This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by ... See more...

Aliases for HAUS4 Gene

Aliases for HAUS4 Gene

  • HAUS Augmin Like Complex Subunit 4 2 3 5
  • HAUS Augmin-Like Complex Subunit 4 3 4
  • C14orf94 3 4
  • Chromosome 14 Open Reading Frame 94 2
  • Homologous To Augmin Subunits 3
  • FLJ20424 2
  • HAUS4 5

External Ids for HAUS4 Gene

Previous HGNC Symbols for HAUS4 Gene

  • C14orf94

Previous GeneCards Identifiers for HAUS4 Gene

  • GC14M022486
  • GC14M023415
  • GC14M003533

Summaries for HAUS4 Gene

Entrez Gene Summary for HAUS4 Gene

  • This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for HAUS4 Gene

HAUS4 (HAUS Augmin Like Complex Subunit 4) is a Protein Coding gene. Diseases associated with HAUS4 include Enamel Caries. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is ENSG00000259132.

UniProtKB/Swiss-Prot Summary for HAUS4 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Additional gene information for HAUS4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAUS4 Gene

Genomics for HAUS4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HAUS4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022955 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 659.5 +0.5 510 2.7 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 NFKBIZ KDM1A ZNF692 HAUS4 MIR4707 lnc-AJUBA-2 ACIN1 RBM23 LOC102724814 NGDN PABPN1 AJUBA PSMB5
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 99.1 -22.8 -22790 7.7 RNF2 ARHGAP35 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 YBX1 PRDM10 AJUBA ACIN1 NGDN RBM23 PRMT5 C14orf93 HAUS4 LOC102724814 PABPN1 MMP14
GH14J022950 Promoter 0.3 EPDnew 600.4 +6.8 6829 0.1 HAUS4 AJUBA C14orf93 CDH24 PSMB5 PSMB11 piR-57460-165 lnc-AJUBA-2 ENSG00000257285 PRMT5
GH14J022946 Promoter 0.3 EPDnew 600.4 +10.5 10518 0.1 HAUS4 piR-57460-165 ENSG00000257285 LOC101926933 PRMT5 piR-41435-001 ENSG00000259132
GH14J022927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 72.1 +27.6 27554 3.2 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST PRMT5 ENSG00000257285 LOC101926933 TRR-ACG1-3 lnc-RBM23-2 piR-41435-001 NGDN ACIN1 HAUS4 RBM23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAUS4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HAUS4

Top Transcription factor binding sites by QIAGEN in the HAUS4 gene promoter:
  • AML1a
  • AREB6
  • E47
  • FOXL1
  • GR
  • GR-alpha
  • Pax-2
  • Pax-2b
  • POU6F1 (c2)
  • Tal-1

Genomic Locations for HAUS4 Gene

Genomic Locations for HAUS4 Gene
chr14:22,946,228-22,957,161
(GRCh38/hg38)
Size:
10,934 bases
Orientation:
Minus strand
chr14:23,415,437-23,426,370
(GRCh37/hg19)
Size:
10,934 bases
Orientation:
Minus strand

Genomic View for HAUS4 Gene

Genes around HAUS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS4 Gene

Proteins for HAUS4 Gene

  • Protein details for HAUS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D7-HAUS4_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 4
    Protein Accession:
    Q9H6D7
    Secondary Accessions:
    • B7WP17
    • D3DS34
    • Q86T15
    • Q86T16
    • Q86U43
    • Q9NX59

    Protein attributes for HAUS4 Gene

    Size:
    363 amino acids
    Molecular mass:
    42400 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=CAD62584.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS4 Gene

Post-translational modifications for HAUS4 Gene

  • Ubiquitination at Lys201 and Lys360
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HAUS4 Gene

Domains & Families for HAUS4 Gene

Gene Families for HAUS4 Gene

Protein Domains for HAUS4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS4 Gene

GenScript: Design optimal peptide antigens:
  • HAUS augmin-like complex subunit 4 (HAUS4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H6D7

UniProtKB/Swiss-Prot:

HAUS4_HUMAN :
  • Belongs to the HAUS4 family.
Family:
  • Belongs to the HAUS4 family.
genes like me logo Genes that share domains with HAUS4: view

Function for HAUS4 Gene

Molecular function for HAUS4 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes From GWAS Catalog for HAUS4 Gene

Gene Ontology (GO) - Molecular Function for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19369198
GO:0051011 microtubule minus-end binding IBA 21873635
genes like me logo Genes that share ontologies with HAUS4: view
genes like me logo Genes that share phenotypes with HAUS4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAUS4 Gene

Localization for HAUS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAUS4: view

Pathways & Interactions for HAUS4 Gene

genes like me logo Genes that share pathways with HAUS4: view

Gene Ontology (GO) - Biological Process for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IMP 19427217
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051225 spindle assembly IMP 19369198
genes like me logo Genes that share ontologies with HAUS4: view

No data available for SIGNOR curated interactions for HAUS4 Gene

Drugs & Compounds for HAUS4 Gene

No Compound Related Data Available

Transcripts for HAUS4 Gene

mRNA/cDNA for HAUS4 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS4

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - - -
SP11:
SP12: - - - - - -

Relevant External Links for HAUS4 Gene

GeneLoc Exon Structure for
HAUS4

Expression for HAUS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAUS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS4 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for HAUS4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (57.9) and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HAUS4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HAUS4

SOURCE GeneReport for Unigene cluster for HAUS4 Gene:

Hs.442782

Evidence on tissue expression from TISSUES for HAUS4 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Kidney(4.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with HAUS4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS4 Gene

Orthologs for HAUS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HAUS4 30 31
  • 99.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HAUS4 30
  • 88.61 (n)
-- 31
  • 88 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Haus4 30
  • 83.1 (n)
Mouse
(Mus musculus)
Mammalia Haus4 30 17 31
  • 81.63 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 27 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 47 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia haus4 30
  • 55.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii haus4 30 31
  • 49.14 (n)
OneToMany
Species where no ortholog for HAUS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HAUS4 Gene

ENSEMBL:
Gene Tree for HAUS4 (if available)
TreeFam:
Gene Tree for HAUS4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HAUS4: view image

Paralogs for HAUS4 Gene

Paralogs for HAUS4 Gene

Pseudogenes.org Pseudogenes for HAUS4 Gene

genes like me logo Genes that share paralogs with HAUS4: view

Variants for HAUS4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HAUS4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
719752 Benign: not provided 22,950,328(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for HAUS4 Gene

Variation tolerance for HAUS4 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAUS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HAUS4 Gene

Disorders for HAUS4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HAUS4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enamel caries
  • dental caries limited to enamel
- elite association - COSMIC cancer census association via MalaCards
Search HAUS4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with HAUS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAUS4 Gene

Publications for HAUS4 Gene

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S … Pelletier L (Current biology : CB 2009) 2 3 4
  2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R … Goshima G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. (PMID: 31594818) Yeung ATY … Dougan G (mBio 2019) 3

Products for HAUS4 Gene

  • Signalway Proteins for HAUS4

Sources for HAUS4 Gene