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Aliases for HAO2 Gene

Aliases for HAO2 Gene

  • Hydroxyacid Oxidase 2 2 3 3 5
  • Long-Chain L-2-Hydroxy Acid Oxidase 2 3 4
  • (S)-2-Hydroxy-Acid Oxidase, Peroxisomal 3 4
  • Cell Growth-Inhibiting Gene 16 Protein 3 4
  • Long Chain Alpha-Hydroxy Acid Oxidase 3 4
  • Hydroxyacid Oxidase 2 (Long Chain) 2 3
  • Glycolate Oxidase 2 3
  • HAOX2 3 4
  • Growth-Inhibiting Protein 16 2
  • (S)-2-Hydroxy-Acid Oxidase 2
  • EC 4
  • GIG16 3

External Ids for HAO2 Gene

Previous GeneCards Identifiers for HAO2 Gene

  • GC01P120358
  • GC01P118749
  • GC01P119058
  • GC01P119257
  • GC01P119623
  • GC01P119712
  • GC01P119913
  • GC01P117769

Summaries for HAO2 Gene

Entrez Gene Summary for HAO2 Gene

  • This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HAO2 Gene

HAO2 (Hydroxyacid Oxidase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and FMN binding. An important paralog of this gene is HAO1.

UniProtKB/Swiss-Prot for HAO2 Gene

  • Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Additional gene information for HAO2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAO2 Gene

Genomics for HAO2 Gene

GeneHancer (GH) Regulatory Elements for HAO2 Gene

Promoters and enhancers for HAO2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J119368 Promoter 0.9 EPDnew 650.7 +0.0 14 0.1 RXRA MAFG RAD21 YY1 SP1 JUND MAFF ZNF316 HNF4G HNF4A HAO2 HAO2-IT1 GC01P118983
GH01J119380 Promoter 0.9 EPDnew 650.4 +11.8 11758 0.1 FOXA2 TAF1 RXRA MAX REST RAD21 FOXA1 YY1 SP1 JUND HAO2 HAO2-IT1 HSD3B2 GC01P118983
GH01J119327 Promoter/Enhancer 1.4 Ensembl ENCODE 10.9 -41.4 -41434 1.6 PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF213 LINC01780 ENSG00000227712 LOC101929147 HAO2 HAO2-IT1 GC01P118983
GH01J119339 Enhancer 0.9 ENCODE 11.2 -27.6 -27593 2.8 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 NFKBIZ RXRA HAO2-IT1 HAO2 PIR50994 PIR56417 LINC01780 GC01P118983
GH01J119278 Enhancer 0.7 ENCODE 11.7 -88.9 -88885 1.9 JUN MAX RFX5 TEAD3 HIC1 ZNF335 CTBP1 POLR2A FOSL2 FOS HAO2-IT1 HAO2 RNU1-75P WARS2 GC01P119270 ENSG00000227712 GC01P118983
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HAO2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • SRF (504 AA)
  • SRF
  • C/EBPalpha
  • AML1a
  • C/EBPbeta
  • ARP-1

Genomic Locations for HAO2 Gene

Genomic Locations for HAO2 Gene
25,355 bases
Plus strand
25,352 bases
Plus strand

Genomic View for HAO2 Gene

Genes around HAO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAO2 Gene

Proteins for HAO2 Gene

  • Protein details for HAO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hydroxyacid oxidase 2
    Protein Accession:
    Secondary Accessions:
    • Q2TU86
    • Q5QP00
    • Q9UJS6

    Protein attributes for HAO2 Gene

    351 amino acids
    Molecular mass:
    38839 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Homotetramer or homooctamer.

    Alternative splice isoforms for HAO2 Gene


neXtProt entry for HAO2 Gene

Post-translational modifications for HAO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HAO2 Gene

Domains & Families for HAO2 Gene

Gene Families for HAO2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HAO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
genes like me logo Genes that share domains with HAO2: view

Function for HAO2 Gene

Molecular function for HAO2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).

Enzyme Numbers (IUBMB) for HAO2 Gene

Phenotypes From GWAS Catalog for HAO2 Gene

Gene Ontology (GO) - Molecular Function for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003973 (S)-2-hydroxy-acid oxidase activity IDA,IEA 10777549
GO:0005102 signaling receptor binding IPI 20178365
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity IEA --
genes like me logo Genes that share ontologies with HAO2: view
genes like me logo Genes that share phenotypes with HAO2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAO2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAO2 Gene

Localization for HAO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAO2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAO2 gene
Compartment Confidence
extracellular 5
peroxisome 5
cytoskeleton 2
mitochondrion 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA,IDA 10777549
GO:0005782 peroxisomal matrix TAS --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with HAO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HAO2 Gene

Pathways & Interactions for HAO2 Gene

genes like me logo Genes that share pathways with HAO2: view

Gene Ontology (GO) - Biological Process for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process TAS --
GO:0019395 fatty acid oxidation IDA 10777549
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HAO2: view

No data available for SIGNOR curated interactions for HAO2 Gene

Drugs & Compounds for HAO2 Gene

(5) Drugs for HAO2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flavin Mononucleotide Approved, Investigational Pharma Target 8
Glycolic acid Approved, Investigational Pharma 19
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxygen Approved, Vet_approved Pharma 0
Glyoxylic acid Experimental Pharma 0
genes like me logo Genes that share compounds with HAO2: view

Transcripts for HAO2 Gene

Unigene Clusters for HAO2 Gene

Hydroxyacid oxidase 2 (long chain):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HAO2

Alternative Splicing Database (ASD) splice patterns (SP) for HAO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP2: -
SP3: - -
SP4: - -

Relevant External Links for HAO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAO2 Gene

mRNA differential expression in normal tissues according to GTEx for HAO2 Gene

This gene is overexpressed in Liver (x37.8) and Kidney - Cortex (x13.1).

Protein differential expression in normal tissues from HIPED for HAO2 Gene

This gene is overexpressed in Lung (28.0), Kidney (24.9), and Liver (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HAO2 Gene

Protein tissue co-expression partners for HAO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAO2 Gene:


SOURCE GeneReport for Unigene cluster for HAO2 Gene:


mRNA Expression by UniProt/SwissProt for HAO2 Gene:

Tissue specificity: Liver and kidney.

Evidence on tissue expression from TISSUES for HAO2 Gene

  • Liver(4.7)
  • Kidney(4.6)
genes like me logo Genes that share expression patterns with HAO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAO2 Gene

Orthologs for HAO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HAO2 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia HAO2 34 33
  • 85.75 (n)
(Bos Taurus)
Mammalia HAO2 34 33
  • 82.72 (n)
(Rattus norvegicus)
Mammalia Hao2 33
  • 79.87 (n)
(Mus musculus)
Mammalia Hao2 16 34 33
  • 78.63 (n)
(Ornithorhynchus anatinus)
Mammalia HAO2 34
  • 47 (a)
(Gallus gallus)
Aves HAO2 34 33
  • 63.72 (n)
(Anolis carolinensis)
Reptilia HAO2 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hao2 33
  • 63.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398510 33
(Danio rerio)
Actinopterygii hao2 34 33
  • 63.31 (n)
zgc63690 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.904 33
fruit fly
(Drosophila melanogaster)
Insecta CG18003 34 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea F41E6.5 34 35
  • 39 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02640g 33
  • 50.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB2 34 33
  • 48.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G14150 33
  • 51.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2092 33
(Oryza sativa)
Liliopsida Os07g0616500 33
  • 51.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7836 34
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08272 33
  • 49.85 (n)
Species where no ortholog for HAO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAO2 Gene

Gene Tree for HAO2 (if available)
Gene Tree for HAO2 (if available)
Evolutionary constrained regions (ECRs) for HAO2: view image

Paralogs for HAO2 Gene

Paralogs for HAO2 Gene

(1) SIMAP similar genes for HAO2 Gene using alignment to 3 proteins:

  • Q5QP00_HUMAN
  • Q5QP02_HUMAN
genes like me logo Genes that share paralogs with HAO2: view

Variants for HAO2 Gene

Sequence variations from dbSNP and Humsavar for HAO2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000039917 -- 119,376,954(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000098938 -- 119,374,373(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000172988 -- 119,373,029(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000244644 -- 119,382,715(+) T/C intron_variant
rs1000249025 -- 119,390,649(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HAO2 Gene

Variant ID Type Subtype PubMed ID
esv1759268 CNV insertion 17803354
esv2761649 CNV gain 21179565
esv2763647 CNV gain+loss 21179565
esv34089 CNV loss 18971310
nsv1004662 CNV gain 25217958
nsv2599 CNV deletion 18451855
nsv524681 CNV gain 19592680

Variation tolerance for HAO2 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAO2 Gene

Disorders for HAO2 Gene

Additional Disease Information for HAO2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HAO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAO2 Gene

Publications for HAO2 Gene

  1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PMID: 10777549) Jones JM … Gould SJ (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for HAO2 Gene

Sources for HAO2 Gene

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