Aliases for HARBI1 Gene

Aliases for HARBI1 Gene

  • Harbinger Transposase Derived 1 2 3 5
  • Harbinger Transposase-Derived Nuclease 3 4
  • Putative Nuclease HARBI1 3 4
  • C11orf77 3 4
  • Chromosome 11 Open Reading Frame 77 2
  • EC 3.1.-.- 4
  • FLJ32675 2
  • HARBI1 5

External Ids for HARBI1 Gene

Previous HGNC Symbols for HARBI1 Gene

  • C11orf77

Previous GeneCards Identifiers for HARBI1 Gene

  • GC11M046583
  • GC11M046331
  • GC11M046672
  • GC11M048067
  • GC11M048792
  • GC11M049891
  • GC11M047079
  • GC11M047924
  • GC11M055793
  • GC11M056002
  • GC11M056153
  • GC11M059675
  • GC11M050780
  • GC11M051575
  • GC11M052237
  • GC11M052897
  • GC11M053565
  • GC11M054231
  • GC11M054897
  • GC11M055595

Summaries for HARBI1 Gene

GeneCards Summary for HARBI1 Gene

HARBI1 (Harbinger Transposase Derived 1) is a Protein Coding gene. Diseases associated with HARBI1 include Hereditary Breast Ovarian Cancer Syndrome. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and nuclease activity.

UniProtKB/Swiss-Prot Summary for HARBI1 Gene

  • Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Additional gene information for HARBI1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HARBI1 Gene

Genomics for HARBI1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HARBI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HARBI1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HARBI1

Top Transcription factor binding sites by QIAGEN in the HARBI1 gene promoter:
  • CUTL1
  • Egr-1
  • GATA-2
  • HFH-1
  • LyF-1
  • MIF-1
  • NF-1
  • NF-1/L
  • Pax-4a
  • YY1

Genomic Locations for HARBI1 Gene

Genomic Locations for HARBI1 Gene
chr11:46,602,861-46,617,909
(GRCh38/hg38)
Size:
15,049 bases
Orientation:
Minus strand
chr11:46,624,411-46,639,459
(GRCh37/hg19)
Size:
15,049 bases
Orientation:
Minus strand

Genomic View for HARBI1 Gene

Genes around HARBI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HARBI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HARBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARBI1 Gene

Proteins for HARBI1 Gene

  • Protein details for HARBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MB7-HARB1_HUMAN
    Recommended name:
    Putative nuclease HARBI1
    Protein Accession:
    Q96MB7
    Secondary Accessions:
    • D3DQP9

    Protein attributes for HARBI1 Gene

    Size:
    349 amino acids
    Molecular mass:
    39146 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with NAIF1.

neXtProt entry for HARBI1 Gene

Post-translational modifications for HARBI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HARBI1 Gene

Domains & Families for HARBI1 Gene

Gene Families for HARBI1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HARBI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HARBI1 Gene

GenScript: Design optimal peptide antigens:
  • Harbinger transposase-derived nuclease (HARB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96MB7

UniProtKB/Swiss-Prot:

HARB1_HUMAN :
  • Belongs to the HARBI1 family.
Family:
  • Belongs to the HARBI1 family.
genes like me logo Genes that share domains with HARBI1: view

Function for HARBI1 Gene

Molecular function for HARBI1 Gene

UniProtKB/Swiss-Prot Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Enzyme Numbers (IUBMB) for HARBI1 Gene

Phenotypes From GWAS Catalog for HARBI1 Gene

Gene Ontology (GO) - Molecular Function for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HARBI1: view
genes like me logo Genes that share phenotypes with HARBI1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HARBI1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HARBI1 Gene

Localization for HARBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARBI1 Gene

Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HARBI1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0034451 centriolar satellite IDA --
genes like me logo Genes that share ontologies with HARBI1: view

Pathways & Interactions for HARBI1 Gene

PathCards logo

SuperPathways for HARBI1 Gene

No Data Available

Interacting Proteins for HARBI1 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000317743 Q96MB7-HARB1_HUMAN for HARBI1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Pathways by source and SIGNOR curated interactions for HARBI1 Gene

Drugs & Compounds for HARBI1 Gene

No Compound Related Data Available

Transcripts for HARBI1 Gene

mRNA/cDNA for HARBI1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HARBI1

Alternative Splicing Database (ASD) splice patterns (SP) for HARBI1 Gene

No ASD Table

Relevant External Links for HARBI1 Gene

GeneLoc Exon Structure for
HARBI1

Expression for HARBI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HARBI1 Gene

mRNA differential expression in normal tissues according to GTEx for HARBI1 Gene

This gene is overexpressed in Testis (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HARBI1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HARBI1

SOURCE GeneReport for Unigene cluster for HARBI1 Gene:

Hs.714463

mRNA Expression by UniProt/SwissProt for HARBI1 Gene:

Q96MB7-HARB1_HUMAN
Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung.

Evidence on tissue expression from TISSUES for HARBI1 Gene

  • Pancreas(4.6)
  • Intestine(3)
  • Nervous system(2.9)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with HARBI1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HARBI1 Gene

Orthologs for HARBI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HARBI1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HARBI1 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HARBI1 30 31
  • 93.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HARBI1 30 31
  • 91.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HARBI1 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Harbi1 30
  • 88.25 (n)
Mouse
(Mus musculus)
Mammalia Harbi1 30 17 31
  • 87.39 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HARBI1 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HARBI1 30 31
  • 76.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HARBI1 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493758 30
  • 68.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26314 30
Zebrafish
(Danio rerio)
Actinopterygii harbi1 30 31
  • 63.79 (n)
OneToOne
Dr.15651 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG43088 31
  • 16 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G55350 30
  • 41.51 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0838900 30
  • 43.04 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for HARBI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HARBI1 Gene

ENSEMBL:
Gene Tree for HARBI1 (if available)
TreeFam:
Gene Tree for HARBI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HARBI1: view image

Paralogs for HARBI1 Gene

No data available for Paralogs for HARBI1 Gene

Variants for HARBI1 Gene

Additional dbSNP identifiers (rs#s) for HARBI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HARBI1 Gene

Variant ID Type Subtype PubMed ID
esv3387485 CNV insertion 20981092
esv993220 OTHER inversion 20482838

Variation tolerance for HARBI1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HARBI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HARBI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HARBI1 Gene

Disorders for HARBI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HARBI1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with HARBI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HARBI1 Gene

Publications for HARBI1 Gene

  1. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L … Ivics Z (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4
  2. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov VV … Jurka J (DNA and cell biology 2004) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for HARBI1 Gene

Sources for HARBI1 Gene