The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016] See more...

Aliases for HAUS2 Gene

Aliases for HAUS2 Gene

  • HAUS Augmin Like Complex Subunit 2 2 3 5
  • HAUS Augmin-Like Complex Subunit 2 3 4
  • Centrosomal Protein Of 27 KDa 3 4
  • Centrosomal Protein 27kDa 2 3
  • C15orf25 3 4
  • HsT17025 2 3
  • CEP27 3 4
  • Chromosome 15 Open Reading Frame 25 2
  • FLJ10460 2
  • HAUS2 5
  • Cep27 4

External Ids for HAUS2 Gene

Previous HGNC Symbols for HAUS2 Gene

  • C15orf25
  • CEP27

Previous GeneCards Identifiers for HAUS2 Gene

  • GC15P040630
  • GC15P042841
  • GC15P019688

Summaries for HAUS2 Gene

Entrez Gene Summary for HAUS2 Gene

  • The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]

GeneCards Summary for HAUS2 Gene

HAUS2 (HAUS Augmin Like Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot Summary for HAUS2 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Additional gene information for HAUS2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAUS2 Gene

Genomics for HAUS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HAUS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAUS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HAUS2

Top Transcription factor binding sites by QIAGEN in the HAUS2 gene promoter:
  • AP-1
  • Bach2
  • c-Fos
  • c-Jun
  • CUTL1
  • FosB
  • Fra-1
  • HNF-4alpha1
  • JunB
  • JunD

Genomic Locations for HAUS2 Gene

Genomic Locations for HAUS2 Gene
chr15:42,548,813-42,569,994
(GRCh38/hg38)
Size:
21,182 bases
Orientation:
Plus strand
chr15:42,841,008-42,862,192
(GRCh37/hg19)
Size:
21,185 bases
Orientation:
Plus strand

Genomic View for HAUS2 Gene

Genes around HAUS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS2 Gene

Proteins for HAUS2 Gene

  • Protein details for HAUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVX0-HAUS2_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 2
    Protein Accession:
    Q9NVX0
    Secondary Accessions:
    • C9JH36
    • Q9H9B3

    Protein attributes for HAUS2 Gene

    Size:
    235 amino acids
    Molecular mass:
    26933 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.

    Alternative splice isoforms for HAUS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS2 Gene

Post-translational modifications for HAUS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HAUS2 Gene

Domains & Families for HAUS2 Gene

Gene Families for HAUS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HAUS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS2 Gene

GenScript: Design optimal peptide antigens:
  • Centrosomal protein of 27 kDa (HAUS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVX0

UniProtKB/Swiss-Prot:

HAUS2_HUMAN :
  • Belongs to the HAUS2 family.
Family:
  • Belongs to the HAUS2 family.
genes like me logo Genes that share domains with HAUS2: view

Function for HAUS2 Gene

Molecular function for HAUS2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes From GWAS Catalog for HAUS2 Gene

Gene Ontology (GO) - Molecular Function for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with HAUS2: view
genes like me logo Genes that share phenotypes with HAUS2: view

Animal Model Products

CRISPR Products

miRNA for HAUS2 Gene

miRTarBase miRNAs that target HAUS2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS2 Gene

Localization for HAUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
golgi apparatus 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 14654843
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAUS2: view

Pathways & Interactions for HAUS2 Gene

genes like me logo Genes that share pathways with HAUS2: view

Gene Ontology (GO) - Biological Process for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IEA,IMP 19427217
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0031023 microtubule organizing center organization IEA --
genes like me logo Genes that share ontologies with HAUS2: view

No data available for SIGNOR curated interactions for HAUS2 Gene

Drugs & Compounds for HAUS2 Gene

No Compound Related Data Available

Transcripts for HAUS2 Gene

mRNA/cDNA for HAUS2 Gene

6 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAUS2

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for HAUS2 Gene

GeneLoc Exon Structure for
HAUS2

Expression for HAUS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAUS2 Gene

Protein differential expression in normal tissues from HIPED for HAUS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.0), Fetal ovary (6.6), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HAUS2 Gene



Protein tissue co-expression partners for HAUS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HAUS2

SOURCE GeneReport for Unigene cluster for HAUS2 Gene:

Hs.14347

Evidence on tissue expression from TISSUES for HAUS2 Gene

  • Nervous system(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with HAUS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS2 Gene

Orthologs for HAUS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HAUS2 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HAUS2 30
  • 89.65 (n)
CEP27 31
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia HAUS2 30 31
  • 88.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Haus2 30
  • 81.62 (n)
Mouse
(Mus musculus)
Mammalia Haus2 30 17 31
  • 81.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HAUS2 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HAUS2 31
  • 48 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HAUS2 30 31
  • 61.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HAUS2 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia haus2 30
  • 57.07 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-170l10.1 30
  • 49.21 (n)
HAUS2 31
  • 30 (a)
OneToOne
Species where no ortholog for HAUS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HAUS2 Gene

ENSEMBL:
Gene Tree for HAUS2 (if available)
TreeFam:
Gene Tree for HAUS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HAUS2: view image

Paralogs for HAUS2 Gene

No data available for Paralogs for HAUS2 Gene

Variants for HAUS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HAUS2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs34678957 - p.Thr76Pro

Additional dbSNP identifiers (rs#s) for HAUS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HAUS2 Gene

Variant ID Type Subtype PubMed ID
esv1090131 CNV insertion 17803354
esv2677430 CNV deletion 23128226
esv2749624 CNV deletion 23290073
esv3636275 CNV loss 21293372
esv3892679 CNV loss 25118596
nsv513429 CNV insertion 21212237
nsv528725 CNV gain 19592680
nsv958012 CNV insertion 24416366

Variation tolerance for HAUS2 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAUS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS2 Gene

Disorders for HAUS2 Gene

No disorders were found for HAUS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS2 Gene

Publications for HAUS2 Gene

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S … Pelletier L (Current biology : CB 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  3. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen JS … Mann M (Nature 2003) 2 3 4
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R … Goshima G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for HAUS2 Gene

Sources for HAUS2 Gene