HAUS8 Gene (Protein Coding)

HAUS Augmin Like Complex Subunit 8

GC19M017049
GIFtS:
34
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al.,... See more...

Aliases for HAUS8 Gene

Aliases for HAUS8 Gene

  • HAUS Augmin Like Complex Subunit 8 2 3 5
  • HEC1/NDC80-Interacting Centrosome-Associated Protein 1 3 4
  • HEC1/NDC80 Interacting, Centrosome Associated 1 2 3
  • HAUS Augmin-Like Complex Subunit 8 3 4
  • Sarcoma Antigen NY-SAR-48 3 4
  • HICE1 3 4
  • Hec1-Interacting And Centrosome-Associated 1 3
  • NY-SAR-48 3
  • DGT4 3

External Ids for HAUS8 Gene

Previous HGNC Symbols for HAUS8 Gene

  • HICE1

Previous GeneCards Identifiers for HAUS8 Gene

  • GC19M017024
  • GC19M017025
  • GC19M017160
  • GC19M016729

Summaries for HAUS8 Gene

Entrez Gene Summary for HAUS8 Gene

  • HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS8 Gene

HAUS8 (HAUS Augmin Like Complex Subunit 8) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot Summary for HAUS8 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Additional gene information for HAUS8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAUS8 Gene

Genomics for HAUS8 Gene

GeneHancer (GH) Regulatory Elements for HAUS8 Gene

Promoters and enhancers for HAUS8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAUS8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HAUS8 gene promoter:
  • AREB6
  • Cart-1
  • Elk-1
  • GATA-1
  • GATA-3
  • GCNF
  • GCNF-1
  • GCNF-2
  • MIF-1
  • RREB-1

Genomic Locations for HAUS8 Gene

Genomic Locations for HAUS8 Gene
chr19:17,049,729-17,075,625
(GRCh38/hg38)
Size:
25,897 bases
Orientation:
Minus strand
chr19:17,160,539-17,186,435
(GRCh37/hg19)
Size:
25,897 bases
Orientation:
Minus strand

Genomic View for HAUS8 Gene

Genes around HAUS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HAUS8 Gene

Proteins for HAUS8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HAUS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT25-HAUS8_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 8
    Protein Accession:
    Q9BT25
    Secondary Accessions:
    • B4DJA7
    • C9JBZ4
    • Q49AC4
    • Q86WF0
    • Q96FX3

    Protein attributes for HAUS8 Gene

    Size:
    410 amino acids
    Molecular mass:
    44857 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.
    SequenceCaution:
    • Sequence=AAH10176.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO65172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO65172.1; Type=Frameshift; Positions=222, 241, 269, 278, 279; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS8 Gene

Protein Expression for HAUS8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HAUS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAUS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HAUS8 Gene

Domains & Families for HAUS8 Gene

Gene Families for HAUS8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HAUS8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HAUS8 Gene

GenScript: Design optimal peptide antigens:
  • Sarcoma antigen NY-SAR-48 (HAUS8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BT25

UniProtKB/Swiss-Prot:

HAUS8_HUMAN :
  • Belongs to the HAUS8 family.
Family:
  • Belongs to the HAUS8 family.
genes like me logo Genes that share domains with HAUS8: view

Function for HAUS8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for HAUS8 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes From GWAS Catalog for HAUS8 Gene

Gene Ontology (GO) - Molecular Function for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with HAUS8: view

Phenotypes for HAUS8 Gene

GenomeRNAi human phenotypes for HAUS8:
genes like me logo Genes that share phenotypes with HAUS8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS8 Gene

Localization for HAUS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS8 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IDA,IBA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with HAUS8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HAUS8 Gene

Pathways & Interactions for HAUS8 Gene

genes like me logo Genes that share pathways with HAUS8: view

Gene Ontology (GO) - Biological Process for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IMP 19427217
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051225 spindle assembly IMP 19369198
genes like me logo Genes that share ontologies with HAUS8: view

No data available for SIGNOR curated interactions for HAUS8 Gene

Drugs & Compounds for HAUS8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HAUS8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HAUS8 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: - - -
SP3: - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for HAUS8 Gene

GeneLoc Exon Structure for
HAUS8
ECgene alternative splicing isoforms for
HAUS8

Expression for HAUS8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAUS8 Gene

mRNA expression in normal human tissues for HAUS8 Gene
mRNA expression by GTEx for HAUS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HAUS8 Gene

This gene is overexpressed in Breast (18.0), Fetal ovary (12.8), Peripheral blood mononuclear cells (11.2), Testis (7.8), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HAUS8 Gene



Protein tissue co-expression partners for HAUS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAUS8 Gene:

HAUS8

SOURCE GeneReport for Unigene cluster for HAUS8 Gene:

Hs.404088

Evidence on tissue expression from TISSUES for HAUS8 Gene

  • Nervous system(5)
  • Eye(4)
genes like me logo Genes that share expression patterns with HAUS8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS8 Gene

Orthologs for HAUS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HAUS8 33 32
  • 98.37 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia HAUS8 33 32
  • 77.56 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia HAUS8 32
  • 74.27 (n)
HICE1 33
  • 68 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Haus8 32
  • 67.63 (n)
mouse
(Mus musculus)
 Mammalia Haus8 17 33 32
  • 66.28 (n)
oppossum
(Monodelphis domestica)
 Mammalia HAUS8 33
  • 52 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia HAUS8 33
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HAUS8 33 32
  • 54.3 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia haus8 32
  • 51.34 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:ch211-153a8.4 32
  • 48.17 (n)
HAUS8 33
  • 26 (a)
 OneToOne
Species where no ortholog for HAUS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS8 Gene

ENSEMBL:
Gene Tree for HAUS8 (if available)
TreeFam:
Gene Tree for HAUS8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HAUS8: view image

Paralogs for HAUS8 Gene

Pseudogenes.org Pseudogenes for HAUS8 Gene

genes like me logo Genes that share paralogs with HAUS8: view

No data available for Paralogs for HAUS8 Gene

Variants for HAUS8 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for HAUS8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000007759 -- 17,069,713(-) C/T intron_variant
rs1000015982 -- 17,070,362(-) C/T intron_variant
rs1000077348 -- 17,073,265(-) A/G intron_variant
rs1000233578 -- 17,061,991(-) A/G intron_variant
rs1000244382 -- 17,067,577(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS8 Gene

Variant ID Type Subtype PubMed ID
esv2666489 CNV deletion 23128226
esv3583266 CNV loss 25503493
esv3643810 CNV loss 21293372

Variation tolerance for HAUS8 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAUS8 Gene

Human Gene Mutation Database (HGMD)
HAUS8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS8 Gene

Disorders for HAUS8 Gene

Additional Disease Information for HAUS8

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HAUS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS8 Gene

Publications for HAUS8 Gene

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S … Pelletier L (Current biology : CB 2009) 2 3 4 56
  2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R … Goshima G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 56
  3. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. (PMID: 18362163) Wu G … Lee WH (Molecular and cellular biology 2008) 3 4 56
  4. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 56
  5. HAUS8 regulates RLR‑VISA antiviral signaling positively by targeting VISA. (PMID: 29916539) He TS … Xu LG (Molecular medicine reports 2018) 3 56

ExternalLinks

View latest publications for HAUS8 gene in Mastermind

Products for HAUS8 Gene

Sources for HAUS8 Gene