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Aliases for HCRT Gene

Aliases for HCRT Gene

  • Hypocretin Neuropeptide Precursor 2 3 5
  • Prepro-Orexin 2 3
  • Orexin 2 3
  • PPOX 3 4
  • OX 3 4
  • Hypocretin (Orexin) Neuropeptide Precursor 2
  • Hypocretin (Orexin) Neuropeptide 3
  • Hypocretin 4
  • NRCLP1 3
  • PPORX 4
  • Hcrt 4

External Ids for HCRT Gene

Previous GeneCards Identifiers for HCRT Gene

  • GC17M039901
  • GC17M042492
  • GC17M040244
  • GC17M040709
  • GC17M037589
  • GC17M040337
  • GC17M036101

Summaries for HCRT Gene

Entrez Gene Summary for HCRT Gene

  • This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

GeneCards Summary for HCRT Gene

HCRT (Hypocretin Neuropeptide Precursor) is a Protein Coding gene. Diseases associated with HCRT include Narcolepsy 1 and Narcolepsy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include type 1 hypocretin receptor binding and type 2 hypocretin receptor binding.

UniProtKB/Swiss-Prot for HCRT Gene

  • Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Additional gene information for HCRT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRT Gene

Genomics for HCRT Gene

GeneHancer (GH) Regulatory Elements for HCRT Gene

Promoters and enhancers for HCRT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042182 Enhancer 1.2 Ensembl ENCODE 650.7 +1.3 1330 2.4 HDGF FOXA2 ARNT ARID4B FEZF1 DMAP1 YBX1 SLC30A9 ZNF207 ZNF143 GC17P042182 GC17P042183 HCRT ENSG00000267340 KAT2A RETREG3 HMGN1P29 ENSG00000267002 ENSG00000267758 HSD17B1
GH17J042110 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.3 +73.1 73050 3.3 HDGF HDAC1 ARID4B IRF4 RAD21 YY1 ZNF335 ZNF207 BCLAF1 RUNX3 DHX58 GC17P042116 PIR51780 CNP KCNH4 HCRT RAB5C IFI35 AOC4P KAT2A
GH17J042245 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -65.9 -65877 11 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF213 STAT5B STAT5A HMGN1P29 ENSG00000267758 GHDC HCRT KCNH4 RPL27 NAGLU PLEKHH3
GH17J042515 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -336.4 -336441 12.2 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NBR2 MLX TUBG2 ENSG00000266962 ENSG00000267002 CAVIN1 NAGLU ENSG00000267340 RAB5C KAT2A
GH17J042128 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 +52.5 52465 8.4 HDGF FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 SP5 DHX58 CNP HSPB9 CNTD1 NBR2 RETREG3 RAB5C KCNH4 HCRT ZNF385C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HCRT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HCRT gene promoter:
  • NRSF form 2
  • NRSF form 1
  • HOXA5
  • ARP-1
  • deltaCREB
  • CREB
  • ITF-2
  • Tal-1beta
  • STAT3
  • FOXJ2

Genomic Locations for HCRT Gene

Genomic Locations for HCRT Gene
chr17:42,184,060-42,185,452
(GRCh38/hg38)
Size:
1,393 bases
Orientation:
Minus strand
chr17:40,336,078-40,337,470
(GRCh37/hg19)
Size:
1,393 bases
Orientation:
Minus strand

Genomic View for HCRT Gene

Genes around HCRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCRT Gene

Proteins for HCRT Gene

  • Protein details for HCRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43612-OREX_HUMAN
    Recommended name:
    Orexin
    Protein Accession:
    O43612

    Protein attributes for HCRT Gene

    Size:
    131 amino acids
    Molecular mass:
    13363 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HCRT Gene

neXtProt entry for HCRT Gene

Post-translational modifications for HCRT Gene

  • Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Other Protein References for HCRT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HCRT (Orexin A/Hypocretin-1)
  • R&D Systems Antibodies for HCRT (Orexin B/Hypocretin-2)
  • Boster Bio Antibodies for HCRT

No data available for DME Specific Peptides for HCRT Gene

Domains & Families for HCRT Gene

Gene Families for HCRT Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for HCRT Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HCRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43612

UniProtKB/Swiss-Prot:

OREX_HUMAN :
  • Belongs to the orexin family.
Family:
  • Belongs to the orexin family.
genes like me logo Genes that share domains with HCRT: view

Function for HCRT Gene

Molecular function for HCRT Gene

UniProtKB/Swiss-Prot Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
GENATLAS Biochemistry:
hypocretin neuropeptide precursor of isoforms A and B,expressed in lateral hypothalamus and adjacent areas,potential mediator in the central feedback mechanism,that regulates feeding behavior,homolog to secretin,susceptibility gene for narcolepsy

Phenotypes From GWAS Catalog for HCRT Gene

Gene Ontology (GO) - Molecular Function for HCRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IEA --
GO:0031771 type 1 hypocretin receptor binding IEA --
GO:0031772 type 2 hypocretin receptor binding IEA --
genes like me logo Genes that share ontologies with HCRT: view
genes like me logo Genes that share phenotypes with HCRT: view

