Free for academic non-profit institutions. Other users need a Commercial license
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
HAUS8 (HAUS Augmin Like Complex Subunit 8) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005515 | protein binding | IPI | 19369198 |
GO:0008017 | microtubule binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | spindle pole | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005813 | centrosome | IBA,IDA | 21399614 |
GO:0005815 | microtubule organizing center | IEA | -- |
GO:0005819 | spindle | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Cell Cycle, Mitotic |
.83
|
|
3 | Organelle biogenesis and maintenance |
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007098 | centrosome cycle | IMP | 19427217 |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | TAS | -- |
GO:0051225 | spindle assembly | IMP | 19369198 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HAUS8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HAUS8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HAUS8 30 |
|
||
HICE1 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Haus8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Haus8 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HAUS8 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HAUS8 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HAUS8 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | haus8 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-153a8.4 30 |
|
||
HAUS8 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2666489 | CNV | deletion | 23128226 |
esv3583266 | CNV | loss | 25503493 |
esv3643810 | CNV | loss | 21293372 |
No disorders were found for HAUS8 Gene.