Aliases for HAS3 Gene
External Ids for HAS3 Gene
Previous GeneCards Identifiers for HAS3 Gene
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for HAS3 Gene
HAS3 (Hyaluronan Synthase 3) is a Protein Coding gene. Diseases associated with HAS3 include Nodular Basal Cell Carcinoma and Deafness, Autosomal Dominant 40. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS2.
UniProtKB/Swiss-Prot Summary for HAS3 Gene
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).