Aliases for HCAR1 Gene
External Ids for HCAR1 Gene
Previous HGNC Symbols for HCAR1 Gene
Previous GeneCards Identifiers for HCAR1 Gene
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
GeneCards Summary for HCAR1 Gene
HCAR1 (Hydroxycarboxylic Acid Receptor 1) is a Protein Coding gene. Diseases associated with HCAR1 include Pellagra and Diversion Colitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is HCAR2.
UniProtKB/Swiss-Prot Summary for HCAR1 Gene
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is therefore akin to reverse-engineering this process.