G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005] See more...

Aliases for HCAR1 Gene

Aliases for HCAR1 Gene

  • Hydroxycarboxylic Acid Receptor 1 2 3 4 5
  • HCA1 2 3 4
  • G Protein-Coupled Receptor 104 2 3
  • G-Protein Coupled Receptor 81 3 4
  • Lactate Receptor 1 2 3
  • TA-GPCR 2 3
  • FKSG80 2 3
  • GPR104 3 4
  • GPR81 3 4
  • LACR1 2 3
  • T-Cell Activation G Protein-Coupled Receptor 3
  • Hydroxy-Carboxylic Acid Receptor 1 3
  • G-Protein Coupled Receptor 104 4
  • G Protein-Coupled Receptor 81 2
  • TAGPCR 3
  • HCAR1 5

External Ids for HCAR1 Gene

Previous HGNC Symbols for HCAR1 Gene

  • GPR104
  • GPR81

Previous GeneCards Identifiers for HCAR1 Gene

  • GC12M123104

Summaries for HCAR1 Gene

Entrez Gene Summary for HCAR1 Gene

  • G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]

GeneCards Summary for HCAR1 Gene

HCAR1 (Hydroxycarboxylic Acid Receptor 1) is a Protein Coding gene. Diseases associated with HCAR1 include Pellagra and Diversion Colitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is HCAR2.

UniProtKB/Swiss-Prot Summary for HCAR1 Gene

  • Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.

Tocris Summary for HCAR1 Gene

  • Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is therefore akin to reverse-engineering this process.

Gene Wiki entry for HCAR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HCAR1 Gene

Genomics for HCAR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HCAR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J122729 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 535 2.2 CEBPA SAP130 BCL6 KAT7 ZBTB40 ZNF205 GATAD1 CTCF ATF2 ELF3 HCAR1 HCAR3 lnc-HCAR1-1
GH12J122732 Enhancer 0.5 FANTOM5 250.7 -1.5 -1544 0.3 KDM1A SPI1 RUNX3 HCAR1 HCAR3 HCAR2 CLIP1 VPS37B RF00017-1324 DENR
GH12J122751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 13.3 -21.8 -21778 3.8 CHD2 TBP ZBTB10 SP1 MXD4 NR2C1 MNT DEK IKZF1 BRCA1 DENR HSALNG0094677 lnc-HCAR1-2 ZCCHC8 ENSG00000272849 EIF2B1 RSRC2 DDX55 ATP6V0A2 LINC01089
GH12J122773 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 -43.8 -43838 2.2 ZBTB10 FEZF1 CEBPA ELF1 ZIC2 ZNF639 KLF7 ZNF341 SIN3A ZNF843 CCDC62 HSALNG0094681 HSALNG0094682 HCAR1 KNTC1 RSRC2 VPS37B DNAH10 HSALNG0094684 HIP1R
GH12J122678 Enhancer 1 Ensembl ENCODE 18.6 +50.6 50643 7.6 CEBPA ZNF217 CEBPB CUX1 FOXA2 SMAD4 SAP130 EP300 TAL1 PRDM1 RF00004-034 HCAR3 HCAR1 HCAR2 ENSG00000256044 DENR SNRNP35 piR-44050 ENSG00000256249 lnc-KNTC1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HCAR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HCAR1

Genomic Locations for HCAR1 Gene

Latest Assembly
chr12:122,726,076-122,730,844
(GRCh38/hg38)
Size:
4,769 bases
Orientation:
Minus strand

Previous Assembly
chr12:123,210,623-123,215,391
(GRCh37/hg19 by Entrez Gene)
Size:
4,769 bases
Orientation:
Minus strand

chr12:123,104,824-123,215,390
(GRCh37/hg19 by Ensembl)
Size:
110,567 bases
Orientation:
Minus strand

Genomic View for HCAR1 Gene

Genes around HCAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCAR1 Gene

Proteins for HCAR1 Gene

  • Protein details for HCAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXC0-HCAR1_HUMAN
    Recommended name:
    Hydroxycarboxylic acid receptor 1
    Protein Accession:
    Q9BXC0
    Secondary Accessions:
    • B2R9X4
    • Q3Y5J3
    • Q4VBN1
    • Q6NXU5

    Protein attributes for HCAR1 Gene

    Size:
    346 amino acids
    Molecular mass:
    39295 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HCAR1 Gene

Post-translational modifications for HCAR1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for HCAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HCAR1 Gene

Domains & Families for HCAR1 Gene

Gene Families for HCAR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for HCAR1 Gene

Suggested Antigen Peptide Sequences for HCAR1 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 81 (HCAR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXC0

UniProtKB/Swiss-Prot:

HCAR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCAR1: view

Function for HCAR1 Gene

Molecular function for HCAR1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.

Phenotypes From GWAS Catalog for HCAR1 Gene

Gene Ontology (GO) - Molecular Function for HCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with HCAR1: view
genes like me logo Genes that share phenotypes with HCAR1: view

Animal Models for HCAR1 Gene

MGI Knock Outs for HCAR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for HCAR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCAR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HCAR1 Gene

Localization for HCAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCAR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCAR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HCAR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HCAR1 Gene

Pathways & Interactions for HCAR1 Gene

genes like me logo Genes that share pathways with HCAR1: view

Pathways by source for HCAR1 Gene

Gene Ontology (GO) - Biological Process for HCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with HCAR1: view

No data available for SIGNOR curated interactions for HCAR1 Gene

Drugs & Compounds for HCAR1 Gene

(14) Drugs for HCAR1 Gene - From: ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Lactic acid Approved, Experimental Pharma Agonist, Full agonist 0
Niacin Approved, Investigational Nutra Agonist, Unknown 471,471
γ-hydroxybutyric acid Pharma Agonist, Full agonist 0
3,5-dihydroxybenzoic acid Pharma Agonist, Full agonist 0
3,5-DHBA Pharma Selective HCA1 agonist 0

(2) Additional Compounds for HCAR1 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-lactic ?àëacid
Agonist, Partial agonist
TC-G 1008
1621175-65-2

(5) Tocris Compounds for HCAR1 Gene

Compound Action Cas Number
Diphenyleneiodonium chloride GPR3 agonist; also inhibits NOS and NADPH oxidases 4673-26-1
PF9 tetrasodium salt Potent GPR17 agonist 851265-78-6
Prosaptide TX14(A) Potent GPR37 and GPR37L1 agonist 196391-82-9
TC-G 1008 Potent and selective GPR39 agonist 1621175-65-2
TC-O 9311 Potent and selective GPR139 agonist 444932-31-4

(5) ApexBio Compounds for HCAR1 Gene

Compound Action Cas Number
3,5-DHBA 1999-10-5
Acifran 72420-38-3
IBC 293 306935-41-1
LUF 6283 92933-48-7
MK 1903 1268882-43-4
genes like me logo Genes that share compounds with HCAR1: view

Drug products for research

Transcripts for HCAR1 Gene

mRNA/cDNA for HCAR1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HCAR1

Alternative Splicing Database (ASD) splice patterns (SP) for HCAR1 Gene

No ASD Table

Relevant External Links for HCAR1 Gene

GeneLoc Exon Structure for
HCAR1

Expression for HCAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCAR1 Gene

mRNA differential expression in normal tissues according to GTEx for HCAR1 Gene

This gene is overexpressed in Breast - Mammary Tissue (x12.0), Adipose - Visceral (Omentum) (x7.9), and Bladder (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HCAR1

SOURCE GeneReport for Unigene cluster for HCAR1 Gene:

Hs.610873

mRNA Expression by UniProt/SwissProt for HCAR1 Gene:

Q9BXC0-HCAR1_HUMAN
Tissue specificity: Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.

Evidence on tissue expression from TISSUES for HCAR1 Gene

  • Spleen(4.3)
  • Kidney(4.2)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with HCAR1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCAR1 Gene

Orthologs for HCAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCAR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HCAR1 30 31
  • 99.23 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HCAR1 30
  • 84.76 (n)
GPR81 31
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia HCAR1 30
  • 83.38 (n)
GPR81 31
  • 81 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr81 30
  • 81.85 (n)
Mouse
(Mus musculus)
Mammalia Gpr81 30 31
  • 81.48 (n)
OneToOne
Hcar1 17
Platypus
(Ornithorhynchus anatinus)
Mammalia HCAR1 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HCAR1 31
  • 74 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii hcar1-1 31
  • 39 (a)
ManyToMany
Species where no ortholog for HCAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HCAR1 Gene

ENSEMBL:
Gene Tree for HCAR1 (if available)
TreeFam:
Gene Tree for HCAR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HCAR1: view image

Paralogs for HCAR1 Gene

(9) SIMAP similar genes for HCAR1 Gene using alignment to 1 proteins:

  • HCAR1_HUMAN
genes like me logo Genes that share paralogs with HCAR1: view

Variants for HCAR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HCAR1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs35292336 - p.His43Gln
rs36124671 - p.Asp253His
VAR_025152 - p.Asp253Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HCAR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HCAR1 Gene

Variant ID Type Subtype PubMed ID
nsv913 CNV insertion 18451855

Variation tolerance for HCAR1 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HCAR1 Gene

Human Gene Mutation Database (HGMD)
HCAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCAR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCAR1 Gene

Disorders for HCAR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HCAR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pellagra
  • niacin deficiency
diversion colitis
late-onset retinal degeneration
  • lord
- elite association - COSMIC cancer census association via MalaCards
Search HCAR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HCAR1

genes like me logo Genes that share disorders with HCAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCAR1 Gene

Publications for HCAR1 Gene

  1. International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). (PMID: 21454438) Offermanns S … IJzerman AP (Pharmacological reviews 2011) 2 3 4
  2. Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. (PMID: 19047060) Liu C … Lovenberg TW (The Journal of biological chemistry 2009) 2 3 4
  3. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4
  4. Role of GPR81 in lactate-mediated reduction of adipose lipolysis. (PMID: 18952058) Cai TQ … Waters MG (Biochemical and biophysical research communications 2008) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for HCAR1 Gene

Sources for HCAR1 Gene