Aliases for HCRT Gene
Aliases for HCRT Gene
External Ids for HCRT Gene
- HGNC: 4847
- Entrez Gene: 3060
- Ensembl: ENSG00000161610
- OMIM: 602358
- UniProtKB: O43612
Previous GeneCards Identifiers for HCRT Gene
- GC17M039901
- GC17M042492
- GC17M040244
- GC17M040709
- GC17M037589
- GC17M040337
- GC17M036101
Summaries for HCRT Gene
-
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
GeneCards Summary for HCRT Gene
HCRT (Hypocretin Neuropeptide Precursor) is a Protein Coding gene. Diseases associated with HCRT include Narcolepsy 1 and Narcolepsy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.
UniProtKB/Swiss-Prot for HCRT Gene
-
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Additional gene information for HCRT Gene
- Monarch Initiative
- Search for HCRT at DataMed
- Search for HCRT at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRT Gene
Genomics for HCRT Gene
GeneHancer (GH) Regulatory Elements for HCRT Gene
Promoters and enhancers for HCRT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around HCRT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HCRT gene promoter:
-
- NRSF form 2
- NRSF form 1
- HOXA5
- ARP-1
- deltaCREB
- CREB
- ITF-2
- Tal-1beta
- STAT3
- FOXJ2
Regulatory Element Products
Genomic Locations for HCRT Gene
Genomic Locations for HCRT Gene
- chr17:42,184,060-42,185,452
- (GRCh38/hg38)
- Size:
- 1,393 bases
- Orientation:
- Minus strand
- chr17:40,336,078-40,337,470
- (GRCh37/hg19)
- Size:
- 1,393 bases
- Orientation:
- Minus strand
Genomic View for HCRT Gene
Genes around HCRT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
- 17q21.2 by Ensembl
HCRT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HCRT Gene
Proteins for HCRT Gene
-
Protein details for HCRT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43612-OREX_HUMAN
- Recommended name:
- Orexin
- Protein Accession:
- O43612
Protein attributes for HCRT Gene
- Size:
- 131 amino acids
- Molecular mass:
- 13363 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HCRT Gene
- Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Other Protein References for HCRT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HCRT (Orexin A/Hypocretin-1)
- R&D Systems Antibodies for HCRT (Orexin B/Hypocretin-2)
- Novus Biologicals Antibodies for HCRT
- Invitrogen Antibodies for HCRT (AFLGC-HCRT)
- antibodies-online: Search results for 41 available HCRT Antibodies ranked by validation data
- Compare Top HCRT Antibodies
-
Recommended
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- GeneTex HCRT Antibody for HCRT
-
Boster Bio Antibodies for HCRT
-
Santa Cruz Biotechnology (SCBT) Antibodies for HCRT
Protein Products
-
OriGene Purified Proteins for HCRT
- Search Origene for MassSpec and Protein Over-expression Lysates for HCRT
- Origene Custom Protein Services for HCRT
- Novus Biologicals lysates for HCRT
- antibodies-online: Search results for available HCRT related products ranked by validation data
- Search GeneTex for Proteins for HCRT
Assay Products
- antibodies-online: Search results for 34 available HCRT Elisa Kits ranked by validation data
- Compare Top HCRT Elisa Kits
-
Recommended
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
No data available for DME Specific Peptides for HCRT Gene
Domains & Families for HCRT Gene
Gene Families for HCRT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted secreted proteins
Protein Domains for HCRT Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HCRT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43612- Family:
-
- Belongs to the orexin family.
