Aliases for HAVCR2 Gene
Aliases for HAVCR2 Gene
External Ids for HAVCR2 Gene
- HGNC: 18437
- Entrez Gene: 84868
- Ensembl: ENSG00000135077
- OMIM: 606652
- UniProtKB: Q8TDQ0
Previous GeneCards Identifiers for HAVCR2 Gene
- GC05M156448
- GC05M156493
- GC05M156445
- GC05M151601
- GC05M156512
Summaries for HAVCR2 Gene
-
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
GeneCards Summary for HAVCR2 Gene
HAVCR2 (Hepatitis A Virus Cellular Receptor 2) is a Protein Coding gene. Diseases associated with HAVCR2 include Hepatitis A and Hepatitis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TIMD4.
UniProtKB/Swiss-Prot for HAVCR2 Gene
-
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).
Additional gene information for HAVCR2 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAVCR2 Gene
Genomics for HAVCR2 Gene
GeneHancer (GH) Regulatory Elements for HAVCR2 Gene
Promoters and enhancers for HAVCR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HAVCR2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HAVCR2 Gene
Genomic Locations for HAVCR2 Gene
- chr5:157,085,832-157,142,869
- (GRCh38/hg38)
- Size:
- 57,038 bases
- Orientation:
- Minus strand
- chr5:156,512,843-156,569,880
- (GRCh37/hg19)
Genomic View for HAVCR2 Gene
Genes around HAVCR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.3 by Ensembl
- 5q33.3 by Entrez Gene
- 5q33.3 by HGNC
HAVCR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HAVCR2 Gene
Proteins for HAVCR2 Gene
-
Protein details for HAVCR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDQ0-HAVR2_HUMAN
- Recommended name:
- Hepatitis A virus cellular receptor 2
- Protein Accession:
- Q8TDQ0
- B2RAY2
- Q8WW60
- Q96K94
Protein attributes for HAVCR2 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 33394 Da
- Quaternary structure:
-
- Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immume response (By similarity). Interacts with BAG6 (By similarity). Interacts (phosphorylated) with PIK3R1 and PIK3R2. Interacts (not dependent on its phosphorylation status) with FYN (By similarity). Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A. Interacts (in activated T-cells) with LCK and PLCG (PubMed:26492563, PubMed:24337741).
Protein Expression for HAVCR2 Gene
Post-translational modifications for HAVCR2 Gene
- O-glycosylated with core 1 or possibly core 8 glycans.
- Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
- Glycosylation at posLast=145145 and isoforms=172
- Modification sites at PhosphoSitePlus
Other Protein References for HAVCR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HAVCR2 (TIM-3)
- Novus Biologicals Antibodies for HAVCR2
-
Abcam antibodies for HAVCR2
-
Cloud-Clone Corp. Antibodies for HAVCR2
- Invitrogen Antibodies for HAVCR2
- antibodies-online: Search results for 217 available HAVCR2 Antibodies ranked by validation data
- Compare Top HAVCR2 Antibodies
-
Recommended
- 38 WB Antibodies (anti-mouse)
- 32 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 2 WB Antibodies (anti-rat)
- 73 WB Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 73 WB Antibodies (anti-human)
- 2 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 32 FACS Antibodies (anti-mouse)
- 38 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 73 WB Antibodies (anti-human)
- 2 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 32 FACS Antibodies (anti-mouse)
- 38 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- Search GeneTex for Antibodies for HAVCR2
-
CrownBio Antibodies for HAVCR2
-
Custom Antibody ServicesProSci Antibodies for HAVCR2
- Sino Biological Antibodies for HAVCR2
Protein Products
- R&D Systems Proteins and Enzymes for HAVCR2 (TIM-3)
- Search Origene for MassSpec and Protein Over-expression Lysates for HAVCR2
- Origene Custom Protein Services for HAVCR2
- Sino Biological Recombinant Proteins for HAVCR2
- Sino Biological Cell Lysates for HAVCR2
- ProSpec Recombinant Proteins for HAVCR2
-
Cloud-Clone Corp. Proteins for HAVCR2
- Search GeneTex for Proteins for HAVCR2
-
ProSci Proteins for HAVCR2
- hepatitis A virus cellular receptor 2 [91-942]
- [92-656]
- hepatitis A virus cellular receptor 2 [91-327]
- hepatitis A virus cellular receptor 2\A0 [90-549]
- hepatitis A virus cellular receptor 2\A0 [90-548]
- hepatitis A virus cellular receptor 2 precursor [96-956]
- hepatitis A virus cellular receptor 2 [96-724]
- hepatitis A virus cellular receptor 2 [96-723]
- hepatitis A virus cellular receptor 2 [96-491]
-
Abcam proteins for HAVCR2
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for HAVCR2 (TIM-3)
-
Cloud-Clone Corp. Assay Kits for HAVCR2
- Sino Biological Assays for HAVCR2
No data available for DME Specific Peptides for HAVCR2 Gene
Domains & Families for HAVCR2 Gene
Gene Families for HAVCR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HAVCR2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HAVCR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDQ0- Family:
-
- Belongs to the immunoglobulin superfamily. TIM family.
