Aliases for HBEGF Gene
External Ids for HBEGF Gene
Previous HGNC Symbols for HBEGF Gene
Previous GeneCards Identifiers for HBEGF Gene
GeneCards Summary for HBEGF Gene
HBEGF (Heparin Binding EGF Like Growth Factor) is a Protein Coding gene. Diseases associated with HBEGF include Diphtheria and Perinatal Necrotizing Enterocolitis. Among its related pathways are RET signaling and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is AREG.
UniProtKB/Swiss-Prot Summary for HBEGF Gene
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.