This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts... See more...

Aliases for HCFC2 Gene

Aliases for HCFC2 Gene

  • Host Cell Factor C2 2 3 5
  • HCF-2 2 3 4
  • Host Cell Factor 2 3 4
  • C2 Factor 3 4
  • HCFC2 5
  • HCF2 3

External Ids for HCFC2 Gene

Previous GeneCards Identifiers for HCFC2 Gene

  • GC12P102961
  • GC12P102962
  • GC12P104458
  • GC12P101517

Summaries for HCFC2 Gene

Entrez Gene Summary for HCFC2 Gene

  • This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HCFC2 Gene

HCFC2 (Host Cell Factor C2) is a Protein Coding gene. Diseases associated with HCFC2 include Herpes Simplex. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is HCFC1.

Additional gene information for HCFC2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCFC2 Gene

Genomics for HCFC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HCFC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J104063 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 177 3 ZNF629 TFE3 NFKBIZ ZNF692 POLR2A BACH1 LARP7 MTA2 ZNF143 ZIC2 HCFC2 GLT8D2 NONHSAG012135.2 NFYB C12orf73
GH12J104666 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 9.8 +606.0 605972 7.5 ARHGAP35 SP1 CREB1 CTCF PRDM10 ZNF629 LEF1 IKZF1 ZNF692 POLR2A CHST11 WASHC4 TDG RPL18AP3 EID3 HCFC2 TXNRD1 SLC41A2 LOC112268100 piR-49557
GH12J104476 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +414.7 414700 5 SP1 ZNF512 LEF1 IKZF1 BACH1 JUND LARP7 ZNF143 RELA TCF12 CHST11 EID3 HCFC2 lnc-NFYB-2 LOC107984434 SLC41A2
GH12J104135 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +72.8 72767 4.2 SP1 PRDM10 REST POLR2A BACH1 FOS JUND LARP7 RBFOX2 PATZ1 NFYB lnc-HCFC2-1 lnc-GLT8D2-1 TDG RNA5SP370 RF00001-086 MF281437-021 HCFC2
GH12J104109 Enhancer 0.9 Ensembl ENCODE 0.3 +44.2 44175 1.8 CTCF JUND ZNF143 REST RAD21 TRIM22 SOX6 GATAD2B ARID3A CBX3 EID3 MF281437-021 RNA5SP370 RF00001-086 NFYB HCFC2 RF00017-1236
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HCFC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCFC2

Top Transcription factor binding sites by QIAGEN in the HCFC2 gene promoter:
  • AP-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • Olf-1
  • Pbx1a
  • POU2F1
  • POU2F1a
  • POU3F2
  • Sp1

Genomic Locations for HCFC2 Gene

Genomic Locations for HCFC2 Gene
chr12:104,064,526-104,108,954
(GRCh38/hg38)
Size:
44,429 bases
Orientation:
Plus strand
chr12:104,458,235-104,500,302
(GRCh37/hg19)
Size:
42,068 bases
Orientation:
Plus strand

Genomic View for HCFC2 Gene

Genes around HCFC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC2 Gene

Proteins for HCFC2 Gene

  • Protein details for HCFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Z7-HCFC2_HUMAN
    Recommended name:
    Host cell factor 2
    Protein Accession:
    Q9Y5Z7
    Secondary Accessions:
    • B2R8Q5
    • C0H5X3

    Protein attributes for HCFC2 Gene

    Size:
    792 amino acids
    Molecular mass:
    86779 Da
    Quaternary structure:
    • Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.

