Aliases for HCN2 Gene
- Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2 2 3 5
- BCNG-2 2 3 4
- Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 3 4
- Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2 2 3
- Brain Cyclic Nucleotide-Gated Channel 2 3 4
- BCNG2 3 4
- HAC-1 2 3
- Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 2
- HCN2 5
External Ids for HCN2 Gene
Previous HGNC Symbols for HCN2 Gene
Previous GeneCards Identifiers for HCN2 Gene
The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]
GeneCards Summary for HCN2 Gene
HCN2 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2) is a Protein Coding gene. Diseases associated with HCN2 include Epilepsy and Epilepsy, Idiopathic Generalized. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and TarBasePathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is HCN4.
UniProtKB/Swiss-Prot Summary for HCN2 Gene
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
HCN (hyperpolarization-activated, cyclic nucleotide-gated) channels are members of the cyclic nucleotide-regulated channel family along with cyclic nucleotide-gated (CNG) channels. They are cationic channels that open under hyperpolarization.