Function for HAVCR2 Gene
Molecular function for HAVCR2 Gene
- UniProtKB/Swiss-Prot Function:
- Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).
Phenotypes From GWAS Catalog for HAVCR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25363763 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HAVCR2 Gene
- MGI mutant phenotypes for HAVCR2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for HAVCR2:
Animal Models for HAVCR2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for HAVCR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HAVCR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HAVCR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HAVCR2 gene
- Search ViGene Biosciences for HAVCR2
CRISPR Products
-
OriGene CRISPR knockouts for HAVCR2
- genomics-online: gRNA clones - Search results for available HAVCR2 gene related products
- Applied Biological Materials CRISPR for HAVCR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HAVCR2
- GenScript: Design CRISPR guide RNA sequences for HAVCR2
miRNA for HAVCR2 Gene
- miRTarBase miRNAs that target HAVCR2
-
- hsa-mir-6513-5p (MIRT459304)
- hsa-mir-887-5p (MIRT459305)
- hsa-mir-3913-5p (MIRT459306)
- hsa-mir-3122 (MIRT459307)
- hsa-mir-450a-1-3p (MIRT459308)
- hsa-mir-6780a-5p (MIRT459309)
- hsa-mir-6779-5p (MIRT459310)
- hsa-mir-3689c (MIRT459311)
- hsa-mir-3689b-3p (MIRT459312)
- hsa-mir-3689a-3p (MIRT459313)
- hsa-mir-30b-3p (MIRT459314)
- hsa-mir-1273h-5p (MIRT459315)
- hsa-mir-6788-5p (MIRT459316)
- hsa-mir-30c-2-3p (MIRT459317)
- hsa-mir-30c-1-3p (MIRT459318)
- hsa-mir-6799-5p (MIRT459319)
- hsa-mir-6883-5p (MIRT459320)
- hsa-mir-6785-5p (MIRT459321)
- hsa-mir-4728-5p (MIRT459322)
- hsa-mir-149-3p (MIRT459323)
- hsa-mir-7106-5p (MIRT459324)
- hsa-mir-1251-3p (MIRT459325)
- hsa-mir-6089 (MIRT459326)
- hsa-mir-1827 (MIRT459327)
- hsa-mir-1825 (MIRT459328)
- hsa-mir-520f-3p (MIRT459329)
- hsa-mir-302c-3p (MIRT459330)
- hsa-mir-940 (MIRT459331)
- hsa-mir-6893-5p (MIRT459332)
- hsa-mir-6808-5p (MIRT459333)
miRNA Products
- Search ViGene Biosciences for HAVCR2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HAVCR2
- Browse OriGene Inhibitory RNA Products For HAVCR2
- genomics-online: shRNA clones - Search results for available HAVCR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HAVCR2 gene
Clone Products
- Sino Biological Human cDNA Clone for HAVCR2
- VectorBuilder custom plasmid, inducible vectors for HAVCR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HAVCR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HAVCR2
- genomics-online: cdna clones - Search results for available HAVCR2 gene related products
- orf clones - Search results for available HAVCR2 gene related products
- Applied Biological Materials Clones for HAVCR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HAVCR2 (TIM-3)
Cell Line Products
-
Horizon Cell Lines for HAVCR2
-
ViGene Biosciences adenoviral particle packaged cDNA for HAVCR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HAVCR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HAVCR2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HAVCR2 Gene
Localization for HAVCR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HAVCR2 Gene
- Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. {ECO:0000269 PubMed:24337741}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0009986 | cell surface | IEA,IDA | 25363763 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HAVCR2 Gene
Pathways & Interactions for HAVCR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | NF-kappaB Signaling | ||
| 3 | T Cell Co-Signaling Pathway: Ligand-Receptor Interactions | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | RET signaling | ||
Pathways by source for HAVCR2 Gene
4 Reactome pathways for HAVCR2 Gene
1 R&D Systems pathway for HAVCR2 Gene
1 Cell Signaling Technology pathway for HAVCR2 Gene
Interacting Proteins for HAVCR2 Gene
Selected Interacting proteins:
Q8TDQ0-HAVR2_HUMAN
ENSP00000312002
for HAVCR2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001819 | positive regulation of cytokine production | IEA | -- |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002281 | macrophage activation involved in immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002519 | natural killer cell tolerance induction | IMP | 25578313 |
No data available for SIGNOR curated interactions for HAVCR2 Gene
Transcripts for HAVCR2 Gene
mRNA/cDNA for HAVCR2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HAVCR2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HAVCR2
- genomics-online: gRNA clones - Search results for available HAVCR2 gene related products
- Applied Biological Materials CRISPR for HAVCR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HAVCR2
- GenScript: Design CRISPR guide RNA sequences for HAVCR2
miRNA Products
- Search ViGene Biosciences for HAVCR2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HAVCR2
- Browse OriGene Inhibitory RNA Products For HAVCR2
- genomics-online: shRNA clones - Search results for available HAVCR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HAVCR2 gene
Clone Products
- Sino Biological Human cDNA Clone for HAVCR2
- VectorBuilder custom plasmid, inducible vectors for HAVCR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HAVCR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HAVCR2
- genomics-online: cdna clones - Search results for available HAVCR2 gene related products
- orf clones - Search results for available HAVCR2 gene related products
- Applied Biological Materials Clones for HAVCR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HAVCR2 (TIM-3)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: |
Expression for HAVCR2 Gene
mRNA differential expression in normal tissues according to GTEx for HAVCR2 Gene
This gene is overexpressed in Whole Blood (x8.4) and Kidney - Cortex (x4.0).
