins for HCRT Gene
-
Protein details for HCRT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43612-OREX_HUMAN
- Recommended name:
- Orexin
- Protein Accession:
- O43612
Protein attributes for HCRT Gene
- Size:
- 131 amino acids
- Molecular mass:
- 13363 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HCRT Gene
- Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Other Protein References for HCRT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences HCRT / Orexin Antibody
- RayBiotech Rabbit Anti-Human Orexin A, Rabbit Anti-Human Orexin B, and Rabbit anti-Orexin A
- GeneTex Anti-Orexin B antibody
- Novus Biologicals Antibodies for HCRT
- Invitrogen Antibodies for HCRT (AFLGC-HCRT)
-
Boster Bio Antibodies for HCRT
-
Santa Cruz Biotechnology (SCBT) Antibodies for HCRT
Protein products for research
-
OriGene Purified Proteins for HCRT
- Search Origene for MassSpec and Protein Over-expression Lysates for HCRT
- Origene Custom Protein Services for HCRT
- Novus Biologicals lysates for HCRT
Assay products for research
- Novus Biologicals ELISA Kits for HCRT
- antibodies-online: Show 46 available Hypocretin-2 Elisa Kits ranked by validation data
- Compare Top Hypocretin-2 Elisa Kits
-
Quality Products:
- ABIN1450253
- ABIN5521344
- ABIN2851413
- ABIN5592465
- ABIN456042
- ABIN5657511
- ABIN2537386
- ABIN4971727
- ABIN6199871
- ABIN2044133
- ABIN426178
- ABIN5521345
- ABIN2851414
- ABIN5592466
- ABIN5657512
- ABIN2537387
- ABIN4971728
- ABIN6199874
- ABIN2044135
- ABIN5072907
- ABIN5521346
- ABIN5608533
- ABIN5592467
- ABIN2950068
- ABIN5072908
- ABIN579817
- ABIN841466
- ABIN5608531
- ABIN1146491
No data available for DME Specific Peptides for HCRT Gene
Domains & Families for HCRT Gene
Gene Families for HCRT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted secreted proteins
Protein Domains for HCRT Gene
- InterPro:
- Blocks:
-
- Prepro-orexin signature
Suggested Antigen Peptide Sequences for HCRT Gene
- GenScript: Design optimal peptide antigens:
-
- Hypocretin (OREX_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43612- Family:
-
- Belongs to the orexin family.
Function for HCRT Gene
Molecular function for HCRT Gene
- UniProtKB/Swiss-Prot Function:
- Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
- GENATLAS Biochemistry:
- hypocretin neuropeptide precursor of isoforms A and B,expressed in lateral hypothalamus and adjacent areas,potential mediator in the central feedback mechanism,that regulates feeding behavior,homolog to secretin,susceptibility gene for narcolepsy
Phenotypes From GWAS Catalog for HCRT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005184 | neuropeptide hormone activity | IEA,IBA | 21873635 |
| GO:0031771 | type 1 hypocretin receptor binding | IBA | 21873635 |
| GO:0031772 | type 2 hypocretin receptor binding | IBA | 21873635 |
Phenotypes for HCRT Gene
- MGI mutant phenotypes for HCRT:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HCRT:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HCRT - Starting at $85 >
- * HCRT CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HCRT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
-
Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
miRNA for HCRT Gene
- miRTarBase miRNAs that target HCRT
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
- Browse OriGene Inhibitory RNA Products For HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
Clone products for research
- Applied Biological Materials (abm): Clones for HCRT - Starting at $45 >
- * HCRT as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HCRT
- Addgene plasmids for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
Cell Lines for research
-
Horizon Cell Lines for HCRT
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HCRT Gene
Localization for HCRT Gene
Subcellular locations from UniProtKB/Swiss-Prot for HCRT Gene
- Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005791 | rough endoplasmic reticulum | IEA | -- |
| GO:0008021 | synaptic vesicle | TAS | 9419374 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HCRT Gene
Pathways & Interactions for HCRT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Neuroscience | ||
Pathways by source for HCRT Gene
9 Reactome pathways for HCRT Gene
1 KEGG pathway for HCRT Gene
1 Cell Signaling Technology pathway for HCRT Gene
Interacting Proteins for HCRT Gene
GPS-Prot Interaction Network for HCRT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001659 | temperature homeostasis | IBA | 21873635 |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
| GO:0007205 | protein kinase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
Drugs & Compounds for HCRT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pidolic acid | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for HCRT Gene
mRNA/cDNA for HCRT Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000293330 577 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HCRT - Starting at $85 >
- * HCRT CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HCRT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
-
Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
- Browse OriGene Inhibitory RNA Products For HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
Clone products for research
- Applied Biological Materials (abm): Clones for HCRT - Starting at $45 >
- * HCRT as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HCRT
- Addgene plasmids for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
Relevant External Links for HCRT Gene
- GeneLoc Exon Structure for
- HCRT
Expression for HCRT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HCRT Gene
This gene is overexpressed in Brain - Hypothalamus (x51.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCRT
SOURCE GeneReport for Unigene cluster for HCRT Gene:
Hs.158348mRNA Expression by UniProt/SwissProt for HCRT Gene:
O43612-OREX_HUMAN
Tissue specificity:
Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for HCRT Gene
- Nervous system(3.5)
