Aliases for HCAR2 Gene
External Ids for HCAR2 Gene
Previous HGNC Symbols for HCAR2 Gene
Previous GeneCards Identifiers for HCAR2 Gene
GeneCards Summary for HCAR2 Gene
HCAR2 (Hydroxycarboxylic Acid Receptor 2) is a Protein Coding gene. Diseases associated with HCAR2 include Pellagra and Diversion Colitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and nicotinic acid receptor activity. An important paralog of this gene is HCAR3.
UniProtKB/Swiss-Prot Summary for HCAR2 Gene
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.