Aliases for HBE1 Gene
External Ids for HBE1 Gene
Previous GeneCards Identifiers for HBE1 Gene
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
GeneCards Summary for HBE1 Gene
HBE1 (Hemoglobin Subunit Epsilon 1) is a Protein Coding gene. Diseases associated with HBE1 include Hemoglobin E Disease and Hemoglobin C Disease. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is ENSG00000284931.
UniProtKB/Swiss-Prot for HBE1 Gene
The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.