Function for HCRT Gene
Molecular function for HCRT Gene
- UniProtKB/Swiss-Prot Function:
- Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
- GENATLAS Biochemistry:
- hypocretin neuropeptide precursor of isoforms A and B,expressed in lateral hypothalamus and adjacent areas,potential mediator in the central feedback mechanism,that regulates feeding behavior,homolog to secretin,susceptibility gene for narcolepsy
Phenotypes From GWAS Catalog for HCRT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005184 | neuropeptide hormone activity | IEA | -- |
| GO:0031771 | type 1 hypocretin receptor binding | IEA | -- |
| GO:0031772 | type 2 hypocretin receptor binding | IEA | -- |
Phenotypes for HCRT Gene
- MGI mutant phenotypes for HCRT:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HCRT:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HCRT
-
CRISPR Products
-
OriGene CRISPR knockouts for HCRT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
- genomics-online: gRNA clones - Search results for available HCRT gene related products
- Applied Biological Materials CRISPR for HCRT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
- GenScript: Design CRISPR guide RNA sequences for HCRT
miRNA for HCRT Gene
- miRTarBase miRNAs that target HCRT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
- Browse OriGene Inhibitory RNA Products For HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
- genomics-online: shRNA clones - Search results for available HCRT gene related products
Clone Products
- Sino Biological Human cDNA Clone for HCRT
- Addgene plasmids for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
- genomics-online: cdna clones - Search results for available HCRT gene related products
- orf clones - Search results for available HCRT gene related products
- Applied Biological Materials Clones for HCRT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HCRT
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HCRT Gene
Localization for HCRT Gene
Subcellular locations from UniProtKB/Swiss-Prot for HCRT Gene
- Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005791 | rough endoplasmic reticulum | IEA | -- |
| GO:0008021 | synaptic vesicle | TAS | 9419374 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HCRT Gene
Pathways & Interactions for HCRT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Neuroscience | ||
Pathways by source for HCRT Gene
1 Cell Signaling Technology pathway for HCRT Gene
Interacting Proteins for HCRT Gene
GPS-Prot Interaction Network for HCRT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001659 | temperature homeostasis | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
| GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | -- |
Drugs & Compounds for HCRT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pidolic Acid | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for HCRT Gene
mRNA/cDNA for HCRT Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000293330 577 bps (uc002hzc.1)
Unigene Clusters for HCRT Gene
CRISPR Products
-
OriGene CRISPR knockouts for HCRT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
- genomics-online: gRNA clones - Search results for available HCRT gene related products
- Applied Biological Materials CRISPR for HCRT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
- GenScript: Design CRISPR guide RNA sequences for HCRT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
- Browse OriGene Inhibitory RNA Products For HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
- genomics-online: shRNA clones - Search results for available HCRT gene related products
Clone Products
- Sino Biological Human cDNA Clone for HCRT
- Addgene plasmids for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
- genomics-online: cdna clones - Search results for available HCRT gene related products
- orf clones - Search results for available HCRT gene related products
- Applied Biological Materials Clones for HCRT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HCRT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HCRT Gene
This gene is overexpressed in Brain - Hypothalamus (x51.1).
NURSA nuclear receptor signaling pathways regulating expression of HCRT Gene:
HCRTSOURCE GeneReport for Unigene cluster for HCRT Gene:
Hs.158348mRNA Expression by UniProt/SwissProt for HCRT Gene:
O43612-OREX_HUMAN
Tissue specificity:
Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for HCRT Gene
- Nervous system(3.6)
- Adrenal gland(2.3)
- Muscle(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HCRT Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
- mouth
- pharynx
Thorax:
- heart
General:
- blood vessel
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for HCRT
-
OriGene qPCR primer pairs and template standards for HCRT
- genomics-online: primer clones - Search results for available HCRT gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HCRT Gene
Orthologs for HCRT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HCRT 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BORX 34 |
|
OneToOne | |
| HCRT 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | HCRT 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hcrt 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hcrt 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HCRT 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HCRT 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HCRT 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hcrt 34 |
|
OneToOne |
- Species where no ortholog for HCRT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HCRT Gene
- ENSEMBL:
- Gene Tree for HCRT (if available)
- TreeFam:
- Gene Tree for HCRT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HCRT: view image
Paralogs for HCRT Gene
No data available for Paralogs for HCRT Gene
Variants for HCRT Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894574 | pathogenic, Narcolepsy 1, Narcolepsy 1 (NRCLP1) [MIM:161400] | 42,184,503(-) | A/C | coding_sequence_variant, missense_variant | |
| rs1000249432 | -- | 42,184,867(-) | A/G | intron_variant | |
| rs1000855419 | -- | 42,184,337(-) | G/C | coding_sequence_variant, synonymous_variant | |
| rs1001729743 | -- | 42,186,087(-) | C/T | upstream_transcript_variant | |
| rs1002003152 | -- | 42,186,766(-) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056904 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
Gene Damage Index Score:
0.73;
15.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HCRT Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRT Gene
Disorders for HCRT Gene
(34) MalaCards diseases for HCRT Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| narcolepsy 1 |
|
|
| narcolepsy |
|
|
| sleep disorder |
|
|
| idiopathic hypersomnia |
|
|
| recurrent hypersomnia |
|
Search HCRT in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
OREX_HUMAN- Narcolepsy 1 (NRCLP1) [MIM:161400]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:10973318}. Note=The disease is caused by mutations affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.
