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Aliases for HCFC1R1 Gene

Aliases for HCFC1R1 Gene

  • Host Cell Factor C1 Regulator 1 2 3 5
  • Host Cell Factor C1 Regulator 1 (XPO1 Dependent) 2 3
  • HCF-1 Beta-Propeller-Interacting Protein 3 4
  • HPIP 3 4

External Ids for HCFC1R1 Gene

Previous GeneCards Identifiers for HCFC1R1 Gene

  • GC16M003072
  • GC16M003012
  • GC16M003045

Summaries for HCFC1R1 Gene

GeneCards Summary for HCFC1R1 Gene

HCFC1R1 (Host Cell Factor C1 Regulator 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HCFC1R1 Gene

  • Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Additional gene information for HCFC1R1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC1R1 Gene

Genomics for HCFC1R1 Gene

GeneHancer (GH) Regulatory Elements for HCFC1R1 Gene

Promoters and enhancers for HCFC1R1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.0 1993 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I003069 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -50.1 -50084 9.8 HDGF PKNOX1 YBX1 IRF4 ZNF207 ZNF143 ATF7 RUNX3 PAF1 ATF4 GC16P003518 ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 CLDN6 HCFC1R1
GH16I003128 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.5 -105.3 -105270 1.8 PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 E2F8 ARID2 ZNF143 ATF7 GC16M003129 PIR58259 ZNF213 RNU1-125P IL32 MMP25 BICDL2 LOC100128770 CLDN6 HCFC1R1
GH16I003148 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.4 -126.9 -126889 4.9 CLOCK MLX ZFP64 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC16P003506 TRP-AGG6-1 TRR-CCG1-3 TRR-CCT3-1 ZNF205 ZNF213-AS1 ZNF75A THOC6 MTCO1P28 E4F1
GH16I003095 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 -71.8 -71849 1.3 BCOR CTCF ZBTB6 ZMYM3 RAD21 RELA ZKSCAN1 POLR2A VEZF1 ZNF143 THOC6 ZNF213-AS1 SRRM2 CREBBP RNU1-125P IL32 MMP25 BICDL2 LOC100128770 HCFC1R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HCFC1R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HCFC1R1 gene promoter:

Genomic Locations for HCFC1R1 Gene

Genomic Locations for HCFC1R1 Gene
1,677 bases
Minus strand

Genomic View for HCFC1R1 Gene

Genes around HCFC1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC1R1 Gene

Proteins for HCFC1R1 Gene

  • Protein details for HCFC1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Host cell factor C1 regulator 1
    Protein Accession:
    Secondary Accessions:
    • D3DUA7
    • Q68EN7

    Protein attributes for HCFC1R1 Gene

    138 amino acids
    Molecular mass:
    15291 Da
    Quaternary structure:
    • Interacts with HCFC1.

    Alternative splice isoforms for HCFC1R1 Gene


neXtProt entry for HCFC1R1 Gene

Post-translational modifications for HCFC1R1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HCFC1R1 Gene

Domains & Families for HCFC1R1 Gene

Gene Families for HCFC1R1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HCFC1R1 Gene


Suggested Antigen Peptide Sequences for HCFC1R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCFC1R1: view

No data available for UniProtKB/Swiss-Prot for HCFC1R1 Gene

Function for HCFC1R1 Gene

Molecular function for HCFC1R1 Gene

UniProtKB/Swiss-Prot Function:
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Phenotypes From GWAS Catalog for HCFC1R1 Gene

Phenotypes for HCFC1R1 Gene

genes like me logo Genes that share phenotypes with HCFC1R1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCFC1R1 Gene

Localization for HCFC1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCFC1R1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HCFC1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HCFC1R1: view

Pathways & Interactions for HCFC1R1 Gene

SuperPathways for HCFC1R1 Gene

No Data Available

Interacting Proteins for HCFC1R1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9NWW0-HPIP_HUMAN ENSP00000248089 for HCFC1R1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for HCFC1R1 Gene


No data available for Pathways by source and SIGNOR curated interactions for HCFC1R1 Gene

Drugs & Compounds for HCFC1R1 Gene

No Compound Related Data Available

Transcripts for HCFC1R1 Gene

Unigene Clusters for HCFC1R1 Gene

Host cell factor C1 regulator 1 (XPO1 dependent):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1R1 Gene

No ASD Table

Relevant External Links for HCFC1R1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCFC1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HCFC1R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HCFC1R1 Gene:


SOURCE GeneReport for Unigene cluster for HCFC1R1 Gene:


mRNA Expression by UniProt/SwissProt for HCFC1R1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HCFC1R1 Gene

  • Nervous system(4.4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with HCFC1R1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCFC1R1 Gene

Orthologs for HCFC1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HCFC1R1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HCFC1R1 33 34
  • 100 (n)
(Bos Taurus)
Mammalia HCFC1R1 33 34
  • 88.8 (n)
(Canis familiaris)
Mammalia HCFC1R1 33 34
  • 84.03 (n)
(Rattus norvegicus)
Mammalia Hcfc1r1 33
  • 83.33 (n)
(Mus musculus)
Mammalia Hcfc1r1 33 16 34
  • 83.19 (n)
(Ornithorhynchus anatinus)
Mammalia HCFC1R1 34
  • 60 (a)
(Monodelphis domestica)
Mammalia HCFC1R1 34
  • 52 (a)
Species where no ortholog for HCFC1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HCFC1R1 Gene

Gene Tree for HCFC1R1 (if available)
Gene Tree for HCFC1R1 (if available)

Paralogs for HCFC1R1 Gene

No data available for Paralogs for HCFC1R1 Gene

Variants for HCFC1R1 Gene

Sequence variations from dbSNP and Humsavar for HCFC1R1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs587777030 pathogenic, Beaulieu-Boycott-Innes syndrome 3,025,804(-) G/A upstream_transcript_variant
rs1000616190 -- 3,023,970(-) T/C 5_prime_UTR_variant, intron_variant, splice_acceptor_variant
rs1000918889 -- 3,023,716(-) G/C intron_variant
rs1000950947 -- 3,022,677(-) C/T 3_prime_UTR_variant
rs1001001726 -- 3,023,017(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HCFC1R1 Gene

Variant ID Type Subtype PubMed ID
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for HCFC1R1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCFC1R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Disorders for HCFC1R1 Gene

Additional Disease Information for HCFC1R1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HCFC1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCFC1R1 Gene

Publications for HCFC1R1 Gene

  1. Interaction of HCF-1 with a cellular nuclear export factor. (PMID: 12235138) Mahajan SS … Wilson AC (The Journal of biological chemistry 2002) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. HPIP expression predicts chemoresistance and poor clinical outcomes in patients with epithelial ovarian cancer. (PMID: 27818289) Wang Y … Lou G (Human pathology 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. (PMID: 25800793) Feng Y … Ye Q (Scientific reports 2015) 3 58

Products for HCFC1R1 Gene

Sources for HCFC1R1 Gene

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