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HCAR2 (Hydroxycarboxylic Acid Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Hydroxycarboxylic acid-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and nicotinic acid receptor activity. An important paralog of this gene is HCAR3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0070553 | nicotinic acid receptor activity | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | cAMP signaling pathway | ||
4 | Hydroxycarboxylic acid-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001781 | neutrophil apoptotic process | IDA | 17932499 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0033031 | positive regulation of neutrophil apoptotic process | IDA | 17932499 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Niacin | Approved, Investigational | Nutra | Unknown, Agonist, Full agonist, Target, agonist | 523,523 | ||
Acipimox | Approved, Investigational | Pharma | Full agonist, Agonist | 23 | ||
Clotrimazole | Approved, Vet_approved | Pharma | Inhibition, Pore Blocker, Antagonist, Agonist, Gating inhibitor, Channel blocker, Target, partial agonist | 39 | ||
Inositol nicotinate | Approved, Withdrawn | Pharma | Target, agonist | 0 | ||
Mepenzolate | Approved | Pharma | antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
beta-D-hydroxybutyric acid |
|
Full agonist, Agonist |
|
Compound | Action | Cas Number |
---|---|---|
3,5-DHBA | Selective HCA1 agonist | 99-10-5 |
Acifran | Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors | 72420-38-3 |
IBC 293 | Selective agonist for the GPR109B (HM74) receptor. Antilipolytic | 306935-41-1 |
LUF 6283 | HCA2 (GPR109A) partial agonist | 92933-48-7 |
MK 1903 | Potent and selective GPR109A (HCA2) agonist | 1268882-43-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPR109A 32 |
|
||
cow (Bos Taurus) |
Mammalia | -- 33 |
|
OneToMany | |
rat (Rattus norvegicus) |
Mammalia | Niacr1 32 |
|
||
mouse (Mus musculus) |
Mammalia | Niacr1 33 32 |
|
OneToMany | |
Hcar2 17 |
|
||||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | hcar1-2 33 |
|
ManyToMany |
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000041315 | -- | 122,701,481(-) | A/T | 3_prime_UTR_variant | |
rs1003056847 | -- | 122,705,165(-) | A/C | upstream_transcript_variant | |
rs1003487264 | -- | 122,704,314(-) | A/G | upstream_transcript_variant | |
rs1006507857 | -- | 122,704,849(-) | C/A | upstream_transcript_variant | |
rs1007307432 | -- | 122,701,583(-) | G/T | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv308e214 | CNV | loss | 21293372 |
esv26589 | CNV | gain | 19812545 |
esv2746500 | CNV | deletion | 23290073 |
esv3630980 | CNV | gain | 21293372 |
esv8582 | CNV | loss | 19470904 |
esv8843 | CNV | loss | 19470904 |
nsv973132 | CNV | duplication | 23825009 |
No disorders were found for HCAR2 Gene.