Aliases for HCFC1R1 Gene

Aliases for HCFC1R1 Gene

  • Host Cell Factor C1 Regulator 1 2 3 4 5
  • HPIP 2 3 4
  • Host Cell Factor C1 Regulator 1 (XPO1 Dependent) 2 3
  • HCF-1 Beta-Propeller-Interacting Protein 3 4
  • FLJ20568 2
  • HCFC1R1 5

External Ids for HCFC1R1 Gene

Previous GeneCards Identifiers for HCFC1R1 Gene

  • GC16M003072
  • GC16M003012
  • GC16M003045

Summaries for HCFC1R1 Gene

GeneCards Summary for HCFC1R1 Gene

HCFC1R1 (Host Cell Factor C1 Regulator 1) is a Protein Coding gene. Diseases associated with HCFC1R1 include Hereditary Breast Ovarian Cancer Syndrome.

UniProtKB/Swiss-Prot Summary for HCFC1R1 Gene

  • Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Additional gene information for HCFC1R1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCFC1R1 Gene

Genomics for HCFC1R1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HCFC1R1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HCFC1R1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCFC1R1

Top Transcription factor binding sites by QIAGEN in the HCFC1R1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2
  • MyoD

Genomic Locations for HCFC1R1 Gene

Genomic Locations for HCFC1R1 Gene
chr16:3,022,620-3,024,286
(GRCh38/hg38)
Size:
1,667 bases
Orientation:
Minus strand
chr16:3,072,621-3,074,287
(GRCh37/hg19)
Size:
1,667 bases
Orientation:
Minus strand

Genomic View for HCFC1R1 Gene

Genes around HCFC1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC1R1 Gene

Proteins for HCFC1R1 Gene

  • Protein details for HCFC1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW0-HPIP_HUMAN
    Recommended name:
    Host cell factor C1 regulator 1
    Protein Accession:
    Q9NWW0
    Secondary Accessions:
    • D3DUA7
    • Q68EN7

    Protein attributes for HCFC1R1 Gene

    Size:
    138 amino acids
    Molecular mass:
    15291 Da
    Quaternary structure:
    • Interacts with HCFC1.

    Alternative splice isoforms for HCFC1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCFC1R1 Gene

Post-translational modifications for HCFC1R1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HCFC1R1 Gene

Domains & Families for HCFC1R1 Gene

Gene Families for HCFC1R1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HCFC1R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HCFC1R1 Gene

GenScript: Design optimal peptide antigens:
  • HCF-1 beta-propeller-interacting protein (HPIP_HUMAN)
genes like me logo Genes that share domains with HCFC1R1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HCFC1R1 Gene

Function for HCFC1R1 Gene

Molecular function for HCFC1R1 Gene

UniProtKB/Swiss-Prot Function:
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Phenotypes From GWAS Catalog for HCFC1R1 Gene

genes like me logo Genes that share phenotypes with HCFC1R1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCFC1R1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCFC1R1 Gene

Localization for HCFC1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCFC1R1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HCFC1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HCFC1R1: view

Pathways & Interactions for HCFC1R1 Gene

PathCards logo

SuperPathways for HCFC1R1 Gene

No Data Available

Interacting Proteins for HCFC1R1 Gene

Gene Ontology (GO) - Biological Process for HCFC1R1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HCFC1R1 Gene

Drugs & Compounds for HCFC1R1 Gene

No Compound Related Data Available

Transcripts for HCFC1R1 Gene

mRNA/cDNA for HCFC1R1 Gene

8 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCFC1R1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1R1 Gene

No ASD Table

Relevant External Links for HCFC1R1 Gene

GeneLoc Exon Structure for
HCFC1R1

Expression for HCFC1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCFC1R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCFC1R1

SOURCE GeneReport for Unigene cluster for HCFC1R1 Gene:

Hs.423103

mRNA Expression by UniProt/SwissProt for HCFC1R1 Gene:

Q9NWW0-HPIP_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HCFC1R1 Gene

  • Nervous system(4.5)
  • Muscle(2.5)
  • Skin(2)
genes like me logo Genes that share expression patterns with HCFC1R1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCFC1R1 Gene

Orthologs for HCFC1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HCFC1R1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HCFC1R1 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HCFC1R1 30 31
  • 88.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HCFC1R1 30 31
  • 84.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hcfc1r1 30
  • 83.33 (n)
Mouse
(Mus musculus)
Mammalia Hcfc1r1 30 17 31
  • 83.19 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HCFC1R1 31
  • 60 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HCFC1R1 31
  • 52 (a)
OneToOne
Species where no ortholog for HCFC1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HCFC1R1 Gene

ENSEMBL:
Gene Tree for HCFC1R1 (if available)
TreeFam:
Gene Tree for HCFC1R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HCFC1R1: view image

Paralogs for HCFC1R1 Gene

No data available for Paralogs for HCFC1R1 Gene

Variants for HCFC1R1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HCFC1R1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs10508 - p.Pro92Gln

Additional dbSNP identifiers (rs#s) for HCFC1R1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HCFC1R1 Gene

Variant ID Type Subtype PubMed ID
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for HCFC1R1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCFC1R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCFC1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Disorders for HCFC1R1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCFC1R1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HCFC1R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HCFC1R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCFC1R1 Gene

Publications for HCFC1R1 Gene

  1. Interaction of HCF-1 with a cellular nuclear export factor. (PMID: 12235138) Mahajan SS … Wilson AC (The Journal of biological chemistry 2002) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. HPIP expression predicts chemoresistance and poor clinical outcomes in patients with epithelial ovarian cancer. (PMID: 27818289) Wang Y … Lou G (Human pathology 2017) 3
  5. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. (PMID: 25800793) Feng Y … Ye Q (Scientific reports 2015) 3

Products for HCFC1R1 Gene

  • Biorbyt antibodies for HCFC1R1

Sources for HCFC1R1 Gene