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Aliases for HCFC2 Gene

Aliases for HCFC2 Gene

  • Host Cell Factor C2 2 3 5
  • C2 Factor 3 4
  • HCF-2 3 4
  • Host Cell Factor 2 3
  • HCF2 3

External Ids for HCFC2 Gene

Previous GeneCards Identifiers for HCFC2 Gene

  • GC12P102961
  • GC12P102962
  • GC12P104458
  • GC12P101517

Summaries for HCFC2 Gene

Entrez Gene Summary for HCFC2 Gene

  • This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HCFC2 Gene

HCFC2 (Host Cell Factor C2) is a Protein Coding gene. Diseases associated with HCFC2 include Herpes Simplex. Among its related pathways are Influenza A. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is HCFC1.

Additional gene information for HCFC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC2 Gene

Genomics for HCFC2 Gene

GeneHancer (GH) Regulatory Elements for HCFC2 Gene

Promoters and enhancers for HCFC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I104063 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 151 2.8 PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 GC12M104037 GC12M104050 GLT8D2 HCFC2 NFYB C12orf73
GH12I104666 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +606.2 606222 7.8 HDGF PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 YY1 ZNF207 FOS CHST11 WASHC4 TDG RPL18AP3 EID3 HCFC2 TXNRD1 SLC41A2 PIR42556 GC12M104604
GH12I104476 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +414.8 414769 5 HDGF PKNOX1 SMAD1 IRF4 TCF12 ZNF207 ZNF143 ATF7 RUNX3 CAVIN1 CHST11 EID3 HCFC2 GC12P104468 GC12P104505
GH12I104093 Enhancer 0.2 ENCODE 0.3 +29.9 29912 1.1 NFYB GC12M104073 HCFC2 RNA5SP370
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HCFC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HCFC2 gene promoter:

Genomic Locations for HCFC2 Gene

Genomic Locations for HCFC2 Gene
42,069 bases
Plus strand

Genomic View for HCFC2 Gene

Genes around HCFC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC2 Gene

Proteins for HCFC2 Gene

  • Protein details for HCFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Host cell factor 2
    Protein Accession:
    Secondary Accessions:
    • B2R8Q5
    • C0H5X3

    Protein attributes for HCFC2 Gene

    792 amino acids
    Molecular mass:
    86779 Da
    Quaternary structure:
    • Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.

    Alternative splice isoforms for HCFC2 Gene


neXtProt entry for HCFC2 Gene

Post-translational modifications for HCFC2 Gene

No Post-translational modifications

Other Protein References for HCFC2 Gene

No data available for DME Specific Peptides for HCFC2 Gene

Domains & Families for HCFC2 Gene

Gene Families for HCFC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HCFC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCFC2: view

No data available for UniProtKB/Swiss-Prot for HCFC2 Gene

Function for HCFC2 Gene

Gene Ontology (GO) - Molecular Function for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view
genes like me logo Genes that share phenotypes with HCFC2: view

Animal Model Products

CRISPR Products

miRNA for HCFC2 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HCFC2 Gene

Localization for HCFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCFC2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10196288
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 10196288
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HCFC2: view

Pathways & Interactions for HCFC2 Gene

SuperPathways for HCFC2 Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with HCFC2: view

Pathways by source for HCFC2 Gene

1 KEGG pathway for HCFC2 Gene

Gene Ontology (GO) - Biological Process for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006357 regulation of transcription by RNA polymerase II TAS 10196288
GO:0016032 viral process TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view

No data available for SIGNOR curated interactions for HCFC2 Gene

Drugs & Compounds for HCFC2 Gene

No Compound Related Data Available

Transcripts for HCFC2 Gene

Unigene Clusters for HCFC2 Gene

Host cell factor C2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for HCFC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCFC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HCFC2 Gene

Protein differential expression in normal tissues from HIPED for HCFC2 Gene

This gene is overexpressed in Heart (36.2) and Testis (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HCFC2 Gene

Protein tissue co-expression partners for HCFC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HCFC2 Gene:


SOURCE GeneReport for Unigene cluster for HCFC2 Gene:


mRNA Expression by UniProt/SwissProt for HCFC2 Gene:

Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.

Evidence on tissue expression from TISSUES for HCFC2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with HCFC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCFC2 Gene

Orthologs for HCFC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCFC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HCFC2 33 34
  • 99.66 (n)
(Bos Taurus)
Mammalia HCFC2 33 34
  • 94.53 (n)
(Canis familiaris)
Mammalia HCFC2 33 34
  • 94.18 (n)
(Rattus norvegicus)
Mammalia Hcfc2 33
  • 86.46 (n)
(Mus musculus)
Mammalia Hcfc2 33 16 34
  • 86.03 (n)
(Monodelphis domestica)
Mammalia HCFC2 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HCFC2 34
  • 74 (a)
(Gallus gallus)
Aves HCFC2 33 34
  • 74.96 (n)
(Anolis carolinensis)
Reptilia HCFC2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hcfc2 33
  • 73.05 (n)
Str.17237 33
(Danio rerio)
Actinopterygii hcfc2 34
  • 53 (a)
Dr.18404 33
Species where no ortholog for HCFC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCFC2 Gene

Gene Tree for HCFC2 (if available)
Gene Tree for HCFC2 (if available)

Paralogs for HCFC2 Gene

Paralogs for HCFC2 Gene

(1) SIMAP similar genes for HCFC2 Gene using alignment to 3 proteins: Pseudogenes for HCFC2 Gene

genes like me logo Genes that share paralogs with HCFC2: view

Variants for HCFC2 Gene

Sequence variations from dbSNP and Humsavar for HCFC2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000125776 -- 104,082,067(+) AAA/A intron_variant
rs1000143897 -- 104,076,761(+) G/A/C intron_variant
rs1000206894 -- 104,065,731(+) G/A intron_variant
rs1000538136 -- 104,080,275(+) C/A intron_variant
rs1000575728 -- 104,066,073(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HCFC2 Gene

Variant ID Type Subtype PubMed ID
esv2746313 CNV deletion 23290073
esv2746314 CNV deletion 23290073

Variation tolerance for HCFC2 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCFC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC2 Gene

Disorders for HCFC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCFC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards
Search HCFC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HCFC2

genes like me logo Genes that share disorders with HCFC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCFC2 Gene

Publications for HCFC2 Gene

  1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PMID: 10196288) Johnson KM … Wilson AC (Journal of virology 1999) 2 3 4 58
  2. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. (PMID: 15199122) Yokoyama A … Cleary ML (Molecular and cellular biology 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for HCFC2 Gene

Sources for HCFC2 Gene

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