The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specific... See more...

Aliases for HAT1 Gene

Aliases for HAT1 Gene

  • Histone Acetyltransferase 1 2 3 4 5
  • Histone Acetyltransferase Type B Catalytic Subunit 3 4
  • KAT1 3 4
  • EC 2.3.1.48 4

External Ids for HAT1 Gene

Previous GeneCards Identifiers for HAT1 Gene

  • GC02P170830
  • GC02P171320
  • GC02P172742
  • GC02P172981
  • GC02P172604
  • GC02P172487
  • GC02P164663
  • GC02P172779

Summaries for HAT1 Gene

Entrez Gene Summary for HAT1 Gene

  • The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for HAT1 Gene

HAT1 (Histone Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and H4 histone acetyltransferase activity.

UniProtKB/Swiss-Prot Summary for HAT1 Gene

  • Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Gene Wiki entry for HAT1 Gene

Additional gene information for HAT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAT1 Gene

Genomics for HAT1 Gene

GeneHancer (GH) Regulatory Elements for HAT1 Gene

Promoters and enhancers for HAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HAT1

Top Transcription factor binding sites by QIAGEN in the HAT1 gene promoter:
  • C/EBPalpha
  • CUTL1
  • HNF-1
  • HOXA3
  • LCR-F1
  • Pax-5
  • POU2F1
  • POU2F1a
  • Sox5
  • STAT1

Genomic Locations for HAT1 Gene

Genomic Locations for HAT1 Gene
chr2:171,922,425-171,983,686
(GRCh38/hg38)
Size:
61,262 bases
Orientation:
Plus strand
chr2:172,778,935-172,848,600
(GRCh37/hg19)
Size:
69,666 bases
Orientation:
Plus strand

Genomic View for HAT1 Gene

Genes around HAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAT1 Gene

Proteins for HAT1 Gene

  • Protein details for HAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14929-HAT1_HUMAN
    Recommended name:
    Histone acetyltransferase type B catalytic subunit
    Protein Accession:
    O14929
    Secondary Accessions:
    • Q49A44
    • Q53QF0
    • Q53SU4
    • Q6P594
    • Q8WWB9

    Protein attributes for HAT1 Gene

    Size:
    419 amino acids
    Molecular mass:
    49513 Da
    Quaternary structure:
    • Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.
    SequenceCaution:
    • Sequence=AAH18682.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HAT1 Gene

    Alternative splice isoforms for HAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAT1 Gene

Post-translational modifications for HAT1 Gene

  • Ubiquitination at Lys9, Lys15, Lys26, and Lys70
  • Modification sites at PhosphoSitePlus

Other Protein References for HAT1 Gene

Antibody Products

  • Boster Bio Antibodies for HAT1

No data available for DME Specific Peptides for HAT1 Gene

Domains & Families for HAT1 Gene

Gene Families for HAT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HAT1 Gene

GenScript: Design optimal peptide antigens:
  • Histone acetyltransferase 1 (HAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14929

UniProtKB/Swiss-Prot:

HAT1_HUMAN :
  • Belongs to the HAT1 family.
Family:
  • Belongs to the HAT1 family.
genes like me logo Genes that share domains with HAT1: view

Function for HAT1 Gene

Molecular function for HAT1 Gene

UniProtKB/Swiss-Prot Function:
Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269 PubMed:11585814, ECO:0000269 PubMed:22615379, ECO:0000269 PubMed:9427644};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.68 uM for acetyl-CoA {ECO:0000269 PubMed:22615379}; Note=kcat is 4.14 (sec-1) for acetyl-CoA. {ECO:0000269 PubMed:22615379};
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen.
GENATLAS Biochemistry:
histone actyltransferase 1,catalytic subunit,acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5 and Lys12,and H2A at Lys5,expressed in the nucleus of S-phase cells,likely involved in generating modified H4 required for replication-dependent chromatin remodeling

Enzyme Numbers (IUBMB) for HAT1 Gene

Phenotypes From GWAS Catalog for HAT1 Gene

Gene Ontology (GO) - Molecular Function for HAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity TAS 9427644
GO:0005515 protein binding IPI 19862764
GO:0010485 H4 histone acetyltransferase activity IDA 22615379
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with HAT1: view
genes like me logo Genes that share phenotypes with HAT1: view

Animal Models for HAT1 Gene

MGI Knock Outs for HAT1:
  • Hat1 Hat1<tm1.1Mrpa>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAT1

Clone Products

  • Addgene plasmids for HAT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HAT1 Gene

Localization for HAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAT1 Gene

[Isoform A]: Nucleus matrix.
[Isoform B]: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAT1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000790 nuclear chromatin IDA,IBA 14718166
GO:0005634 nucleus TAS 9427644
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HAT1: view

Pathways & Interactions for HAT1 Gene

PathCards logo

SuperPathways for HAT1 Gene

SuperPathway Contained pathways
1 Chromatin organization
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
.51
.39
3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
4 IL-2 Pathway
.36
5 ERK Signaling
.51
genes like me logo Genes that share pathways with HAT1: view