- Adrenal gland(2.8)
- Muscle(2.8)
- Heart(2.5)
- Pancreas(2.4)
- Thyroid gland(2.4)
- Skin(2.4)
- Blood(2.2)
- Stomach(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HCRT Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
- mouth
- pharynx
Thorax:
- heart
General:
- blood vessel
- peripheral nervous system
Primer products for research
-
OriGene qPCR primer pairs for HCRT
-
OriGene qPCR primer pairs and template standards for HCRT
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HCRT Gene
Orthologs for HCRT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HCRT 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BORX 30 |
|
OneToOne | |
| HCRT 29 |
|
||||
| Dog (Canis familiaris) |
Mammalia | HCRT 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hcrt 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hcrt 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HCRT 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HCRT 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HCRT 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | hcrt 30 |
|
OneToOne |
- Species where no ortholog for HCRT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HCRT Gene
- ENSEMBL:
- Gene Tree for HCRT (if available)
- TreeFam:
- Gene Tree for HCRT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HCRT: view image
- Alliance of Genome Resources:
- Additional Orthologs for HCRT
Paralogs for HCRT Gene
No data available for Paralogs for HCRT Gene
Variants for HCRT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HCRT Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894574 | Pathogenic: Narcolepsy 1. Narcolepsy 1 (NRCLP1) [MIM:161400] | 42,184,503(-) |
A/Cp.Leu16Arg NM_001524.1(HCRT):c.47T>G (p.Leu16Arg) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056904 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
Gene Damage Index Score:
0.73;
15.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HCRT Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRT Gene
Disorders for HCRT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| narcolepsy 1 |
|
|
| narcolepsy |
|
|
| recurrent hypersomnia |
|
|
| narcolepsy 2 |
|
|
| idiopathic hypersomnia |
|
|
Search HCRT in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
OREX_HUMAN- Narcolepsy 1 (NRCLP1) [MIM:161400]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:10973318}. Note=The disease is caused by variants affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.
Additional Disease Information for HCRT
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for HCRT Gene
Publications for HCRT Gene
- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. (PMID: 10973318) Peyron C … Mignot E (Nature medicine 2000) 3 4 22 72
- Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. (PMID: 16429482) Takai T … Ikegami T (Journal of peptide science : an official publication of the European Peptide Society 2006) 3 4 22
- Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. (PMID: 15978554) Meerabux J … Yoshikawa T (Biological psychiatry 2005) 3 22 40
- Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. (PMID: 10583376) Lee JH … Lee W (European journal of biochemistry 1999) 3 4 22
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PMID: 9491897) Sakurai T … Yanagisawa M (Cell 1998) 2 3 4
ExternalLinks
Products for HCRT Gene
- View all 3 R&D Systems HCRT (Orexin A/Hypocretin-1) Products
- View all 2 R&D Systems HCRT (Orexin B/Hypocretin-2) Products
- View all 2 R&D Systems HCRT (Orexin A/Hypocretin-1) Primary Antibodies
- View all R&D Systems HCRT (Orexin B/Hypocretin-2) Primary Antibodies
- View all R&D Systems HCRT (Orexin A/Hypocretin-1) Peptides
- View all R&D Systems HCRT (Orexin B/Hypocretin-2) Peptides
- Learn more about R&D Systems custom HCRT antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HCRT
- Search Origene for MassSpec and Protein Over-expression Lysates for HCRT
- Origene Custom Protein Services for HCRT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
- Browse OriGene Inhibitory RNA Products For HCRT
- OriGene qPCR primer pairs for HCRT
- OriGene qPCR primer pairs and template standards for HCRT
- OriGene CRISPR knockouts for HCRT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HCRT
- Sino Biological Human cDNA Clone for HCRT
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HCRT
- Novus Biologicals lysates for HCRT
- Novus Biologicals ELISA Kits for HCRT
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for HCRT (AFLGC-HCRT)
- VectorBuilder Custom and pre-made DNA vectors for HCRT (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HCRT (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HCRT (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HCRT CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HCRT
- Addgene plasmids for HCRT
- antibodies-online: Show 22 available Hypocretin-2 Antibodies ranked by validation data
- Compare Top Hypocretin-2 Antibodies
- antibodies-online: Show 46 available Hypocretin-2 Elisa Kits ranked by validation data
- Compare Top Hypocretin-2 Elisa Kits
- Quality Products:
- ABIN1450253
- ABIN5521344
- ABIN2851413
- ABIN5592465
- ABIN456042
- ABIN5657511
- ABIN2537386
- ABIN4971727
- ABIN6199871
- ABIN2044133
- ABIN426178
- ABIN5521345
- ABIN2851414
- ABIN5592466
- ABIN5657512
- ABIN2537387
- ABIN4971728
- ABIN6199874
- ABIN2044135
- ABIN5072907
- ABIN5521346
- ABIN5608533
- ABIN5592467
- ABIN2950068
- ABIN5072908
- ABIN579817
- ABIN841466
- ABIN5608531
- ABIN1146491
- antibodies-online: Show 3 available Hypocretin-2 Proteins ranked by validation data
- Compare Top Hypocretin-2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HCRT
- Search Santa Cruz Biotechnology (SCBT) for HCRT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
- Horizon Cell Lines for HCRT
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
- Boster Bio Antibodies for HCRT
- Browse Boster Bio ELISA Kits
Sources for HCRT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources