Aliases for HCG22 Gene

Aliases for HCG22 Gene

  • HLA Complex Group 22 (Gene/Pseudogene) 2 3 5
  • Panbronchiolitis-Related Mucin-Like Protein 2 3 4
  • HLA Complex Group 22 (Non-Protein Coding) 2 3
  • Panbronchiolitis Related Mucin-Like 2 2 3
  • HLA Complex Group 22 2 4
  • Protein PBMUCL2 3 4
  • PBMUCL2 3 4
  • G2 4

External Ids for HCG22 Gene

Previous GeneCards Identifiers for HCG22 Gene

  • GC06U900708
  • GC06P031129
  • GC06Pf31157
  • GC06P031022

Summaries for HCG22 Gene

GeneCards Summary for HCG22 Gene

HCG22 (HLA Complex Group 22 (Gene/Pseudogene)) is a Protein Coding gene.

Additional gene information for HCG22 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCG22 Gene

Genomics for HCG22 Gene

GeneHancer (GH) Regulatory Elements for HCG22 Gene

Promoters and enhancers for HCG22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031053 Enhancer 0.5 Ensembl 531.5 +0.6 551 0.8 ZIC2 MEF2B PBX2 PBX3 MAZ PKNOX1 EBF1 RELB ZFP36 HCG22 GQ472773-001 lnc-MUC22-1 PSORS1C1 HSALNG0049229
GH06J031113 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 25.7 +61.6 61559 2.3 ZNF217 CTCF JUND FOS ZIC2 REST POLR2A CLOCK TSC22D4 EP300 PSORS1C1 HCG22 POU5F1 HLA-C TRIM10 TCF19 CDSN
GH06J031094 Enhancer 1 Ensembl ENCODE 32.3 +42.0 41951 5.2 NCOR1 TSC22D4 TEAD1 MCM3 RBM25 FOXA2 NFIC FOSL1 BCOR TAL1 HCG22 NRM TCF19 LSM2 PSORS1C2 DHX16 MICA TRIM39 DDX39B ENSG00000272221
GH06J031352 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 +302.7 302742 7 ZBTB40 SP1 ZBTB10 POLR2A FOS RELA RCOR1 NFYB ZNF266 KLF9 HLA-B ENSG00000271581 MIR6891 NONHSAG043472.2 lnc-HLA-C-2 piR-47864 HLA-C DDX39B MICA LY6G5B
GH06J031056 Enhancer 1 Ensembl ENCODE 29.2 +4.4 4352 2.4 CTCF JUND FOS ZNF639 TRIM28 REST TGIF2 CTBP1 SMC3 ZNF316 HCG22 HLA-C PSORS1C1 PSORS1C3 MICB GQ472773-001 lnc-MUC22-1 HSALNG0049229
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HCG22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCG22

Top Transcription factor binding sites by QIAGEN in the HCG22 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma1
  • PPAR-gamma2
  • Zic1

Genomic Locations for HCG22 Gene

Genomic Locations for HCG22 Gene
chr6:31,053,450-31,059,890
(GRCh38/hg38)
Size:
6,441 bases
Orientation:
Plus strand
chr6:31,021,227-31,027,667
(GRCh37/hg19)
Size:
6,441 bases
Orientation:
Plus strand

Genomic View for HCG22 Gene

Genes around HCG22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCG22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCG22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HCG22 Gene

  • Protein details for HCG22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E2RYF7-PBMU2_HUMAN
    Recommended name:
    Protein PBMUCL2
    Protein Accession:
    E2RYF7

    Protein attributes for HCG22 Gene

    Size:
    251 amino acids
    Molecular mass:
    26282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HCG22 Gene

Post-translational modifications for HCG22 Gene

  • Glycosylation at Asn120

Other Protein References for HCG22 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for HCG22 Gene

Domains & Families for HCG22 Gene

Protein Domains for HCG22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HCG22 Gene

GenScript: Design optimal peptide antigens:
  • Panbronchiolitis-related mucin-like protein 2 (PBMU2_HUMAN)
genes like me logo Genes that share domains with HCG22: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HCG22 Gene

Function for HCG22 Gene

Phenotypes From GWAS Catalog for HCG22 Gene

genes like me logo Genes that share phenotypes with HCG22: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCG22 Gene

Localization for HCG22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCG22 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for HCG22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HCG22: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HCG22 Gene

Pathways & Interactions for HCG22 Gene

PathCards logo

SuperPathways for HCG22 Gene

No Data Available

Interacting Proteins for HCG22 Gene

;

Gene Ontology (GO) - Biological Process for HCG22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HCG22 Gene

Drugs & Compounds for HCG22 Gene

(1) Drugs for HCG22 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Triamcinolone Approved, Vet_approved Pharma Agonist 709
genes like me logo Genes that share compounds with HCG22: view

Transcripts for HCG22 Gene

mRNA/cDNA for HCG22 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCG22 Gene

No ASD Table

Relevant External Links for HCG22 Gene

GeneLoc Exon Structure for
HCG22

Expression for HCG22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCG22 Gene

mRNA differential expression in normal tissues according to GTEx for HCG22 Gene

This gene is overexpressed in Vagina (x20.5), Esophagus - Mucosa (x11.7), Cervix - Ectocervix (x8.2), and Minor Salivary Gland (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCG22

SOURCE GeneReport for Unigene cluster for HCG22 Gene:

Hs.207528

mRNA Expression by UniProt/SwissProt for HCG22 Gene:

E2RYF7-PBMU2_HUMAN
Tissue specificity: Detected in the brain, lung, spleen, thymus and prostate.
genes like me logo Genes that share expression patterns with HCG22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCG22 Gene

Orthologs for HCG22 Gene

Evolution for HCG22 Gene

ENSEMBL:
Gene Tree for HCG22 (if available)
TreeFam:
Gene Tree for HCG22 (if available)

No data available for Orthologs for HCG22 Gene

Paralogs for HCG22 Gene

No data available for Paralogs for HCG22 Gene

Variants for HCG22 Gene

Structural Variations from Database of Genomic Variants (DGV) for HCG22 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2731805 CNV deletion 23290073
esv2731808 CNV deletion 23290073
esv2731809 CNV deletion 23290073
esv27565 CNV loss 19812545
esv3411275 CNV duplication 20981092
esv3567519 CNV deletion 23714750
esv3608524 CNV loss 21293372
esv4161 CNV loss 18987735
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv511865 CNV loss 21212237
nsv524716 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601488 CNV loss 21841781

Additional Variant Information for HCG22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCG22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for HCG22 Gene

Disorders for HCG22 Gene

Additional Disease Information for HCG22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HCG22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCG22 Gene

Publications for HCG22 Gene

  1. Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension. (PMID: 25813999) Jeong S … Fini ME (Investigative ophthalmology & visual science 2015) 2 3 54
  2. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. (PMID: 20981447) Hijikata M … Keicho N (Human genetics 2011) 3 4 54
  3. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. (PMID: 21051598) International HIV Controllers Study … Zhao M (Science (New York, N.Y.) 2010) 3 41 54
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 54

Products for HCG22 Gene

Sources for HCG22 Gene