Pathways by source for HAT1 Gene

1 KEGG pathway for HAT1 Gene
6 Qiagen pathways for HAT1 Gene
  • Crosstalk Between CARM1 and ESRs
  • HMGB1 Pathway
  • Molecular Mechanisms of Cancer
  • Notch Signaling
  • Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for HAT1 Gene

Gene Ontology (GO) - Biological Process for HAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 9427644
GO:0006325 chromatin organization IEA --
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0006348 chromatin silencing at telomere IEA --
genes like me logo Genes that share ontologies with HAT1: view

No data available for SIGNOR curated interactions for HAT1 Gene

Drugs & Compounds for HAT1 Gene

(6) Drugs for HAT1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0
Anacardic acid Pharma HAT inhibitor 0
C646 Pharma HAT p300-CBP inhibitor,cell-permeable 0
MG 149 Pharma HAT inhibitor 0

(2) Additional Compounds for HAT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9

(3) ApexBio Compounds for HAT1 Gene

Compound Action Cas Number
Anacardic acid HAT inhibitor 16611-84-0
C646 HAT p300-CBP inhibitor,cell-permeable 328968-36-1
MG 149 HAT inhibitor 1243583-85-8
genes like me logo Genes that share compounds with HAT1: view

Transcripts for HAT1 Gene

mRNA/cDNA for HAT1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAT1

Clone Products

  • Addgene plasmids for HAT1

Alternative Splicing Database (ASD) splice patterns (SP) for HAT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2:
SP3: - - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for HAT1 Gene

GeneLoc Exon Structure for
HAT1

Expression for HAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HAT1 Gene

This gene is overexpressed in Testis (7.0), Bone (6.9), and Fetal ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HAT1 Gene



Protein tissue co-expression partners for HAT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HAT1

SOURCE GeneReport for Unigene cluster for HAT1 Gene:

Hs.632532

Evidence on tissue expression from TISSUES for HAT1 Gene

  • Lung(4.3)
  • Nervous system(4.3)
  • Bone marrow(2.1)
  • Intestine(2.1)
  • Lymph node(2.1)
  • Skin(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with HAT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAT1 Gene

Orthologs for HAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAT1 31 30
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HAT1 31 30
  • 95.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HAT1 31 30
  • 95.31 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hat1 30
  • 92.28 (n)
mouse
(Mus musculus)
Mammalia Hat1 17 31 30
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia HAT1 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAT1 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAT1 31 30
  • 81.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAT1 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hat1 30
  • 74.11 (n)
Str.4861 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.10191 30
zebrafish
(Danio rerio)
Actinopterygii hat1 31 30
  • 68.25 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2051 31 32 30
  • 48.9 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003264 30
  • 45.29 (n)
worm
(Caenorhabditis elegans)
Secernentea hat-1 31 30
  • 46.52 (n)
OneToOne
M03C11.4 32
  • 34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14301g 30
  • 48.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL001W 30
  • 48.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAT1 33 31 30
  • 44.1 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HAG2 30
  • 42.59 (n)
rice
(Oryza sativa)
Liliopsida Os09g0347800 30
  • 43.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hat1 30
  • 44.66 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06472 30
  • 42.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4751 31
  • 41 (a)
OneToOne
Species where no ortholog for HAT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAT1 Gene

ENSEMBL:
Gene Tree for HAT1 (if available)
TreeFam:
Gene Tree for HAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HAT1: view image

Paralogs for HAT1 Gene

Pseudogenes.org Pseudogenes for HAT1 Gene

genes like me logo Genes that share paralogs with HAT1: view

No data available for Paralogs for HAT1 Gene

Variants for HAT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HAT1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_035997 A colorectal cancer sample p.Ala317Pro

Additional dbSNP identifiers (rs#s) for HAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HAT1 Gene

Variant ID Type Subtype PubMed ID
esv2666693 CNV deletion 23128226
esv3593352 CNV loss 21293372
esv3593353 CNV loss 21293372
nsv821789 CNV loss 20364138
nsv821790 CNV loss 20364138

Variation tolerance for HAT1 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAT1 Gene

Disorders for HAT1 Gene

Additional Disease Information for HAT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAT1 Gene

Publications for HAT1 Gene

  1. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. (PMID: 9427644) Verreault A … Stillman B (Current biology : CB 1998) 2 3 4 54
  2. Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1. (PMID: 22615379) Wu H … Plotnikov AN (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 54
  3. The program for processing newly synthesized histones H3.1 and H4. (PMID: 20953179) Campos EI … Reinberg D (Nature structural & molecular biology 2010) 3 4 54
  4. Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. (PMID: 18458078) Miyamoto N … Kohno K (The Journal of biological chemistry 2008) 3 23 54
  5. Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. (PMID: 17052979) Benson LJ … Annunziato AT (The Journal of biological chemistry 2007) 3 23 54

Products for HAT1 Gene