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HCAR3 (Hydroxycarboxylic Acid Receptor 3) is a Protein Coding gene. Diseases associated with HCAR3 include Pellagra and Distal Hereditary Motor Neuronopathy Type 2. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is HCAR2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J122716 | Promoter/Enhancer | 0.9 | Ensembl dbSUPER | 650 | -0.3 | -290 | 0.6 | CEBPA CEBPB FOXA2 SAP130 STAT3 EBF1 NFIL3 HLF POLR2A FOXA3 | HCAR3 RF00017-1323 HCAR1 | |
GH12J122714 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 650.2 | +1.5 | 1510 | 2.6 | IKZF2 CEBPB IKZF1 | HCAR3 MIR9902-2 HCAR2 ENSG00000256249 | |
GH12J122678 | Enhancer | 1.1 | Ensembl ENCODE | 54.6 | +36.6 | 36610 | 7.6 | CEBPG GATAD2A TFE3 SOX13 RCOR2 JUND PRDM1 PKNOX1 RXRB REST | RF00004-034 HCAR3 HCAR1 HCAR2 ENSG00000256044 DENR SNRNP35 piR-44050 lnc-KNTC1-3 KNTC1 | |
GH12J122733 | Enhancer | 0.6 | FANTOM5 | 67.1 | -16.9 | -16868 | 0.4 | IKZF2 SOX6 RELB NBN TBX21 ATF7 MTA2 TARDBP IKZF1 RAD51 | HCAR3 HCAR2 VPS37B CLIP1 RSRC2 C12orf65 HCAR1 RF00017-1324 DENR | |
GH12J122744 | Promoter/Enhancer | 0.7 | FANTOM5 Ensembl | 44 | -27.5 | -27490 | 0.6 | CTCF | HCAR3 HCAR2 VPS37B CLIP1 DENR ENSG00000256044 RF00017-1324 HCAR1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 7505609 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | cAMP signaling pathway | ||
4 | Hydroxycarboxylic acid-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Niacin | Approved, Investigational | Nutra | Agonist, Unknown, Full agonist, Target, agonist | 432,432 | ||
Inositol nicotinate | Approved, Withdrawn | Pharma | Target, agonist | 0 | ||
Mepenzolate | Approved | Pharma | antagonist | 0 | ||
D-Tryptophan | Experimental | Pharma | Agonist, Full agonist | 0 | ||
D-Phenylalanine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1-isopropylbenzotriazole-5-carboxylic acid |
|
Agonist, Full agonist |
|
|||
5-methyl-?àë5-(5-meth?àëylthiophe?àën-3-yl)-4?àë-oxo-4,5-?àëdihydrofu?àëran-2-car?àëboxylic a?àëcid |
|
Agonist, Full agonist |
|
|||
D-phenyalanine |
|
Agonist, Full agonist |
|
Compound | Action | Cas Number |
---|---|---|
3,5-DHBA | Selective HCA1 agonist | 99-10-5 |
Acifran | Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors | 72420-38-3 |
IBC 293 | Selective agonist for the GPR109B (HM74) receptor. Antilipolytic | 306935-41-1 |
LUF 6283 | HCA2 (GPR109A) partial agonist | 92933-48-7 |
MK 1903 | Potent and selective GPR109A (HCA2) agonist | 1268882-43-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR109B 30 |
|
||
HCAR3 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | HCAR3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | HCAR3 30 |
|
||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Niacr1 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hcar2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hcar1-3 30 |
|
||
hcar1-2 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs116821988 | - | p.Ile317Met | |||
rs118091133 | - | p.His253Arg | |||
rs1696351 | - | p.Ile346Met | |||
rs17884481 | - | p.Phe198Leu | |||
rs1798192 | - | p.Thr173Pro |
Disorder | Aliases | PubMed IDs |
---|---|---|
pellagra |
|
|
distal hereditary motor neuronopathy type 2 |
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