Aliases for HCN1 Gene
- Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1 2 3 5
- Brain Cyclic Nucleotide-Gated Channel 1 3 4
- BCNG-1 3 4
- BCNG1 3 4
- Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1 3
- Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 2
- EIEE24 3
- HAC-2 3
External Ids for HCN1 Gene
Previous HGNC Symbols for HCN1 Gene
Previous GeneCards Identifiers for HCN1 Gene
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
GeneCards Summary for HCN1 Gene
HCN1 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1) is a Protein Coding gene. Diseases associated with HCN1 include Epileptic Encephalopathy, Early Infantile, 24 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Sweet Taste Signaling and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is HCN4.
UniProtKB/Swiss-Prot for HCN1 Gene
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
HCN (hyperpolarization-activated, cyclic nucleotide-gated) channels are members of the cyclic nucleotide-regulated channel family along with cyclic nucleotide-gated (CNG) channels. They are cationic channels that open under hyperpolarization.