    Alternative splice isoforms for HCFC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCFC2 Gene

Post-translational modifications for HCFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HCFC2 Gene

No data available for DME Specific Peptides for HCFC2 Gene

Domains & Families for HCFC2 Gene

Gene Families for HCFC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HCFC2 Gene

InterPro:
Blocks:
  • Binding-protein-dependent transport systems inner membrane component
ProtoNet:

Suggested Antigen Peptide Sequences for HCFC2 Gene

GenScript: Design optimal peptide antigens:
  • C2 factor (HCFC2_HUMAN)
genes like me logo Genes that share domains with HCFC2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HCFC2 Gene

Function for HCFC2 Gene

Phenotypes From GWAS Catalog for HCFC2 Gene

Gene Ontology (GO) - Molecular Function for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0003713 transcription coactivator activity TAS 10196288
GO:0004402 histone acetyltransferase activity IBA --
GO:0005515 protein binding IEA,IPI 25036637
GO:0008134 transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with HCFC2: view
genes like me logo Genes that share phenotypes with HCFC2: view

Animal Model Products

CRISPR Products

miRNA for HCFC2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCFC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HCFC2 Gene

Localization for HCFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCFC2 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 4
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10196288
GO:0005654 nucleoplasm IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IBA 21873635
GO:0005737 cytoplasm IEA,IDA 10196288
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HCFC2: view

Pathways & Interactions for HCFC2 Gene

PathCards logo

SuperPathways for HCFC2 Gene

genes like me logo Genes that share pathways with HCFC2: view

Pathways by source for HCFC2 Gene

1 KEGG pathway for HCFC2 Gene

Gene Ontology (GO) - Biological Process for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006338 chromatin remodeling IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II TAS 10196288
GO:0016032 viral process TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view

No data available for SIGNOR curated interactions for HCFC2 Gene

Drugs & Compounds for HCFC2 Gene

No Compound Related Data Available

Transcripts for HCFC2 Gene

mRNA/cDNA for HCFC2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCFC2

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for HCFC2 Gene

GeneLoc Exon Structure for
HCFC2

Expression for HCFC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCFC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for HCFC2 Gene

This gene is overexpressed in Heart (36.2) and Testis (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HCFC2 Gene



Protein tissue co-expression partners for HCFC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCFC2

SOURCE GeneReport for Unigene cluster for HCFC2 Gene:

Hs.506558

mRNA Expression by UniProt/SwissProt for HCFC2 Gene:

Q9Y5Z7-HCFC2_HUMAN
Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.

Evidence on tissue expression from TISSUES for HCFC2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with HCFC2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCFC2 Gene

Orthologs for HCFC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCFC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HCFC2 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HCFC2 30 31
  • 94.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HCFC2 30 31
  • 94.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hcfc2 30
  • 86.46 (n)
Mouse
(Mus musculus)
Mammalia Hcfc2 30 17 31
  • 86.03 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HCFC2 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HCFC2 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HCFC2 30 31
  • 74.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HCFC2 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hcfc2 30
  • 73.05 (n)
Str.17237 30
Zebrafish
(Danio rerio)
Actinopterygii hcfc2 31
  • 53 (a)
OneToOne
Dr.18404 30
Species where no ortholog for HCFC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HCFC2 Gene

ENSEMBL:
Gene Tree for HCFC2 (if available)
TreeFam:
Gene Tree for HCFC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HCFC2: view image

Paralogs for HCFC2 Gene

(1) SIMAP similar genes for HCFC2 Gene using alignment to 3 proteins:

  • HCFC2_HUMAN
  • C0H5X3_HUMAN
  • F8VU09_HUMAN

Pseudogenes.org Pseudogenes for HCFC2 Gene

genes like me logo Genes that share paralogs with HCFC2: view

Variants for HCFC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HCFC2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs17035206 - p.Gly268Ala
rs2700500 - p.Ala46Ser

Additional dbSNP identifiers (rs#s) for HCFC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HCFC2 Gene

Variant ID Type Subtype PubMed ID
esv2746313 CNV deletion 23290073
esv2746314 CNV deletion 23290073

Variation tolerance for HCFC2 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCFC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCFC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC2 Gene

Disorders for HCFC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCFC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards
Search HCFC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HCFC2

genes like me logo Genes that share disorders with HCFC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCFC2 Gene

Publications for HCFC2 Gene

  1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PMID: 10196288) Johnson KM … Wilson AC (Journal of virology 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. (PMID: 15199122) Yokoyama A … Cleary ML (Molecular and cellular biology 2004) 3 4
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3

Products for HCFC2 Gene

Sources for HCFC2 Gene