Additional Disease Information for HCRT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HCRT Gene
Publications for HCRT Gene
- Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. (PMID: 16429482) Takai T … Ikegami T (Journal of peptide science : an official publication of the European Peptide Society 2006) 3 4 22 58
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PMID: 9491897) Sakurai T … Yanagisawa M (Cell 1998) 2 3 4 58
- Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. (PMID: 20129934) Knudsen S … Jennum PJ (Brain : a journal of neurology 2010) 3 22 58
- Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
Products for HCRT Gene
- R&D Systems Antibodies for HCRT (Orexin A/Hypocretin-1)
- R&D Systems Antibodies for HCRT (Orexin B/Hypocretin-2)
- R&D Systems Peptides for HCRT (Orexin A/Hypocretin-1)
- R&D Systems Peptides for HCRT (Orexin B/Hypocretin-2)
- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HCRT
- Search Origene for MassSpec and Protein Over-expression Lysates for HCRT
- Origene Custom Protein Services for HCRT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HCRT
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- OriGene qPCR primer pairs for HCRT
- OriGene qPCR primer pairs and template standards for HCRT
- OriGene CRISPR knockouts for HCRT
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for HCRT
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
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- Sino Biological Human cDNA Clone for HCRT
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HCRT
- Novus Biologicals lysates for HCRT
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for HCRT (AFLGC-HCRT)
- Cyagen custom Knockout/knockin (KOKI) mouse models for HCRT
- Addgene plasmids for HCRT
- antibodies-online: Search results for 41 available HCRT Antibodies ranked by validation data
- Compare Top HCRT Antibodies
- Recommended
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 6 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 17 IHC (p) Antibodies (anti-human)
- 8 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- antibodies-online: Search results for 34 available HCRT Elisa Kits ranked by validation data
- Compare Top HCRT Elisa Kits
- Recommended
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 3 Dog (Canine) ELISA Kits
- 10 Human ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 6 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Wild boar (Sus scrofa) ELISA Kit
- antibodies-online: Search results for available HCRT related products ranked by validation data
- GeneTex HCRT Antibody for HCRT
- Search GeneTex for Proteins for HCRT
- Santa Cruz Biotechnology (SCBT) Antibodies for HCRT
- Search Santa Cruz Biotechnology (SCBT) for HCRT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HCRT
- Horizon Cell Lines for HCRT
- genomics-online: cdna clones - Search results for available HCRT gene related products
- orf clones - Search results for available HCRT gene related products
- genomics-online: gRNA clones - Search results for available HCRT gene related products
- genomics-online: primer clones - Search results for available HCRT gene related products
- genomics-online: shRNA clones - Search results for available HCRT gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HCRT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HCRT
- GeneCopoeia miRNA 3'UTR Target clone products for HCRT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT
- Boster Bio Antibodies for HCRT
- Browse Boster Bio ELISA Kits
Sources for HCRT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt