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Aliases for HASPIN Gene

Aliases for HASPIN Gene

  • Histone H3 Associated Protein Kinase 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein Kinase 3 4
  • Germ Cell-Specific Gene 2 Protein 3 4
  • H-Haspin 3 4
  • GSG2 3 4
  • Serine/Threonine-Protein Kinase Haspin 3
  • Germ Cell Associated 2 (Haspin) 2
  • Germ Cell Associated 2, Haspin 3
  • EC 2.7.11.1 4

External Ids for HASPIN Gene

Previous HGNC Symbols for HASPIN Gene

  • GSG2

Previous GeneCards Identifiers for HASPIN Gene

  • GC17P003726
  • GC17P003727

Summaries for HASPIN Gene

GeneCards Summary for HASPIN Gene

HASPIN (Histone H3 Associated Protein Kinase) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HASPIN Gene

  • Serine/threonine-protein kinase that phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Gene Wiki entry for HASPIN Gene

Additional gene information for HASPIN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HASPIN Gene

Genomics for HASPIN Gene

GeneHancer (GH) Regulatory Elements for HASPIN Gene

Promoters and enhancers for HASPIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I003722 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.3 -0.1 -64 2.7 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 HASPIN PIR47216 PIR39862 ZZEF1 P2RX5 ENSG00000262692 ITGAE
GH17I003798 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +78.1 78133 8.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 IRF4 ZNF48 ETS1 YY1 SLC30A9 ITGAE HASPIN P2RX5 NCBP3 ZZEF1 CTNS P2RX1 GC17M003807
GH17I003690 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 -29.8 -29754 8.1 HDGF PKNOX1 SIN3A FEZF1 IRF4 ZNF121 ZNF207 ZNF143 ATF7 RUNX3 P2RX5 HASPIN P2RX5-TAX1BP3 EMC6
GH17I003665 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.6 -56.0 -55976 4.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B TAX1BP3 EMC6 CTNS P2RX5 HASPIN RPL21P125 P2RX5-TAX1BP3
GH17I003710 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.8 -11.9 -11911 3.1 HDGF HDAC1 SMAD1 BMI1 IRF4 TCF12 ZNF121 EGR1 ATF7 ETV6 HASPIN ENSG00000262692 P2RX5 P2RX5-TAX1BP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HASPIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for HASPIN Gene

Genomic Locations for HASPIN Gene
chr17:3,723,903-3,726,699
(GRCh38/hg38)
Size:
2,797 bases
Orientation:
Plus strand
chr17:3,627,197-3,630,067
(GRCh37/hg19)

Genomic View for HASPIN Gene

Genes around HASPIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HASPIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HASPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HASPIN Gene

Proteins for HASPIN Gene

  • Protein details for HASPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF76-HASP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase haspin
    Protein Accession:
    Q8TF76
    Secondary Accessions:
    • Q5U5K3
    • Q96MN1
    • Q9BXS7

    Protein attributes for HASPIN Gene

    Size:
    798 amino acids
    Molecular mass:
    88495 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HASPIN Gene

    Alternative splice isoforms for HASPIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HASPIN Gene

Post-translational modifications for HASPIN Gene

  • Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at Ser-3 in mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HASPIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HASPIN Gene

Domains & Families for HASPIN Gene

Gene Families for HASPIN Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HASPIN Gene

Suggested Antigen Peptide Sequences for HASPIN Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF76

UniProtKB/Swiss-Prot:

HASP_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
genes like me logo Genes that share domains with HASPIN: view

Function for HASPIN Gene

Molecular function for HASPIN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Enzyme Numbers (IUBMB) for HASPIN Gene

Phenotypes From GWAS Catalog for HASPIN Gene

Gene Ontology (GO) - Molecular Function for HASPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11228240
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IDA 11228240
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with HASPIN: view
genes like me logo Genes that share phenotypes with HASPIN: view

Animal Model Products

CRISPR Products

miRNA for HASPIN Gene

miRTarBase miRNAs that target HASPIN

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HASPIN Gene

Localization for HASPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HASPIN Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HASPIN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HASPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11228240
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IDA 11228240
GO:0005819 spindle IEA,IDA 15681610
genes like me logo Genes that share ontologies with HASPIN: view

Pathways & Interactions for HASPIN Gene

SuperPathways for HASPIN Gene

No Data Available

Pathways by source for HASPIN Gene

1 GeneTex pathway for HASPIN Gene

Gene Ontology (GO) - Biological Process for HASPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11228240
GO:0007049 cell cycle IEA --
GO:0007064 mitotic sister chromatid cohesion IMP 20705812
GO:0016310 phosphorylation IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with HASPIN: view

No data available for SIGNOR curated interactions for HASPIN Gene

Drugs & Compounds for HASPIN Gene

(7) Drugs for HASPIN Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
(2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol Experimental Pharma Target 0
3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine Experimental Pharma Target 0
5-iodotubercidin Experimental Pharma Target Adenosine kinase inhibitor,potent, Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE Experimental Pharma Target 0

(1) Additional Compounds for HASPIN Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for HASPIN Gene

Compound Action Cas Number
CHR-6494 Haspin inhibitor,potent ands selective 1333377-65-3
LDN 209929 dihydrochloride Haspin kinase inhibitor,potent and selective
genes like me logo Genes that share compounds with HASPIN: view

Drug Products

Transcripts for HASPIN Gene

mRNA/cDNA for HASPIN Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HASPIN Gene

No ASD Table

Relevant External Links for HASPIN Gene

GeneLoc Exon Structure for
HASPIN
ECgene alternative splicing isoforms for
HASPIN

Expression for HASPIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of HASPIN Gene:

HASPIN

mRNA Expression by UniProt/SwissProt for HASPIN Gene:

Q8TF76-HASP_HUMAN
Tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
genes like me logo Genes that share expression patterns with HASPIN: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HASPIN Gene

Orthologs for HASPIN Gene

This gene was present in the common ancestor of animals.

Orthologs for HASPIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSG2 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia GSG2 33 34
  • 82.05 (n)
cow
(Bos Taurus)
Mammalia GSG2 34 33
  • 80.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gsg2 33 34
  • 74.64 (n)
Haspin 16
rat
(Rattus norvegicus)
Mammalia Gsg2 33
  • 74.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GSG2 34
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GSG2 34
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Haspin 34
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F22H10.5 34
  • 33 (a)
OneToMany
Y40A1A.1 34
  • 33 (a)
OneToMany
Y18H1A.10 34
  • 28 (a)
OneToMany
C01H6.9 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8655 34
  • 39 (a)
OneToOne
Species where no ortholog for HASPIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HASPIN Gene

ENSEMBL:
Gene Tree for HASPIN (if available)
TreeFam:
Gene Tree for HASPIN (if available)

Paralogs for HASPIN Gene

No data available for Paralogs for HASPIN Gene

Variants for HASPIN Gene

Sequence variations from dbSNP and Humsavar for HASPIN Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000062386 -- 3,723,509(+) C/T upstream_transcript_variant
rs1000427717 -- 3,724,280(+) C/A/G coding_sequence_variant, synonymous_variant
rs1001267272 -- 3,722,650(+) G/A upstream_transcript_variant
rs1001468124 -- 3,722,493(+) A/G upstream_transcript_variant
rs1001898592 -- 3,726,398(+) A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HASPIN Gene

Variant ID Type Subtype PubMed ID
nsv1055740 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv469791 CNV loss 16826518
nsv574237 CNV loss 21841781
nsv833342 CNV loss 17160897

Variation tolerance for HASPIN Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HASPIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HASPIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HASPIN Gene

Disorders for HASPIN Gene

No disorders were found for HASPIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HASPIN Gene

Publications for HASPIN Gene

  1. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. (PMID: 17084365) Dai J … Higgins JM (Developmental cell 2006) 3 4 22 58
  2. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PMID: 15681610) Dai J … Higgins JM (Genes & development 2005) 3 4 22 58
  3. Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. (PMID: 11228240) Tanaka H … Nishimune Y (Molecular human reproduction 2001) 3 4 22 58
  4. The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells. (PMID: 11311556) Higgins JM (Gene 2001) 3 4 22 58
  5. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. (PMID: 28413956) Kestav K … Lavogina D (Current medicinal chemistry 2017) 2 3 58

Products for HASPIN Gene

Sources for HASPIN Gene

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