This gene is overexpressed in Urine (59.1) and Pancreas (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAVCR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HAVCR2 Gene:
HAVCR2SOURCE GeneReport for Unigene cluster for HAVCR2 Gene:
Hs.710500mRNA Expression by UniProt/SwissProt for HAVCR2 Gene:
Q8TDQ0-HAVR2_HUMAN
Tissue specificity:
Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
Evidence on tissue expression from TISSUES for HAVCR2 Gene
- Blood(4.7)
- Lung(4.4)
- Pancreas(4.1)
- Spleen(2.8)
- Lymph node(2.6)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for HAVCR2
-
OriGene qPCR primer pairs and template standards for HAVCR2
- genomics-online: primer clones - Search results for available HAVCR2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAVCR2 Gene
Orthologs for HAVCR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HAVCR2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HAVCR2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HAVCR2 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Havcr2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Havcr2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HAVCR2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | HAVCR1 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | timd4 34 |
|
OneToMany |
- Species where no ortholog for HAVCR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HAVCR2 Gene
(1) SIMAP similar genes for HAVCR2 Gene using alignment to 3 proteins:
Variants for HAVCR2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000140896 | -- | 157,095,754(-) | C/A | intron_variant | |
| rs1000339483 | -- | 157,107,581(-) | T/C | intron_variant | |
| rs1000375968 | -- | 157,107,863(-) | C/A/T | intron_variant | |
| rs1000499475 | -- | 157,108,566(-) | A/C | intron_variant | |
| rs1000572958 | -- | 157,108,208(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3575892 | CNV | gain | 25503493 |
| nsv1109742 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.01;
37.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HAVCR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAVCR2 Gene
Disorders for HAVCR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis a |
|
|
| hepatitis |
|
|
| far eastern spotted fever |
|
|
| histiocytic sarcoma |
|
|
| hepatitis c virus |
|
|
Search HAVCR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HAVR2_HUMAN- Note=May be involved in T-cell exhaustion associated with chronic viral infections such as with human immunodeficiency virus (HIV) and hepatitic C virus (HCV). {ECO:0000269 PubMed:19001139, ECO:0000269 PubMed:19587053}.
Additional Disease Information for HAVCR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HAVCR2 Gene
Publications for HAVCR2 Gene
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. (PMID: 11823861) Monney L … Kuchroo VK (Nature 2002) 2 3 4 22 58
- The role of T-cell immunoglobulin- and mucin-domain-containing molecule-3 polymorphisms in idiopathic thrombocytopenic purpura. (PMID: 19332093) Du WT … Yang RC (Human immunology 2009) 3 22 44 58
- Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios. (PMID: 19494522) Wu QW … Hu LH (International archives of allergy and immunology 2009) 3 22 44 58
- Lack of association of TIM3 polymorphisms and allergic phenotypes. (PMID: 19566956) Zhang J … Sandford AJ (BMC medical genetics 2009) 3 22 44 58
- Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PMID: 18294362) Nuchnoi P … Patarapotikul J (Annals of human genetics 2008) 3 22 44 58
Products for HAVCR2 Gene
- R&D Systems Antibodies for HAVCR2 (TIM-3)
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for HAVCR2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
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- VectorBuilder custom plasmid, inducible vectors for HAVCR2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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- antibodies-online: Search results for 217 available HAVCR2 Antibodies ranked by validation data
- Compare Top HAVCR2 Antibodies
- Recommended
- 73 WB Antibodies (anti-human)
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- 1 IP Antibody (anti-mouse)
- 2 WB Antibodies (anti-rat)
- 73 WB Antibodies (anti-human)
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- 2 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
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- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 2 WB Antibodies (anti-rat)
- antibodies-online: Search results for 8 available HAVCR2 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 41 available HAVCR2 Proteins ranked by validation data
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- Search GeneTex for Antibodies for HAVCR2
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- ViGene Biosciences adenoviral particle packaged cDNA for HAVCR2 gene
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- Custom Antibody ServicesProSci Antibodies for HAVCR2
- ProSci Proteins for HAVCR2
- hepatitis A virus cellular receptor 2 [96-491]
- hepatitis A virus cellular receptor 2 [96-723]
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- hepatitis A virus cellular receptor 2\A0 [90-548]
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- [92-656]
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- genomics-online: cdna clones - Search results for available HAVCR2 gene related products
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Sources for HAVCR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (21) IntAct
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- (23) PharmGKB
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- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
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- (30) GeneAnnot
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- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
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- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