Human Phenotype Ontology for HCRT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HCRT Gene

MGI Knock Outs for HCRT:
  • Hcrt Hcrt<tm1Ywa>
  • Hcrt Hcrt<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for HCRT Gene

miRTarBase miRNAs that target HCRT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HCRT Gene

Localization for HCRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCRT Gene

Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCRT gene
Compartment Confidence
extracellular 5
nucleus 3
endoplasmic reticulum 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HCRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0008021 synaptic vesicle TAS 9419374
genes like me logo Genes that share ontologies with HCRT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HCRT Gene

Pathways & Interactions for HCRT Gene

genes like me logo Genes that share pathways with HCRT: view

Pathways by source for HCRT Gene

SIGNOR curated interactions for HCRT Gene

Activates:

Gene Ontology (GO) - Biological Process for HCRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HCRT: view

Drugs & Compounds for HCRT Gene

(46) Drugs for HCRT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic Acid Approved, Investigational Pharma Target 0

(16) Additional Compounds for HCRT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HCRT: view

Transcripts for HCRT Gene

mRNA/cDNA for HCRT Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCRT Gene

Hypocretin (orexin) neuropeptide precursor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCRT

Alternative Splicing Database (ASD) splice patterns (SP) for HCRT Gene

No ASD Table

Relevant External Links for HCRT Gene

GeneLoc Exon Structure for
HCRT
ECgene alternative splicing isoforms for
HCRT

Expression for HCRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HCRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCRT Gene

This gene is overexpressed in Brain - Hypothalamus (x51.1).

NURSA nuclear receptor signaling pathways regulating expression of HCRT Gene:

HCRT

SOURCE GeneReport for Unigene cluster for HCRT Gene:

Hs.158348

mRNA Expression by UniProt/SwissProt for HCRT Gene:

O43612-OREX_HUMAN
Tissue specificity: Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for HCRT Gene

  • Nervous system(3.6)
  • Adrenal gland(2.3)
  • Muscle(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HCRT Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
Thorax:
  • heart
General:
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with HCRT: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HCRT Gene

Orthologs for HCRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HCRT 34 33
  • 99.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BORX 34
  • 90 (a)
OneToOne
HCRT 33
  • 88.04 (n)
dog
(Canis familiaris)
Mammalia HCRT 34 33
  • 87.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcrt 33
  • 83.92 (n)
mouse
(Mus musculus)
Mammalia Hcrt 16 34 33
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia HCRT 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCRT 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HCRT 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hcrt 34
  • 34 (a)
OneToOne
Species where no ortholog for HCRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCRT Gene

ENSEMBL:
Gene Tree for HCRT (if available)
TreeFam:
Gene Tree for HCRT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HCRT: view image

Paralogs for HCRT Gene

No data available for Paralogs for HCRT Gene

Variants for HCRT Gene

Sequence variations from dbSNP and Humsavar for HCRT Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs104894574 pathogenic, Narcolepsy 1, Narcolepsy 1 (NRCLP1) [MIM:161400] 42,184,503(-) A/C coding_sequence_variant, missense_variant
rs1000249432 -- 42,184,867(-) A/G intron_variant
rs1000855419 -- 42,184,337(-) G/C coding_sequence_variant, synonymous_variant
rs1001729743 -- 42,186,087(-) C/T upstream_transcript_variant
rs1002003152 -- 42,186,766(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HCRT Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for HCRT Gene

Gene Damage Index Score: 0.73; 15.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCRT Gene

Human Gene Mutation Database (HGMD)
HCRT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCRT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRT Gene

Disorders for HCRT Gene

MalaCards: The human disease database

(34) MalaCards diseases for HCRT Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
narcolepsy 1
  • nrclp1
narcolepsy
  • narcolepsy, without cataplexy
sleep disorder
  • non-organic sleep disorder
idiopathic hypersomnia
  • idiopathic hypersomnolence
recurrent hypersomnia
  • primary recurrent hypersomnia
- elite association - COSMIC cancer census association via MalaCards
Search HCRT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OREX_HUMAN
  • Narcolepsy 1 (NRCLP1) [MIM:161400]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:10973318}. Note=The disease is caused by mutations affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.

Additional Disease Information for HCRT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HCRT: view

No data available for Genatlas for HCRT Gene

Publications for HCRT Gene

  1. Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. (PMID: 16429482) Takai T … Ikegami T (Journal of peptide science : an official publication of the European Peptide Society 2006) 3 4 22 58
  2. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. (PMID: 9491897) Sakurai T … Yanagisawa M (Cell 1998) 2 3 4 58
  3. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. (PMID: 20129934) Knudsen S … Jennum PJ (Brain : a journal of neurology 2010) 3 22 58
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58

Products for HCRT Gene

  • Addgene plasmids for HCRT

Sources for HCRT Gene

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