Aliases for HBA2 Gene
External Ids for HBA2 Gene
Previous GeneCards Identifiers for HBA2 Gene
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for HBA2 Gene
HBA2 (Hemoglobin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with HBA2 include Hemoglobin H Disease and Alpha-Thalassemia. Among its related pathways are O2/CO2 exchange in erythrocytes and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBA1.
UniProtKB/Swiss-Prot Summary for HBA2 Gene
Involved in oxygen transport from the lung to the various peripheral tissues.