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G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
HCAR1 (Hydroxycarboxylic Acid Receptor 1) is a Protein Coding gene. Diseases associated with HCAR1 include Pellagra and Diversion Colitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is HCAR2.
Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is therefore akin to reverse-engineering this process.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | cAMP signaling pathway | ||
4 | Hydroxycarboxylic acid-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Niacin | Approved, Investigational | Nutra | Agonist, Unknown, Full agonist | 432,432 | ||
D-Lactic acid | Experimental | Pharma | Agonist, Full agonist | 0 | ||
γ-hydroxybutyric acid | Pharma | Agonist, Full agonist | 0 | |||
3,5-dihydroxybenzoic acid | Pharma | Agonist, Full agonist | 0 | |||
3,5-DHBA | Pharma | Selective HCA1 agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
D-lactic ?àëacid |
|
Agonist, Partial agonist |
|
|||
TC-G 1008 |
|
1621175-65-2 |
|
|
Compound | Action | Cas Number |
---|---|---|
Diphenyleneiodonium chloride | GPR3 agonist; also inhibits NOS and NADPH oxidases | 4673-26-1 |
PF9 tetrasodium salt | Potent GPR17 agonist | 851265-78-6 |
Prosaptide TX14(A) | Potent GPR37 and GPR37L1 agonist | 196391-82-9 |
TC-G 1008 | Potent and selective GPR39 agonist | 1621175-65-2 |
TC-O 9311 | Potent and selective GPR139 agonist | 444932-31-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HCAR1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HCAR1 30 |
|
||
GPR81 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | HCAR1 30 |
|
||
GPR81 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Gpr81 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gpr81 30 31 |
|
OneToOne | |
Hcar1 17 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HCAR1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HCAR1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | hcar1-1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35292336 | - | p.His43Gln | |||
rs36124671 | - | p.Asp253His | |||
VAR_025152 | - | p.Asp253Glu |
Disorder | Aliases | PubMed IDs |
---|---|---|
pellagra |
|
|
diversion colitis |
|
|
late-onset retinal degeneration |
|
|