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Aliases for HAS1 Gene

Aliases for HAS1 Gene

  • Hyaluronan Synthase 1 2 3 3 5
  • Hyaluronic Acid Synthase 1 3 4
  • Hyaluronate Synthase 1 3 4
  • HA Synthase 1 3 4
  • HAS 3 4
  • EC 2.4.1.212 4
  • HuHAS1 4

External Ids for HAS1 Gene

Previous HGNC Symbols for HAS1 Gene

  • HAS

Previous GeneCards Identifiers for HAS1 Gene

  • GC19M052846
  • GC19M052577
  • GC19M056892
  • GC19M056908
  • GC19M052216
  • GC19M048547

Summaries for HAS1 Gene

Entrez Gene Summary for HAS1 Gene

  • Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HAS1 Gene

HAS1 (Hyaluronan Synthase 1) is a Protein Coding gene. Diseases associated with HAS1 include Waldenstrom Macroglobulinemia and Foodborne Botulism. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS3.

UniProtKB/Swiss-Prot for HAS1 Gene

  • Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).

Gene Wiki entry for HAS1 Gene

Additional gene information for HAS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAS1 Gene

Genomics for HAS1 Gene

GeneHancer (GH) Regulatory Elements for HAS1 Gene

Promoters and enhancers for HAS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051724 Promoter/Enhancer 1.1 EPDnew FANTOM5 Ensembl 653.6 -0.8 -816 0.6 POLR2A HAS1 FPR2
GH19J051723 Promoter 0.7 EPDnew 650.7 0.0 -17 0.1 EGR1 MNT HAS1 FPR2
GH19J051725 Enhancer 0.2 ENCODE 650.7 -1.4 -1384 0 HAS1 FPR2
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.1 +33.5 33503 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
GH19J051701 Promoter/Enhancer 1.5 Ensembl ENCODE 15.1 +20.5 20489 4 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZBTB7B POLR2B ZNF766 E2F8 ZNF143 SIGLEC14 HAS1 FPR1 FPR3 CEACAM18 RPL7P51 SIGLEC5 SPACA6 SPACA6P-AS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HAS1 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • p53
  • Olf-1

Genomic Locations for HAS1 Gene

Genomic Locations for HAS1 Gene
chr19:51,713,112-51,723,994
(GRCh38/hg38)
Size:
10,883 bases
Orientation:
Minus strand
chr19:52,216,365-52,227,247
(GRCh37/hg19)
Size:
10,883 bases
Orientation:
Minus strand

Genomic View for HAS1 Gene

Genes around HAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAS1 Gene

Proteins for HAS1 Gene

  • Protein details for HAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92839-HYAS1_HUMAN
    Recommended name:
    Hyaluronan synthase 1
    Protein Accession:
    Q92839
    Secondary Accessions:
    • Q14470
    • Q9NS49

    Protein attributes for HAS1 Gene

    Size:
    578 amino acids
    Molecular mass:
    64832 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12351.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HAS1 Gene

Post-translational modifications for HAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAS1 Gene

No data available for DME Specific Peptides for HAS1 Gene

Domains & Families for HAS1 Gene

Gene Families for HAS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for HAS1 Gene

Suggested Antigen Peptide Sequences for HAS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92839

UniProtKB/Swiss-Prot:

HYAS1_HUMAN :
  • Belongs to the NodC/HAS family.
Family:
  • Belongs to the NodC/HAS family.
genes like me logo Genes that share domains with HAS1: view

Function for HAS1 Gene

Molecular function for HAS1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).
GENATLAS Biochemistry:
hyaluronan synthase gene 1

Enzyme Numbers (IUBMB) for HAS1 Gene

Phenotypes From GWAS Catalog for HAS1 Gene

Gene Ontology (GO) - Molecular Function for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0050501 hyaluronan synthase activity IEA,TAS --
genes like me logo Genes that share ontologies with HAS1: view
genes like me logo Genes that share phenotypes with HAS1: view

Animal Models for HAS1 Gene

MGI Knock Outs for HAS1:
  • Has1 Has1<tm1Nita>

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HAS1 Gene

Localization for HAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAS1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAS1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9169154
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HAS1: view

Pathways & Interactions for HAS1 Gene

genes like me logo Genes that share pathways with HAS1: view

UniProtKB/Swiss-Prot Q92839-HYAS1_HUMAN

  • Pathway: Glycan biosynthesis; hyaluronan biosynthesis.

Gene Ontology (GO) - Biological Process for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS 8798544
GO:0007155 cell adhesion TAS 8798544
GO:0010764 negative regulation of fibroblast migration IMP 19577615
GO:0030213 hyaluronan biosynthetic process IEA,TAS --
GO:0036120 cellular response to platelet-derived growth factor stimulus IDA 17324121
genes like me logo Genes that share ontologies with HAS1: view

No data available for SIGNOR curated interactions for HAS1 Gene

Drugs & Compounds for HAS1 Gene

(5) Drugs for HAS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 535
Magnesium Approved Nutra 0
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine 5'-diphosphate Experimental Pharma 0

(2) Additional Compounds for HAS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • (2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-Dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
  • UDP-GlcNAc
  • UDP-N-Acetyl-D-glucosamine
  • UDP-N-Acetylglucosamine
  • URIDINE-diphosphATE-N-acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with HAS1: view

Transcripts for HAS1 Gene

mRNA/cDNA for HAS1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAS1 Gene

Hyaluronan synthase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAS1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for HAS1 Gene

GeneLoc Exon Structure for
HAS1
ECgene alternative splicing isoforms for
HAS1

Expression for HAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAS1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x13.7), Ovary (x5.8), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for HAS1 Gene

This gene is overexpressed in Breast (43.7) and Placenta (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HAS1 Gene



Protein tissue co-expression partners for HAS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HAS1 Gene:

HAS1

SOURCE GeneReport for Unigene cluster for HAS1 Gene:

Hs.57697

mRNA Expression by UniProt/SwissProt for HAS1 Gene:

Q92839-HYAS1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.

Evidence on tissue expression from TISSUES for HAS1 Gene

  • Nervous system(4.3)
  • Lymph node(4)
  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HAS1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HAS1 Gene

Orthologs for HAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAS1 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAS1 34 33
  • 87.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Has1 33
  • 84.61 (n)
mouse
(Mus musculus)
Mammalia Has1 16 34 33
  • 84.43 (n)
oppossum
(Monodelphis domestica)
Mammalia HAS1 34
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAS1 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAS1 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAS1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491673 33
  • 61.78 (n)
zebrafish
(Danio rerio)
Actinopterygii has1 34 33
  • 61.94 (n)
OneToOne
Species where no ortholog for HAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAS1 Gene

ENSEMBL:
Gene Tree for HAS1 (if available)
TreeFam:
Gene Tree for HAS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HAS1: view image

Paralogs for HAS1 Gene

Paralogs for HAS1 Gene

(2) SIMAP similar genes for HAS1 Gene using alignment to 7 proteins:

  • HYAS1_HUMAN
  • D2N2G5_HUMAN
  • G3V1S7_HUMAN
  • M0QXH4_HUMAN
  • M0R1L3_HUMAN
  • M0R2V0_HUMAN
  • Q8IYH3_HUMAN
genes like me logo Genes that share paralogs with HAS1: view

Variants for HAS1 Gene

Sequence variations from dbSNP and Humsavar for HAS1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000217056 -- 51,723,502(-) A/G intron_variant
rs1000470620 -- 51,722,936(-) G/A intron_variant
rs1000759585 -- 51,723,188(-) G/A intron_variant
rs1000795865 -- 51,718,990(-) T/C intron_variant
rs1001220062 -- 51,724,625(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HAS1 Gene

Variant ID Type Subtype PubMed ID
dgv3625n100 CNV gain 25217958
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781
nsv9742 CNV gain+loss 18304495

Variation tolerance for HAS1 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.73; 91.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAS1 Gene

Human Gene Mutation Database (HGMD)
HAS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAS1 Gene

Disorders for HAS1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for HAS1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
waldenstrom macroglobulinemia
  • lymphoplasmacytic lymphoma
foodborne botulism
  • wound botulism
swine influenza
  • influenza due to influenza a virus subtype h1n1
byssinosis
  • cotton mill fever
extratemporal epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search HAS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HAS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAS1 Gene

Publications for HAS1 Gene

  1. Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (PMID: 15794859) Adamia S … Pilarski LM (Clinical lymphoma 2005) 3 22 44 58
  2. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PMID: 9169154) Spicer AP … McDonald JA (Genomics 1997) 2 3 22 58
  3. Functional cloning of the cDNA for a human hyaluronan synthase. (PMID: 8798544) Shyjan AM … Briskin MJ (The Journal of biological chemistry 1996) 3 4 22 58
  4. Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes. (PMID: 19148550) Albrecht C … Marlovits S (International journal of molecular medicine 2009) 3 22 58
  5. Genetic abnormalities in Waldenström's macroglobulinemia. (PMID: 19362966) Adamia S … Pilarski LM (Clinical lymphoma & myeloma 2009) 3 22 58

Products for HAS1 Gene

Sources for HAS1 Gene

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